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Clinical Therapeutics | 2000

Ibuprofen Liquigel for Oral Surgery Pain

Elliot V. Hersh; Lawrence M. Levin; Stephen A. Cooper; Geraldine Doyle; Joel Waksman; David Wedell; Douglas Hong; Stacey A. Secreto

BACKGROUND Ibuprofen liquigel is a solubilized potassium ibuprofen 200-mg gelatin capsule formulation that was approved for over-the-counter use in 1995. OBJECTIVE This study compared the analgesic efficacy and tolerability of ibuprofen liquigel 200 mg, ibuprofen liquigel 400 mg, acetaminophen caplets 1000 mg, and placebo in patients experiencing moderate or severe pain after surgical removal of impacted third molars. METHODS This randomized, double-blind, parallel-group, 6-hour study was conducted in 210 patients experiencing moderate or severe postoperative pain. Ratings of pain intensity and pain relief were recorded every 15 minutes for the first hour, at 90 and 120 minutes, and then hourly through hour 6. The onsets of first perceptible relief and meaningful relief were recorded using 2 stopwatches. An analysis of variance model was employed to test for significant differences (P < or = 0.05) between treatment groups with respect to pain relief, pain intensity difference, total pain relief (TOTPAR), and summed pain intensity difference (SPID). Stopwatch measures were analyzed using the Cox proportional hazards model. Drug tolerability was assessed by monitoring the occurrence of adverse events. RESULTS During the first 2 hours of the study (TOTPAR 2 and SPID 2), all active treatments were significantly more efficacious than placebo (P < 0.001), with ibuprofen liquigel 200 and 400 mg significantly more efficacious than acetaminophen 1000 mg (P < 0.05 and P < 0.01, respectively). For the entire duration of the study (TOTPAR 6 and SPID 6), only the 2 doses of ibuprofen liquigel were significantly more efficacious than placebo (P < 0.001). Ibuprofen liquigel 200 and 400 mg were also significantly more efficacious than acetaminophen 1000 mg on the summary measures TOTPAR 6 and SPID 6 (P < 0.01 and P < 0.001, respectively). Analysis of the stopwatch data revealed that all active treatments displayed significantly more rapid onsets to confirmed first perceptible relief (P < 0.001 to < 0.05) and meaningful relief (P < 0.001 to < 0.01) than did placebo, with ibuprofen liquigel 400 mg displaying a significantly more rapid onset to meaningful relief than acetaminophen 1000 mg (P < 0.05) and a significantly more rapid onset to confirmed first perceptible relief than acetaminophen 1000 mg (P < 0.001) and ibuprofen liquigel 200 mg (P < 0.01). All adverse events were considered mild or moderate, with an overall incidence of 11.5% in the ibuprofen liquigel 200-mg group, 6.8% in the ibuprofen liquigel 400-mg group, 19.0% in the acetaminophen 1000-mg group, and 25.9% in the placebo group. CONCLUSIONS Ibuprofen liquigel provided greater peak and overall analgesic effects and a more rapid onset to analgesia than did acetaminophen 1000 mg.


Clinical Therapeutics | 2017

Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa

Steven Wang; Helen Giannakopoulos; Jamie Lowstetter; Laura Kaye; Catherine S. Lee; Stacey A. Secreto; Vanessa Ho; Matthew Hutcheson; John T. Farrar; Ping Wang; Geraldine Doyle; Stephen A. Cooper; Elliot V. Hersh

PURPOSE This study evaluated changes in methemoglobin and oxygen saturation concentrations after the administration of recommended doses of 14% benzocaine alone or 14% benzocaine combined with 2% tetracaine. METHODS American Society of Anesthesiology class 1 and 2 subjects (n = 40) were enrolled in this modified crossover study. Subjects were administered 0.2 mL of 14% benzocaine alone, 0.2 mL of 14% benzocaine plus 2% tetracaine, or 0.4 mL of 14% benzocaine plus 0.2% benzocaine to their cheek mucosa. Venous blood (5 mL) was drawn from the antecubital fossa before and 60 minutes after drug application for methemoglobin analyses. Oxygen saturation was also recorded via pulse oximetry at baseline and every 10 minutes through 60 minutes after drug application. FINDINGS Methemoglobin and oxygen saturation levels did not change from baseline after the administration of benzocaine alone or when combined with tetracaine. IMPLICATIONS Recommended doses of benzocaine or benzocaine combined with tetracaine when applied to the cheek mucosa do not induce even clinically insignificant elevations in methemoglobin levels. Metered dosing, such as that used in this study, can help avoid this overdose phenomena with these drugs. ClinicalTrials.gov identifier: NCT02908620.


Journal of the American Dental Association | 2006

The pharmacokinetics and cardiovascular effects of high-dose articaine with 1:100,000 and 1:200,000 epinephrine

Elliot V. Hersh; Helen Giannakopoulos; Lawrence M. Levin; Stacey A. Secreto; Paul A. Moore; Carrie Peterson; Matthew Hutcheson; Mohammed Bouhajib; Ari Mosenkis; Raymond R. Townsend


Journal of the American Dental Association | 2008

Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults

Elliot V. Hersh; Paul A. Moore; Athena Papas; J. Max Goodson; Laura A. Mavalta; Siegfried Rogy; Bruce Rutherford; John A. Yagiela; Jeffrey Bennett; Hafsteinn Eggertsson; Jodie L. Jarrett; Melissa S. Mau; Sean G. Boynes; Anne L. Lemak; Jayme Zovko; Maribeth Krzesinski; O. Basil Aboosi; Andres Pinto; Stacey A. Secreto; Bridget Gallagher; Morton Rosenberg; Mabi Singh; N. Pradhan; Medha Singh; Ted P. Raybould; John Pfail; David V. Valauri; Yordanka K. Ivanova; Sharon M. Gordon; Alfredo Arribas


Journal of the American Dental Association | 2012

The cardiovascular effects and pharmacokinetics of intranasal tetracaine plus oxymetazoline: Preliminary findings

Helen Giannakopoulos; Lawrence M. Levin; Joli C. Chou; Anthony T. Cacek; Matthew Hutcheson; Stacey A. Secreto; Paul A. Moore; Elliot V. Hersh


The Journal of clinical dentistry | 2003

Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain.

Elliot V. Hersh; Scott S. DeRossi; Katharine N. Ciarrocca; Stacey A. Secreto; Annahita Ghassemi


Journal of the American Dental Association | 2012

Local AnesthesiaThe cardiovascular effects and pharmacokinetics of intranasal tetracaine plus oxymetazoline: Preliminary findings

Helen Giannakopoulos; Lawrence M. Levin; Joli C. Chou; Anthony T. Cacek; Matthew Hutcheson; Stacey A. Secreto; Paul A. Moore; Elliot V. Hersh


Clinical Therapeutics | 2011

Double-Blind, Placebo-Controlled, Randomized Pilot Study of Cerebral Blood Flow Patterns Employing SPECT Imaging in Dental Postsurgical Pain Patients With and Without Pain Relief

Andrew B. Newberg; Elliot V. Hersh; Lawrence M. Levin; Helen Giannakopoulos; Stacey A. Secreto; Nancy Wintering; John T. Farrar


The Journal of clinical dentistry | 2005

A study of benzocaine gel dosing for toothache.

Elliot V. Hersh; Eric T. Stoopler; Stacey A. Secreto; Scott S. DeRossi


The Journal of clinical dentistry | 1997

Ketoprofen Dental Pain Study.

Levin Lm; Stephen A. Cooper; Betts Nj; Wedell D; Hermann Dg; Lamp C; Stacey A. Secreto; Elliot V. Hersh

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Elliot V. Hersh

University of Pennsylvania

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Lawrence M. Levin

University of Pennsylvania

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Paul A. Moore

University of Pittsburgh

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Stephen A. Cooper

University of Pennsylvania

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Andres Pinto

University of Pennsylvania

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John T. Farrar

University of Pennsylvania

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Scott S. DeRossi

University of Pennsylvania

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