Sophie Caroline Williams
Pfizer
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Publication
Featured researches published by Sophie Caroline Williams.
Bioorganic & Medicinal Chemistry Letters | 2010
David C. Blakemore; Justin Stephen Bryans; Pauline Carnell; Christopher L. Carr; Nicola E.A. Chessum; Mark John Field; Natasha Kinsella; Simon A. Osborne; Andrew N. Warren; Sophie Caroline Williams
Synthesis of a number of bicyclic five-membered ring derivatives of gabapentin led to the identification of two compounds, (-)-(11A) and (20A) which both had an excellent level of potency against alpha(2)delta and were profiled in an in vivo model of neuropathic pain.
Bioorganic & Medicinal Chemistry Letters | 2010
David C. Blakemore; Justin Stephen Bryans; Pauline Carnell; Mark John Field; Natasha Kinsella; Jack K. Kinsora; Leonard T. Meltzer; Simon A. Osborne; Lisa R. Thompson; Sophie Caroline Williams
A range of 3,4-alkylated five-membered ring derivatives of gabapentin were synthesised. One compound (21) had an excellent level of potency against alpha(2)delta and was profiled in in vivo models of pain and anxiety.
Bioorganic & Medicinal Chemistry Letters | 2010
David C. Blakemore; Justin Stephen Bryans; Pauline Carnell; Nicola E.A. Chessum; Mark John Field; Natasha Kinsella; Jack K. Kinsora; Simon A. Osborne; Sophie Caroline Williams
A range of 3-alkylated five-membered ring derivatives of Gabapentin were synthesized and several were found to have good levels of potency against the alpha2delta calcium subunit of a voltage-gated calcium channel. Two compounds were profiled in in vivo models of pain and anxiety.
Archive | 2002
David C. Blakemore; Justin Stephen Bryans; Sophie Caroline Williams
Archive | 2001
David C. Blakemore; Justin Stephen Bryans; Sophie Caroline Williams
Bioorganic & Medicinal Chemistry Letters | 2005
George M. Buckley; Natasha Davies; Hazel Joan Dyke; Philip J. Gilbert; Duncan Hannah; Alan Findlay Haughan; Caroline A. Hunt; William R. Pitt; Rachael Profit; Nicholas C. Ray; Marianna Dilani Richard; Andrew Sharpe; Alicia J. Taylor; Justine M. Whitworth; Sophie Caroline Williams
Bioorganic & Medicinal Chemistry Letters | 2008
Robert John Watson; Daniel Rees Allen; Helen L. Birch; Gayle A. Chapman; Frances Celia Anne Galvin; Louise A. Jopling; Roland L. Knight; Dorica Meier; Kathryn Oliver; Johannes W.G. Meissner; David Alan Owen; Elizabeth J. Thomas; Neil Tremayne; Sophie Caroline Williams
Bioorganic & Medicinal Chemistry Letters | 2008
Roland L. Knight; Daniel Rees Allen; Helen L. Birch; Gayle A. Chapman; Frances Celia Anne Galvin; Louise A. Jopling; Christopher James Lock; Johannes W.G. Meissner; David Alan Owen; Gilles Raphy; Robert John Watson; Sophie Caroline Williams
Bioorganic & Medicinal Chemistry Letters | 2005
Helen L. Birch; George M. Buckley; Natasha Davies; Hazel Joan Dyke; Elizabeth J. Frost; Philip J. Gilbert; Duncan Hannah; Alan Findlay Haughan; Michael J. Madigan; Trevor Morgan; William R. Pitt; Andrew J. Ratcliffe; Nicholas C. Ray; Marianna Dilani Richard; Andrew Sharpe; Alicia J. Taylor; Justine M. Whitworth; Sophie Caroline Williams
Bioorganic & Medicinal Chemistry Letters | 2006
Rebekah Beevers; George M. Buckley; Natasha Davies; Joanne L. Fraser; Francis C. Galvin; Duncan Hannah; Alan Findlay Haughan; Kerry Jenkins; Stephen R. Mack; William R. Pitt; Andrew J. Ratcliffe; Marianna Dilani Richard; Verity Margaret Sabin; Andrew Sharpe; Sophie Caroline Williams
