Stefan Adam

Filled fluorosilicone as matrix material for ion-selective membranes

Thin film and containment sensors with fluorosilicone as the matrix material for the ion-selective membrane are described. Potassium-, sodium-and calcium-selective sensors, with response characteristics similar to those of a conventional ISE using PVC-matrix membranes, have been realized. The notable features of the new membrane are a good adhesion and the improved mechanical strength compared with PVC matrix membranes. Furthermore, it has an optimal conductivity and a higher relative permittivity than ‘conventional’ silicones.

Minimally invasive suction sampling unit for interstitial fluid enhanced by electroosmotic mass transport

Background: Minimally invasive glucose monitoring is an important tool for a better management of diabetes in order to avoid long-term complications. Methods: A vacuum operated ultrafiltration sampling unit for interstitial fluid (ISF) with integrated electroosmotic flow enhancement has been developed. The novel device was tested with three non-diabetic, healthy volunteers. Results: Flow measurements showed an increased ISF transport depending on the applied electrical current. Preliminary online glucose measurements showed reasonable results. Conclusion: Electroosmotically enhanced ISF harvesting seems to be a promising approach for generating minimally invasive glucose monitoring devices, although results have shown significant ISF flow for the applied microsensors.