Stephanie Barbosa | Researchain

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Featured researches published by Stephanie Barbosa.

Journal of Medicinal Chemistry | 2008

Discovery of Brivanib Alaninate ((S)-((R)-1-(4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), A Novel Prodrug of Dual Vascular Endothelial Growth Factor Receptor-2 and Fibroblast Growth Factor Receptor-1 Kinase Inhibitor (BMS-540215)

Zhen-Wei Cai; Yongzheng Zhang; Robert M. Borzilleri; Ligang Qian; Stephanie Barbosa; Donna D. Wei; Xiaoping Zheng; Lawrence Wu; Junying Fan; Zhongping Shi; Barri Wautlet; Steve Mortillo; Robert Jeyaseelan; Daniel W. Kukral; Amrita Kamath; Punit Marathe; Celia D’Arienzo; George Derbin; Joel C. Barrish; Jeffrey A. Robl; John T. Hunt; Louis J. Lombardo; Joseph Fargnoli; Rajeev S. Bhide

A series of amino acid ester prodrugs of the dual VEGFR-2/FGFR-1 kinase inhibitor 1 (BMS-540215) was prepared in an effort to improve the aqueous solubility and oral bioavailability of the parent compound. These prodrugs were evaluated for their ability to liberate parent drug 1 in in vitro and in vivo systems. The l-alanine prodrug 8 (also known as brivanib alaninate/BMS-582664) was selected as a development candidate and is presently in phase II clinical trials.

Archive | 2003

Novel inhibitors of kinases

Rajeev S. Bhide; Zhen-Wei Cai; Ligang Qian; Stephanie Barbosa

Archive | 2003

Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders

Mark E. Salvati; Stephanie Barbosa; Zhong Chen; John T. Hunt

Archive | 2003

Pyrrolo[2,1-f][1,2,4]triazine inhibitors of kinases

Rajeev S. Bhide; Zhen-Wei Cai; Ligang Qian; Stephanie Barbosa

Archive | 2003

Process for preparing certain pyrrolotriazine compounds

Rajeev S. Bhide; Junying Fan; Luca Parlanti; Stephanie Barbosa; Ligang Qian; Zhen-Wei Cai; Francis S. Gibson

Archive | 2005

Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors

Gerard Crispino; Stephanie Barbosa; Junying Fan; Zhen-Wei Cai

Bioorganic & Medicinal Chemistry Letters | 2006

Pyrrolopyridazine MEK inhibitors

Zhong Chen; Soong-Hoon Kim; Stephanie Barbosa; Tram Huynh; David R. Tortolani; Kenneth J. Leavitt; Donna D. Wei; Veeraswamy Manne; Carolyn S. Ricca; Johnni Gullo-Brown; Michael A. Poss; Wayne Vaccaro; Mark E. Salvati

Archive | 2009

Inhibitors of kinases

Rajeev S. Bhide; Zhen-Wei Cai; Ligang Qian; Stephanie Barbosa; Louis J. Lombardo; Jeffrey A. Robl

Journal of Medicinal Chemistry | 2015

Erratum: N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent(Journal of Medicinal Chemistry (2004) 47 (1719-1728) DOI: 10.1021/jm0305568)

Raj N. Misra; Hai Yun Xiao; Kyoung S. Kim; Songfeng Lu; Wen Ching Han; Stephanie Barbosa; John T. Hunt; David B. Rawlins; Weifang Shan; Syed Z. Ahmed; Ligang Qian; Bang Chi Chen; Rulin Zhao; Mark S. Bednarz; Kristen A. Kellar; Janet G. Mulheron; Roberta Batorsky; Urvashi V. Roongta; Amrita Kamath; Punit Marathe; Sunanda A. Ranadive; John S. Sack; John S. Tokarski; Nikola P. Pavletich; Francis Y. Lee; Kevin R. Webster; S. David Kimball

Archive | 2003