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Sow-mei L. Chen

American Cyanamid

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Featured researches published by Sow-mei L. Chen.

Prostaglandins | 1979

Prostaglandins and congeners XXIII (1). Synthesis of 15-deoxy-16-hydroxy-16-methylprostaglandins. The importance of the C13-C14 trans double bond for bronchodilator activity

Sow-mei L. Chen; Charles V. Grudzinskas; Franz Dessy

The synthesis and bronchodilator activity in the guinea pig of several 15-deoxy-16-hydroxy-16-methylprostaglandin analogs is described. The E2 (VIa) and E1 (VIb) analogs are potent bronchodilators comparable in activity to the natrual prostaglandins, but possessing a longer duration of effect. Replacement of the C13--C14 trans double bond by a cis double bond or an ethylene linkage causes a substantial diminishment of this activity.

Journal of Organic Chemistry | 1978

Prostaglandins and congeners. 19. Vinylstannanes: useful organometallic reagents for the synthesis of prostaglandins and prostaglandin intermediates

Sow-mei L. Chen; Robert E. Schaub; Charles V. Grudzinskas

Journal of Organic Chemistry | 1980

Prostaglandins and congeners. 27. Synthesis of biologically active 16-halomethyl derivatives of 15-deoxy-16-hydroxyprostaglandin E2

Sow-mei L. Chen; Charles V. Grudzinskas

Archive | 1980

Various- 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins

Middleton Brawner Floyd; Martin J. Weiss; Charles V. Grudzinskas; Sow-mei L. Chen

Archive | 1977

Novel vinyl-stannyl derivatives

Middleton Brawner Floyd; Charles V. Grudzinskas; Sow-mei L. Chen

ChemInform | 1979

PROSTAGLANDINS AND CONGENERS. 19. VINYLSTANNANES- USEFUL ORGANOMETALLIC REAGENTS FOR THE SYNTHESIS OF PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES

Sow-mei L. Chen; Robert E. Schaub; C. V. Grudzinskas

Archive | 1980

15-Deoxy-16-hydroxy-16-chloromethyl or bromomethyl prostaglandins of the E and F series

Sow-mei L. Chen; Charles V. Grudzinskas

Archive | 1980

16-Hydroxy-5-iodo-prostacyclin analogs of the 1 series

Charles V. Grudzinskas; Sow-mei L. Chen; Allan Wissner

Archive | 1978

Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-carbinol prostaglandins of the A, D, E and F series

Middleton Brawner Floyd; Martin J. Weiss; Charles V. Grudzinskas; Sow-mei L. Chen

Archive | 1981

Prostacyclin analogs of the 1 series and related analogs

Charles V. Grudzinskas; Allan Wissner; Sow-mei L. Chen

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Charles V. Grudzinskas

American Cyanamid

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Allan Wissner

American Cyanamid

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Middleton Brawner Floyd

American Cyanamid

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Martin J. Weiss

American Cyanamid

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Robert E. Schaub

American Cyanamid

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