Stanton Siu

Risk of Coronary Disease in the South Asian American Population

To the Editor: Defined as persons of Indian, Pakistani, Bangladeshi, or Sri Lankan ancestry, the South Asian (SA) population is believed to have a higher risk of coronary artery disease (CAD) than that of other ethnic groups [(1–6)][1]. Substantial evidence comes mostly from prevalence data or

Ethnicity and risk of hospitalization for asthma and chronic obstructive pulmonary disease.

PURPOSE To identify ethnic differences for risk of hospitalization for asthma and chronic obstructive pulmonary disease (COPD). METHODS We undertook a cohort study with 126,019 participants: 55% whites, 27% blacks, 11% Asians, and 4% Hispanics. To estimate asthma and COPD risk, we used Cox proportional hazards models adjusted for age, sex, body mass index, education, smoking, and alcohol intake. End points were hospitalizations for asthma or COPD. RESULTS Compared with whites, relative risks (RR) with 95% confidence intervals (95% CI) for asthma among other groups were: blacks, 1.7 (1.4-2.0); Hispanics, 0.9 (0.6-1.4); and Asians, 1.6 (1.2-2.1). Among Asians, increased risk was concentrated in Filipino men and women and South Asian men. For COPD, whites were at highest risk; RR of blacks was 0.9 (0.7-1.0); Hispanics, 0.6 (0.3- 0.9); and Asians, 0.4 (0.3-0.6). COPD risk among Asians was lowest in Chinese with RR of 0.3 (0.1-0.5). CONCLUSIONS Ethnic disparities in risk of asthma and COPD as well as between both diseases exist, especially for Asian Americans, who have high asthma risk and low COPD risk. While residual confounding for smoking or other environmental factors could be partially responsible, genetic factors in Asians may be involved in decreased COPD risk.