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Dive into the research topics where Soraya de Mattos Camargo Grossmann is active.

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Featured researches published by Soraya de Mattos Camargo Grossmann.


Journal of Public Health Dentistry | 2009

Oral Mucosal Conditions in Chronic Hepatitis C Brazilian Patients: A Cross‐Sectional Study

Soraya de Mattos Camargo Grossmann; Rosângela Teixeira; Maria Cássia Ferreira de Aguiar; Mariela Dutra Gontijo Moura; Maria Auxiliadora Vieira do Carmo

OBJECTIVE Our purpose was to carry out an epidemiological study to assess the prevalence of oral mucosal conditions in Brazilian patients with chronic hepatitis C. METHODS A cross-sectional survey was carried out on 215 patients with chronic hepatitis C who were examined for oral mucosal conditions, including oral mucosal lesions and variations of normality. RESULTS The prevalence of patients with chronic hepatitis C presenting oral mucosal conditions was 96.3 percent (207 patients). Oral mucosal lesions were present in 147 patients (68.4 percent), whereas variations of normality were observed in 173 patients (80.5 percent). The most common lesions included cheek biting in 42 cases (19.5 percent), candidiasis in 39 cases (18.1 percent), and leukoplakia in 28 cases (13.0 percent). The association of oral lichen planus with hepatitis C virus (HCV) infection proved to be statistically significant (P = 0.002). The most frequent variations of normality included Fordyces spots in 96 cases (44.7 percent), lingual varicosities in 67 cases (31.2 percent), and fissured tongue in 60 cases (27.9 percent). CONCLUSION The prevalence of patients with chronic hepatitis C presenting oral mucosal conditions was 96.3 percent. Despite this high prevalence, only the association between oral lichen planus and hepatitis C showed statistical significance. Considering that HCV infection may be associated with extrahepatic disorders, such as oral manifestations, efforts should be made to clarify the possible relation between oral conditions and HCV infection. This may be helpful in the earlier diagnosis of the infection mainly in asymptomatic patients.


American Journal of Clinical Pathology | 2007

Oral lichen planus and chronic hepatitis C: a controversial association.

Soraya de Mattos Camargo Grossmann; Maria Cássia Ferreira de Aguiar; Rosângela Teixeira; Maria Auxiliadora Vieira do Carmo

Our aim was to study the possible association between oral lichen planus and chronic hepatitis C in patients from the state of Minas Gerais, Brazil. Two groups of patients were studied: group 1, 50 patients with oral lichen planus evaluated for the presence of chronic hepatitis C; and group 2, 215 patients with chronic hepatitis C examined for evidence of oral lichen planus. Diagnosis of oral lichen planus in both groups was based on clinical and histologic findings. One case of chronic hepatitis C was diagnosed in group 1 (2.0%), which was not considered statistically significant (P = .464). In group 2, the prevalence of oral lichen planus was 2.3% (5 cases), which showed statistical significance (P = .002). Although our results suggest oral lichen planus as an extrahepatic manifestation of chronic hepatitis C in the studied population, the association between these two entities should be further investigated.


European Journal of Gastroenterology & Hepatology | 2008

Exacerbation of oral lichen planus lesions during treatment of chronic hepatitis C with pegylated interferon and ribavirin

Soraya de Mattos Camargo Grossmann; Rosângela Teixeira; Maria Cássia Ferreira de Aguiar; Maria Auxiliadora Vieira do Carmo

It is estimated that 170-200 million people in the world are chronically infected with the hepatitis C virus. This fact indicates that the prevention and treatment of hepatitis C virus infection are a priority in public health care. To date, the best treatment consists of the combination of pegylated interferon (IFN) and ribavirin. IFN is costly and associated with low tolerance and severe side effects. Ribavirin is also problematic because it causes secondary anemia in most patients. It has been described that oral lichen planus (OLP) can appear or be exacerbated during the treatment of chronic hepatitis C. The improvement of the lesions of OLP after the discontinuation of therapy suggests that IFN may induce or worsen these lesions in some patients. This study examines three cases of exacerbation of OLP during the treatment of chronic hepatitis C with pegylated IFN and ribavirin.


Journal of Clinical Pathology | 2010

Xerostomia, hyposalivation and sialadenitis in patients with chronic hepatitis C are not associated with the detection of HCV RNA in saliva or salivary glands

Soraya de Mattos Camargo Grossmann; Rosângela Teixeira; Guilherme Oliveira; Frederico Omar Gleber-Netto; Flávio Marcos Gomes Araújo; Filipe Maia Araújo; Maria Auxiliadora Vieira do Carmo

Objective Salivary gland disorders in patients with chronic hepatitis C (CHC) have been considered oral extrahepatic manifestations, reinforcing the hepatitis C virus (HCV) as a sialotropic virus. Hence, the authors investigated the prevalence of HCV RNA in saliva and salivary glands and its possible association with xerostomia, hyposalivation and sialadenitis in patients with CHC. Patients and methods In 65 patients with confirmed CHC, the HCV RNA was investigated by nested RT-PCR in saliva samples and minor salivary glands. Xerostomia, hyposalivation, clinical and histopathological evidence of sialadenitis were also evaluated. Univariate and multivariate analyses were employed to verify associations. Results HCV RNA was detected in the saliva of 26/65 (40.0%) patients and in 12/65 (18.5%) salivary glands. Xerostomia was reported by 23/65 (35.4%) patients, and hyposalivation was diagnosed in 13/65 (20.0%) patients. Sialadenitis was confirmed by histopathological features in 31/65 (47.7%) patients. Twelve (38.7%) of the 31 patients with sialadenitis presented HCV RNA in saliva and 2/31 (6.5%) in salivary glands. No associations were found between xerostomia, hyposalivation or sialadenitis and the detection of HCV RNA in saliva or in salivary glands. Conclusions Although xerostomia, hyposalivation and sialadenitis are frequent findings in CHC patients, our study did not confirm the association between the detection of HCV RNA in saliva or salivary glands with these salivary gland disorders. However, an indirect role of HCV by immune-mediated virus mechanisms in the pathogenesis of salivary gland disorders in this group of patients cannot be ruled out.


Journal of Oral Pathology & Medicine | 2013

Correlation between salivary anti‐HCV antibodies and HCV RNA in saliva and salivary glands of patients with chronic hepatitis C

Patrícia Carlos Caldeira; Karla Rachel Oliveira e Silva; Tarcília Aparecida Silva; Soraya de Mattos Camargo Grossmann; Rosângela Teixeira; Maria Auxiliadora Vieira do Carmo

BACKGROUND To investigate the correlation between anti-hepatitis C virus (HCV) antibodies in saliva and detection of HCV RNA in saliva and salivary glands of patients with chronic hepatitis C. METHODS A total of 180 samples of saliva (131 non-stimulated and 49 stimulated) from 133 patients with chronic hepatitis C were tested by ELISA for presence of anti-HCV antibodies. Results were compared with the detection of HCV RNA in saliva and salivary glands samples. Pearsons chi-squared and Fishers exact tests were performed for statistical analysis. RESULTS Anti-HCV antibodies could be detected in 47/180 (26.1%) saliva samples. In 11/47 (23.5%) of these, HCV RNA was also detected. From the 133/180 (73.9%) saliva samples with undetectable anti-HCV antibodies, 49/133 (36.8%) were positive for HCV RNA at least in one saliva sample. From the 64 patients from whom salivary gland samples were available, 17/64 (26.6%) had detectable anti-HCV antibodies in saliva, from which 2/17 (11.8%) also had HCV RNA in the salivary gland. From the 47/64 (73.4%) cases negative for anti-HCV antibodies in saliva, 10/47 (21.3%) were positive for HCV RNA in salivary gland. CONCLUSIONS Taken together, our results suggest that there is no correlation between the presence of anti-HCV antibodies in saliva and the detection of HCV RNA in saliva and salivary glands in patients with chronic hepatitis C. Nevertheless, as there was a statistically significant difference between detection of anti-HCV antibodies and HCV RNA in stimulated saliva, our study points toward the need for new research on mechanisms of HCV shedding in saliva.


Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2009

Anterior midline nodule of the hard palate.

Soraya de Mattos Camargo Grossmann; Alpine Cristina Rodrigues Johann; Wagner Henriques Castro; Horácio Friedman; Ricardo Santiago Gomez; Ricardo Alves Mesquita

Anterior midline nodule of the hard palate Soraya de Mattos Camargo Grossmann, DDS, MS, Aline Cristina Rodrigues Johann, DDS, MS, Wagner Henriques Castro, DDS, PhD, Horacio Friedman, MD, Ricardo Santiago Gomez, DDS, PhD, and Ricardo Alves Mesquita, DDS, MS, Belo Horizonte and Brasilia, Brazil UNIVERSIDADE FEDERAL DE MINAS GERAIS AND DIAGNOSE PATHOLOGY LABORATORY (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108:808-811)


Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology | 2010

Detection of HCV RNA in saliva does not correlate with salivary flow or xerostomia in patients with chronic hepatitis C

Soraya de Mattos Camargo Grossmann; Rosângela Teixeira; Guilherme Oliveira; Maria Auxiliadora Vieira do Carmo

OBJECTIVE The objective of this study was to investigate the prevalence of hepatitis C virus (HCV) RNA in saliva and its possible association with xerostomia and hyposalivation in patients with chronic hepatitis C. STUDY DESIGN One hundred and thirty-six patients with confirmed diagnosis of chronic hepatitis C were prospectively analyzed before HCV treatment. The prevalence of xerostomia and hyposalivation was clinically evaluated. HCV RNA was investigated in saliva samples by qualitative PCR test. Univariate and multivariate analyses were used to verify associations. RESULTS Xerostomia was reported by 48 (35.3%) patients, whereas hyposalivation was observed in 26 (19.1%). HCV RNA was positive in the saliva of 53 (39.0%) patients. An association among HCV RNA-positive saliva with xerostomia or hyposalivation was not observed. CONCLUSION Our results demonstrate that the detection of HCV in saliva does not correlate with salivary flow or xerostomia in patients with chronic hepatitis C.


Head and Neck Pathology | 2011

Desmoplastic fibroblastoma (collagenous fibroma): a case identified in the buccal mucosa.

Sílvia Ferreira de Sousa; Patrícia Carlos Caldeira; Soraya de Mattos Camargo Grossmann; Maria Cássia Ferreira de Aguiar; Ricardo Alves Mesquita

Desmoplastic fibroblastoma is a rare, benign, soft tissue tumor affecting mainly the subcutaneous and muscle tissue. Only five cases identified in the oral cavity have been reported in prior literature. This article presents a case report of a 56-year-old man, with no previous history of trauma, who presented a slow-growing mass in the buccal mucosa. Histopathology and immunohistochemistry staining studies were performed, and a diagnosis of the desmoplastic fibroblastoma was made. The patient has been disease-free for one year.


Human Immunology | 2014

Inflammatory cells in minor salivary glands of patients with chronic hepatitis C: Immunophenotype, pattern of distribution, and comparison with liver samples

Patrícia Carlos Caldeira; Karla Rachel Oliveira e Silva; Paula Vieira Teixeira Vidigal; Soraya de Mattos Camargo Grossmann; Maria Auxiliadora Vieira do Carmo

OBJECTIVES To characterize the immunophenotype and the distribution of the inflammatory infiltrate (INF) in salivary glands (SG) of patients with chronic hepatitis C, comparing with laboratorial data (genotype, viral load, METAVIR, and HCV RNA in SG), and liver. METHODS INF was classified as diffuse or focal. Immunohistochemistry for CD3, CD20, CD8, CD4, CD57, CD68, and S100 was performed in 61 SG and 59 livers. RESULTS Diffuse INF was more common in SG than in liver. CD3(+), CD20(+), and CD8(+) were the most frequent cells in both tissues, with few CD57(+), CD68(+), and S100(+) cells. CD4(+) cells were common in liver, but rare in SG. Liver presented higher indexes for all markers, except S100(+) (p<0.05). Higher CD3(+), CD20(+), and CD8(+) (p<0.05) were observed in SG with focal infiltrate than with diffuse infiltrate. In liver, CD20(+) and CD3(+) were higher in focal infiltrate, and CD68(+) in diffuse infiltrate (p<0.05). Comparisons with laboratorial data did not show statistical significance. CONCLUSIONS The INF in SG was mainly composed by T and B lymphocytes, mostly cytotoxic T cells. The glandular INF can present differences in composition according to its distribution. A more intense inflammation was observed in liver, but similar cell types were identified in SG, except for CD4(+).


Revista da Universidade Vale do Rio Verde | 2018

REABILITAÇÃO PROTÉTICA ORAL EM PACIENTE ONCOLÓGICO

Daniel Pereira Rabelo; Renan Paganini Tanure; Flávia Moysés Costa de Grajeda; Soraya de Mattos Camargo Grossmann

O carcinoma adenoide cistico representa um tumor maligno que ocorre na regiao da cabeca e pescoco, vindo a atingir regioes submandibulares e salivares. Em decorrencia das diversas intervencoes cirurgicas para retirada das mencionadas neoplasias, o paciente, muitas vezes, apresentara uma ruptura da area atingida, prejudicando a funcao mastigatoria, a fonetica, a degluticao, estetica e o proprio estado emocional do individuo. Dessa forma, por intermedio da protese obturadora, busca-se conceder maior conforto e bem-estar ao paciente, devolvendo ao mesmo a capacidade de se comunicar e de se alimentar normalmente. Relato do caso: este relato clinico descreve a reabilitacao protetica de um paciente que fora submetido a maxilectomia parcial unilateral para tratamento de carcinoma adenoide cistico, sendo necessario um procedimento pouco convencional para fins de estabilizacao da protese. Consideracoes finais: observa-se que a protese obturadora visa sanar ou amenizar as diversas consequencias oriundas das intervencoes cirurgicas para retirada do carcinoma adenoide cistico.

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Ricardo Alves Mesquita

Universidade Federal de Minas Gerais

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Rosângela Teixeira

Universidade Federal de Minas Gerais

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Ana Maria Rebouças Rodrigues

Universidade Federal de Minas Gerais

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Mariela Dutra Gontijo Moura

Universidade Federal de Minas Gerais

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Maria Cássia Ferreira de Aguiar

Universidade Federal de Minas Gerais

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Camilo Aquino Melgaço

Universidade Federal de Minas Gerais

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Giovanna Ribeiro Souto

Universidade Federal de Minas Gerais

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Patrícia Carlos Caldeira

Universidade Federal de Minas Gerais

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