Srinivasa Rao Cheruku
University of Nebraska Medical Center
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Publication
Featured researches published by Srinivasa Rao Cheruku.
International Immunopharmacology | 2003
Sam D. Sanderson; Srinivasa Rao Cheruku; Maniyan Padmanilayam; Jonathan L. Vennerstrom; Geoffrey M. Thiele; Matthew I. Palmatier; Rick A. Bevins
This paper describes the synthesis of a nicotine hapten (Nic) that possesses a carboxyl sidearm functional group allowing for conjugation to a peptide via amide bond formation. Nic was attached to the N-terminal amino group of a 19-residue peptide composed of a conformationally biased agonist of human C5a (YSFKPMPLaR), which is used as a molecular adjuvant and a B cell epitope of human MUC1 glycoprotein (YKQGGFLGL) to yield a peptide-based nicotine vaccine, NicYKQGGFLGLYSFKPMPLaR. Rats immunized with this vaccine were significantly less sensitive to behavioral effects (a Pavlovian discrimination task) induced by their exposure to high concentrations of nicotine (0.4 mg/kg) relative to their non-vaccinated counterparts. The attenuation of these nicotine-induced behavioral effects emanated from the presence of nicotine-specific antibodies (Abs) that were present in the sera of vaccinated rats even after their repeated exposure to high concentrations of nicotine during the time required to perform the behavioral assays. These results suggest that immunization with NicYKQGGFLGLYSFKPMPLaR in the absence of adjuvant is an effective means of inducing a nicotine-specific Ab response, which is capable of attenuating nicotine-induced behavioral/psychoactive effects.
Tetrahedron Letters | 2003
Srinivasa Rao Cheruku; Maniyan Padmanilayam; Jonathan L. Vennerstrom
A mild and efficient synthesis of 2,2-dialkyl-3,5-diaryl-2H-pyrroles is described. Treatment of 2,2-dialkyl-3,5-diarylpyrrolidines with DDQ in dioxane for 12–24 h at rt afforded the corresponding 2H-pyrroles in 55–81% overall yields.
ACS Medicinal Chemistry Letters | 2011
Brian A. Lanman; Victor J. Cee; Srinivasa Rao Cheruku; Mike Frohn; Jennifer E. Golden; Jian Lin; Mercedes Lobera; Yael Marantz; Kristine M. Muller; Susana C. Neira; Alexander J. Pickrell; Dalia Rivenzon-Segal; Nili Schutz; Anurag Sharadendu; Xiang Yu; Zhaoda Zhang; Janet Buys; Mike Fiorino; Anu Gore; Michelle Horner; Andrea Itano; Michele McElvain; Scot Middleton; Michael Schrag; Hugo M. Vargas; Han Xu; Yang Xu; Xuxia Zhang; Jerry Siu; Roland W. Bürli
Optimization of a benzofuranyl S1P1 agonist lead compound (3) led to the discovery of 1-(3-fluoro-4-(5-(2-fluorobenzyl)benzo[d]thiazol-2-yl)benzyl)azetidine-3-carboxylic acid (14), a potent S1P1 agonist with minimal activity at S1P3. Dosed orally at 0.3 mg/kg, 14 significantly reduced blood lymphocyte counts 24 h postdose and attenuated a delayed type hypersensitivity (DTH) response to antigen challenge.
Journal of Medicinal Chemistry | 2006
Oren M. Becker; Dale S. Dhanoa; Yael Marantz; Dongli Chen; Sharon Shacham; Srinivasa Rao Cheruku; Alexander Heifetz; Pradyumna Mohanty; Merav Fichman; Anurag Sharadendu; Raphael Nudelman; Michael Kauffman; Silvia Noiman
Archive | 2007
Roland W. Bürli; Victor J. Cee; Jennifer E. Golden; Brian A. Lanman; Susana C. Neira; Ashis Saha; Nili Schutz; Xiang Yu; Dilara McCauley; Mercedes Lobera; Yael Marantz; Jian Lin; Srinivasa Rao Cheruku; Pini Orbach; Anurag Sharadendu; Robert C. Penland; Kimberley Gannon; Sharon Shacham; Silvia Noiman; Oren M. Becker; Zhaoda Zhang
Bioorganic & Medicinal Chemistry | 2006
Yuxiang Dong; Yuanqing Tang; Jacques Chollet; Hugues Matile; Sergio Wittlin; Susan A. Charman; William N. Charman; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Bernard Scorneaux; Saroj Bajpai; Scott A Alexander; Xiaofang Wang; Maniyan Padmanilayam; Srinivasa Rao Cheruku; Reto Brun; Jonathan L. Vennerstrom
Journal of Medicinal Chemistry | 2003
Srinivasa Rao Cheruku; Souvik Maiti; Arnulf Dorn; Bernard Scorneaux; Apurba K. Bhattacharjee; William Y. Ellis; Jonathan L. Vennerstrom
Archive | 2004
Dale S. Dhanoa; Oren M. Becker; Silvia Noiman; Sekar A. Reddy; Srinivasa Rao Cheruku; Rosa E. Melendez; Anurag Sharadendu; Dongli Chen; Yael Marantz; Sharon Shacham; Alexander Heifetz; Boaz Inbal; Venkitasamy Kesavan; Shay Bar-Haim
Archive | 2003
Dale S. Dhanoa; Oren M. Becker; Silvia Noiman; Venkitasamy Kesavan; Anurag Sharadendu; Pradyumna Mohanty; Dongli Chen; Srinivasa Rao Cheruku; Alexander Heifetz; Ori Kalid; Yael Marantz; Raphael Nudelman; Sharon Sbacham; Shay Bar-Haim
Archive | 2003
Dale S. Dhanoa; Oren M. Becker; Dongli Chen; Srinivasa Rao Cheruku; Alexander Heifetz; Ori Kalid; Venkitasamy Kesavan; Yael Marantz; Pradyumna Mohanty; Silvia Noiman; Raphael Nudelman; Sharon Shachem; Anurag Sharadendu; Shay Bar-Haim