Sri Hartati Yuliani

Scarless wound healing gel with Binahong (Anredera cordifolia (Ten) Steenis) leaves extract and celecoxib as the active ingredients

An optimum formula for wound-healing gel containing ethanolic extract of Binahong (Anredera cordifolia (Ten) Steenis) leaves had been developed previously. In addition, inhibiting cyclooxygenase-2 (COX-2) enzyme during the wound-healing process was reported to minimize the formation of scars. In this article, the preliminary research on the development of the scarless wound healing gel formula by adding COX-2 inhibitor celecoxib into wound healing gel is presented. Additional cyclooxygenase-2 inhibitor celecoxib in wound healing gel containing ethanolic extract of binahong leaves showed wound healing with the statistically smaller size of newly formed epidermis compared to the optimum formula of wound healing gel containing ethanolic extract of binahong without additional celecoxib. This indicates that scarless wound healing could be obtained by the application of gel containing ethanolic extract of binahong leaves and cyclooxygenase-2 inhibitor.