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Dive into the research topics where Souichirou Kawazoe is active.

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Bioorganic & Medicinal Chemistry | 2009

Discovery of novel thiourea derivatives as potent and selective β3-adrenergic receptor agonists

Tatsuya Maruyama; Norio Seki; Kenichi Onda; Takayuki Suzuki; Souichirou Kawazoe; Masahiko Hayakawa; Tetsuo Matsui; Toshiyuki Takasu; Mitsuaki Ohta

In the search for potent and selective human beta3-adrenergic receptor (AR) agonists as potential drugs for the treatment of obesity and noninsulin-dependent (type II) diabetes, we prepared a novel series of phenoxypropanolamine derivatives containing the thiourea moiety and evaluated their biological activities at human beta3-, beta2-, and beta1-ARs. Among these compounds, 4-nitrophenylthiourea (18i) and 3-methoxyphenylthiourea (18k) derivatives were found to exhibit potent agonistic activity at the beta3-AR, with EC(50) values of 0.10 and 0.16 microM, respectively, and no agonistic activity for either the beta1- or beta2-AR. In addition, they showed significant hypoglycemic activity in a rodent diabetic model.


Archive | 1998

Novel pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi; Ryo Naito; Souichirou Kawazoe; Akira Toyoshima; Kazuhito Tanabe; Eiichi Nakai; Atsushi Ichikawa; Akiko Orita; Makoto Takeuchi


Archive | 1998

Pyrimidine-5-carboxamide derivatives

Hiroyuki Hisamichi; Ryo Naito; Souichirou Kawazoe; Akira Toyoshima; Kazuhito Tanabe; Eiichi Nakai; Atsushi Ichikawa; Akiko Orita; Makoto Takeuchi


Archive | 2002

Alpha-form or beta-form crystal of acetanilide derivative

Souichirou Kawazoe; Kenichirou Sakamoto; Yuji Awamura; Tatsuya Maruyama; Takayuki Suzuki; Kenichi Onda; Toshiyuki Takasu


Archive | 2001

Diazepane derivatives or salts thereof

Fukushi Hirayama; Hiroyuki Koshio; Tsukasa Ishihara; Norio Seki; Shunichiro Hachiya; Keizo Sugasawa; Ryota Shiraki; Yuji Koga; Yuzo Matsumoto; Takeshi Shigenaga; Souichirou Kawazoe


Archive | 1998

Pharmaceutical compound comprising a pyrazole derivative and methods of using the same for the treatment of calcium release-activated calcium channel associated diseases

Hirokazu Kubota; Yasuhiro Yonetoku; Keizou Sugasawa; Masashi Funatsu; Souichirou Kawazoe; Akira Toyoshima; Yoshinori Okamoto; Jun Ishikawa; Makoto Takeuchi


Archive | 2002

α-form or β-form crystal of acetanilide derivative

Souichirou Kawazoe; Kenichirou Sakamoto; Yuji Awamura; Tatsuya Maruyama; Takayuki Suzuki; Kenichi Onda; Toshiyuki Takasu


Archive | 1998

Nitrogenous heterocyclic derivatives

Seijiro Akamatsu; Eiji Kawaminami; Shinya Nagashima; Souichirou Kawazoe; Tetsuro Ogami; Ken-Ichi Suzuki; Yuzo Matsumoto; Minoru Okada


Chemical & Pharmaceutical Bulletin | 2001

Novel Malonamide Derivatives as αvβ3 Antagonists. Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with αvβ3

Shinya Nagashima; Seijiro Akamatsu; Eiji Kawaminami; Souichirou Kawazoe; Tetsuro Ogami; Yuzo Matsumoto; Minoru Okada; Ken-Ichi Suzuki; Shin-ichi Tsukamoto


Archive | 2001

Diazepan derivatives or salts thereof

Fukushi Hirayama; Hiroyuki Koshio; Tsukasa Ishihara; Norio Seki; Shunichiro Hachiya; Keizo Sugasawa; Ryota Shiraki; Yuji Koga; Yuzo Matsumoto; Takeshi Shigenaga; Souichirou Kawazoe

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