Spyros D. Georgatos
Howard Hughes Medical Institute
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FEBS Letters | 1997
Fotini Gounari; Niki Karagianni; Antoaneta Mincheva; Peter Lichter; Spyros D. Georgatos; Volker Schirrmacher
Filensin and phakinin are two lens‐specific members of the intermediate filament (IF) superfamily of proteins. They coassemble to form a beaded submembraneous filamentous network, the beaded filaments (BFs). The low sequence homology and differences in assembly compared to other IF proteins do not allow their classification in any of the five IF subgroups. The organization of the phakinin gene exon/intron boundaries provides evidence that this partner may be sharing a common origin with type I cytokeratin genes. Here we report the molecular cloning, sequence and characterization of the mouse filensin gene. The filensin gene consists of 8 exons and 7 introns, with 6 introns interrupting its rod domain in a highly conserved manner characteristic of type III IF genes, like vimentin, desmin, or peripherin. Of the two tail domain exons the one adjacent to the rod domain, compares to exon 7 of the non‐neuronal cytoplasmic IF gene of helix aspersa and to the lamin region bridging the end of the rod domain to the nuclear localization signal. Altogether, these observations indicate that the lens beaded filaments form an independent class of IF.
Journal of Cell Biology | 1987
Spyros D. Georgatos; Giinter Blobel
Journal of Cell Biology | 1987
Spyros D. Georgatos; Giinter Blobel
Proceedings of the National Academy of Sciences of the United States of America | 1987
Spyros D. Georgatos; Klaus Weber; N Geisler; G Blobel
Cell | 1991
Karima Djabali; Marie-Madeleine Portier; François Gros; Günter Blobel; Spyros D. Georgatos
Journal of Cell Biology | 1991
Andreas Merdes; Mariann Brunkener; Heinz Horstmann; Spyros D. Georgatos
Journal of Cell Biology | 1993
Andreas Merdes; Fotini Gounari; Spyros D. Georgatos
Journal of Cell Biology | 1996
George Goulielmos; Fotini Gounari; Susann Remington; S Müller; M Häner; Ueli Aebi; Spyros D. Georgatos
Journal of Cell Biology | 1993
Fotini Gounari; Andreas Merdes; Roy A. Quinlan; John F. Hess; Paul G. FitzGerald; Christos A. Ouzounis; Spyros D. Georgatos
Proceedings of the National Academy of Sciences of the United States of America | 1988
Spyros D. Georgatos; Christos Stournaras; Günter Blobel