Stephan Rauthe
University of Würzburg
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Publication
Featured researches published by Stephan Rauthe.
Journal of Clinical Microbiology | 2013
Dennis Tappe; Karen Ernestus; Stephan Rauthe; Christoph Schoen; Matthias Frosch; Andreas Müller; August Stich
Recently, Geosentinel has been notified of patients with acute muscular Sarcocystis-like infections related to travel to Tioman Island, peninsular Malaysia ([1][1]). The outbreak started in the summer of 2011, and the initial patients were seen in Wurzburg, Germany ([2][2]). The epidemic is
Clinical Oral Investigations | 2011
Eva Krauss; Stephan Rauthe; Stefan Gattenlöhner; Tobias Reuther; Michael Kochel; Ulrike Kriegebaum; Alexander C. Kübler; Urs D.A. Müller-Richter
Oral squamous cell carcinoma develops continuously out of predamaged oral mucosa. For the physician and pathologist, difficulties arise in distinguishing precancerous from cancerous lesions. MAGE-A antigens are tumor antigens that are found solely in malignant transformed cells. These antigens might be useful in distinguishing precancerous from cancerous lesions. The aim of this study was to verify this assumption by comparing MAGE-A expression in benign, precancerous, and cancerous lesions of the oral mucosa. Retrospectively, biopsies of different oral lesions were randomly selected. The lesions that were included are 64 benign oral lesions (25 traumatic lesions (oral ulcers), 13 dental follicles, and 26 epulis), 26 oral lichen planus, 123 epithelial precursor lesions (32 epithelial hyperplasia found in leukoplakias, 24 epithelial dysplasia found in leukoplakias, 26 erythroplasia with oral epithelial dysplasia, and 41 carcinomas in situ in erythroleukoplakias). The lesions were immunohistochemically stained with the poly-MAGE-A antibody 57B, and the results were compared. Biopsies of oral lichen planus, oral ulcers, dental follicles, epulis, and leukoplakia without dysplasia showed no positive staining for MAGE-A antigens. Leukoplakia with dysplasia, dysplasia, and carcinomata in situ displayed positive staining in 33%, 65%, and 56% of the cases, respectively. MAGE-A antigens were not detectable via immunohistochemistry in benign lesions of the oral mucosa. The staining rate of dysplastic precancerous lesions or malignant lesions ranged from 33% to 65%. The MAGE-A antigens might facilitate better differentiation between precancerous and cancerous lesions of the oral mucosa.
Clinical Oral Investigations | 2010
Urs D.A. Müller-Richter; Albert Dowejko; Silvia Peters; Stephan Rauthe; Tobias Reuther; Stefan Gattenlöhner; Torsten E. Reichert; Oliver Driemel; Alexander C. Kübler
MAGE-A antigens are only expressed on tumor cells. The aim of this study was to identify their expression in patients with oral squamous cell carcinoma (OSCC). Forty-seven patients with primary OSCC was selected retrospectively. Histo-pathological sections were stained immunohistochemically with MAGE-A antibody 57B. The results were evaluated regarding tumor size (T), lymph-node metastasis (N), blood vessel infiltration (V), lymph vessel infiltration (L), grading (G), and sex. MAGE-A antigens were expressed in 55% of all patients. Expression increased with tumor size (T1 = 56%; T2 = 44%; T3 = 67%; T4 = 71%). Lymph-node metastasis had no influence (N0 and N1 about 50%). Tumors with blood and lymph vessel infiltration had higher expression (V0 = 50%; V1 = 100%; L0 = 46%; L1 = 71%). Less-differentiated tumors showed higher rates (G1 = 50%; G2 = 45%; G3 = 83%). OSCC in men were positive in 62% and in women in 38%. MAGE-A antigens are frequently expressed in OSCC. Their expression seems to increase with tumor dedifferentiation.
Journal of Obstetrics and Gynaecology Research | 2011
Bernhard Niederle; Stephan Rauthe; Jörg B. Engel; Matthias Krockenberger; Johannes Dietl; A Hönig
A case of a papillary squamotransitional cell carcinoma (PSTCC) of the vagina with a follow‐up of 3 years is presented here. The characteristics of this case support a squamous rather than urothelial origin of this rare entity. Unlike its counterparts in the cervix uteri, the clinical behavior of vaginal PSTCC is more favorable than squamous cell carcinoma. Histological and clinical features are compared to those of previously described cases of vaginal and cervical PSTCC.
Signal Transduction | 2006
Brigitte Santner-Nanan; Friederike Berberich-Siebelt; Zheng Xiao; Niklas Poser; Helga Sennefelder; Stephan Rauthe; Duttu S. Vallabhapurapu; Ingolf Berberich; Anneliese Schimpl; Hans-Wolfgang Kreth; Ralph Nanan
Cases Journal | 2008
Engelbert Schröpfer; Stephan Rauthe; Thomas Meyer
European Journal of Pediatrics | 2011
Alexandra Unzicker; Veronique Pingault; Thomas Meyer; Stephan Rauthe; Ansgar Schütz; Steffen Kunzmann
Oncology Letters | 2016
Stefan Hartmann; Muna Brisam; Stephan Rauthe; Oliver Driemel; Roman C. Brands; Andreas Rosenwald; Alexander C. Kübler; Urs D.A. Müller-Richter
Clinical Oral Investigations | 2017
Roman C. Brands; Olga Köhler; Stephan Rauthe; Stefan Hartmann; Harald Ebhardt; Axel Seher; Christian Linz; Alexander C. Kübler; Urs D.A. Müller-Richter
Journal of Cranio-maxillofacial Surgery | 2015
Stefan Hartmann; Romy U.N. Kipke; Stephan Rauthe; Grit Mutzbauer; Roman C. Brands; Harald Ebhardt; Alexander C. Kübler; Urs D.A. Müller-Richter