Srihari Mahadev

Is Dietitian Use Associated with Celiac Disease Outcomes

A gluten-free diet (GFD) is the treatment for celiac disease (CD), but due to its complexity, dietitian referral is uniformly recommended. We surveyed patients with CD to determine if dietitian use is associated with quality of life, symptom severity, or GFD adherence. The survey utilized three validated CD-specific instruments: the CD quality of life (CD-QOL), CD symptom index (CSI) and CD adherence test (CDAT). Four hundred and thirteen patients with biopsy-proven CD were eligible for inclusion. The majority (77%) were female and mean BMI was 24.1. Over three-quarters of patients (326, 79%) had seen a dietitian, however, 161 (39%) had seen a dietitian only once. Age, sex, and education level were not associated with dietitian use; nor was BMI (24.6 vs. 24.0, p = 0.45). On multivariate analysis, adjusting for age gender, education, duration of disease, and body mass index, dietitian use was not associated with CD-QOL, CSI, or CDAT scores. Our survey did not show an association between dietitian use and symptom severity, adherence, or quality of life. Delay in diagnosis was associated with poorer outcomes. This is a preliminary study with several limitations, and further prospective analysis is needed to evaluate the benefits and cost-effectiveness of dietitian-referral in the care of celiac disease patients.

Factors associated with villus atrophy in symptomatic coeliac disease patients on a gluten-free diet

Duodenal injury persists in some coeliac disease patients despite gluten‐free diet, and is associated with adverse outcomes.

Quality of Life in Screen-detected Celiac Disease Patients in the United States.

Background and Aims:Celiac disease (CD) is increasingly diagnosed through screening of at-risk groups (relatives of individuals and associated autoimmune disorders). The impact of diagnosis and treatment on screen-detected CD patients is poorly studied, particularly in the United States. We therefore compared the quality of life (QOL) between screen-detected and symptom-detected CD patients. Methods:Patients with a known diagnosis of CD were invited to complete 3 validated survey instruments: the CD Quality of Life (CDQOL), the CD Adherence Test for dietary adherence and the general Psychological General Well-Being index. In addition, demographic details, mode of presentation, and compliance with gluten-free diet (GFD) were assessed. Results:The overall response rate was high at 69%. Of 226 responses received, 211 were eligible for inclusion; the median age was 47, and the median duration of GFD was 4 years. One third of the sample (71, 34%) was screen detected. Of these, 57 (80%) had a relative diagnosed with CD, whereas 14 (20%) had an associated condition. Despite being screen detected, 49 (69%) reported symptoms before diagnosis. GFD adherence was excellent and did not differ between groups. Overall, there were no significant differences between screen-detected and symptom-detected patients with regard to CDQOL, CD Adherence Test, and Psychological General Well-Being scores. Conclusions:Screen-detected and symptom-detected CD patients do not differ with regard to QOL or disease adherence as measured by validated disease-specific instruments. A high proportion of screen-detected patients reported symptoms before diagnosis, which often improve with GFD.

Endoscopic septotomy: an effective approach for internal drainage of sleeve gastrectomy-associated collections.

Background and study aims Staple-line leaks occur in 1 % - 7 % of patients who undergo sleeve gastrectomy, and can be challenging to treat. The success of endoscopic approaches decreases as leaks develop into chronic sinus tracts. Endoscopic septotomy has been used to facilitate healing of refractory leaks by incision and enlargement of the tract to allow direct communication with the gastric lumen and internal drainage. Patients and methods We reviewed the technique and outcomes among patients who underwent endoscopic septotomy at two centers for the management of sleeve gastrectomy-associated gastric fistulas and perigastric collections refractory to occlusive endoscopic therapies. Results Nine patients underwent endoscopic septotomy at a mean of 8.6 weeks after leak diagnosis, following failure of percutaneous and conventional endoscopic modalities. Perigastric collections ranged from 3 cm to 10 cm in size. The mean procedure time for endoscopic septotomy was 87.2 minutes. Multiple endoscopic septotomy procedures (mean 2.3, range 1 - 4) were required to achieve radiological resolution. The mean follow-up period was 21.2 weeks, and all nine patients achieved symptom resolution without the need for surgery. Bleeding at the time of endoscopic septotomy occurred in three patients, and was managed with endoscopic clips and did not require transfusion. No other adverse events or delayed complications were recorded. Conclusions Endoscopic septotomy appears to be a safe and effective technique for the management of sleeve gastrectomy-associated fistulae and collections, including those refractory to other endoscopic and percutaneous methods.

Rates of Suboptimal Preparation for Colonoscopy Differ Markedly Between Providers: Impact on Adenoma Detection Rates.

Goals: We sought to determine if providers who have higher standards for optimal bowel preparation might be more fastidious in their examination of the colon and, therefore, have higher adenoma detection rates (ADRs). Background: ADRs are a reliable and objective marker of colonoscopy performance. Suboptimal bowel preparation impacts upon adenoma detection; however, physicians have varying standards for grading bowel preparation. Study: Endoscopy reports of patients who underwent screening colonoscopy in 2011 at 1 academic medical center were reviewed. Bowel preparations labeled “fair,” “poor,” or “unsatisfactory” were considered suboptimal. The ADR was calculated for each endoscopy provider and was correlated with the provider’s suboptimal preparation rate. Logistic regression was used to determine independent predictors of adenoma detection. Results: 1649 examinations from 11 separate gastroenterologists were included. Preparation was suboptimal in 22% of examinations overall. The rate of suboptimal preparations varied widely among providers, ranging from 3% to 40%. Overall ADR was 23%, with a range of 13% to 31%. Providers’ suboptimal preparation rate was not significantly correlated with ADR (r=−0.22, P=0.51). After adjusting for age and sex, adenoma detection was not associated with provider suboptimal preparation rate (P=0.28). Conclusions: Rates of suboptimal preparation vary widely between providers, but were not correlated with ADR. This suggests that a high suboptimal preparation rate is not a marker of higher quality standards and expectations by the provider. The impact of physician personality traits on colonoscopy performance requires further study.

Systematic review with meta‐analysis: the prevalence of coeliac disease in patients with osteoporosis

Earlier studies have produced highly varying risk estimates for the prevalence of coeliac disease (CD) in osteoporosis.

Adenoma Detection is Increased in the Setting of Melanosis Coli

Goals: To compare the adenoma detection rate (ADR) during colonoscopy in patients with melanosis coli against matched controls without melanosis. Background: Melanosis coli is a colonoscopic finding in which the colon wall appears darkly pigmented, most often due to extended laxative use, and is considered benign. The pigmentation spares adenomas, which should therefore be more readily detectable in melanosis coli. Study: We identified all patients with melanosis on colonoscopy at our institution over a 5-year period. We matched each patient with 2 controls by age, gender, and endoscopist. We compared the prevalence of adenomas between groups, and used multivariable analysis, adjusting for procedure indication and bowel preparation quality, to determine the independent association of melanosis with adenoma detection. Results: At least 1 adenoma was detected in 34.7% of melanosis patients and 26.5% of controls [odds ratio (OR)=1.52; 95% confidence interval (CI), 1.04-2.24; P=0.03]. On multivariable analysis, the presence of melanosis remained associated with increased adenoma detection (OR=1.56; 95% CI, 1.05-2.33; P=0.03). Melanosis patients were more likely to have an adenoma ⩽5 mm (OR=1.62; 95% CI, 1.04-2.51; P=0.03), but not adenomas 6 to 9 mm or ≥10 mm. Conclusions: Melanosis coli is associated with a significant increase in ADR during colonoscopy compared with controls. The increased visibility of adenomas given their contrast with the pigmented background is a likely explanation. Future efforts to identify bowel preparation agents that can induce a similar effect could improve ADRs during colonoscopy.

Editorial: risk factors for persistent villus atrophy in coeliac disease – is it time to reconsider definitions for refractory coeliac disease? Authors' reply

First, reasons for the high rates of persistent villus atrophy are not clear. This may relate to variable compliance but no data regarding dietary compliance were collected. In selecting symptomatic patients, this may have also selected a more severe phenotype although the correlation between gastrointestinal symptoms and clinical phenotype is debatable. This is further reinforced by the present study where some symptoms were inversely associated with villus atrophy. The second point is the question of refractory coeliac disease (RCD). Based on current definitions, up to two-thirds of the recruited participants would be defined as having refractory coeliac disease – a condition reported to be uncommon. This might be interpreted as cause for alarm, but a more pragmatic interpretation would be that the existing definitions of RCD need to be interpreted with caution. The authors have provided important insights into associations with villus atrophy which might allow clinicians to target specific groups for more intensive endoscopic follow-up. The study also highlights shortcomings of current definitions of refractory coeliac disease which can increase patient anxiety. Ideally, similar large scale studies should be prospective in design, collect thorough data on dietary adherence, and assess both long-term disease outcomes and markers of refractory coeliac disease such as T-cell receptor clonality. ACKNOWLEDGEMENT Declaration of personal and funding interests: None.

Determinants of Patient Satisfaction in Celiac Disease Care

Background and Goals: There are little data examining patient satisfaction with celiac disease (CD) care. We sought to assess how satisfied patients are with their CD care, and to determine the influencing factors. Study: We distributed an online questionnaire to adults receiving programmatic updates from a CD referral center, querying aspects of CD care and using disease-specific validated instruments to measure quality of life and dietary adherence. The univariable and multivariable analyses were performed using satisfaction as a binary outcome comparing grouped “satisfied” and “very satisfied” respondents to “neutral,” “dissatisfied,” and “very dissatisfied” respondents. Results: Three hundred eighty-seven (22%) individuals completed the survey, and 229 met the inclusion criteria of biopsy-proven CD. Seventy-nine individuals (34.5%) reported being “very satisfied” with their CD care, 82 (35.8%) “satisfied,” 46 (20.1%) “neutral,” 14 (6.1%) “dissatisfied,” and 8 (3.5%) “very dissatisfied.” On multivariable analysis, reporting that physicians spend ample time managing CD needs (P=0.013), and having CD-antibody levels checked yearly (P=0.003), were positive predictors of patient satisfaction. Factors that were not correlated with patient satisfaction included symptom severity (P=0.268), quality of life (P=0.13), and following with a CD specialist (P=0.139). Conclusions: The majority of patients we surveyed were satisfied with their CD care. We found that patients report higher satisfaction when they feel physicians spend time caring for their CD needs and when they receive annual CD-antibody testing. On the basis of our study, these factors are more important than disease severity, seeing a CD specialist, and quality of life in determining patient satisfaction with CD care.