Stephanie Springer | Researchain

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Featured researches published by Stephanie Springer.

Bioorganic & Medicinal Chemistry Letters | 2008

Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.

James W. Janetka; Lynsie Almeida; Susan Ashwell; Patrick Brassil; Kevin Daly; Chun Deng; Thomas Gero; Roberta Glynn; Candice Horn; Stephanos Ioannidis; Paul Lyne; Nicholas John Newcombe; Vibha Oza; Martin Pass; Stephanie Springer; Mei Su; Dorin Toader; Melissa Vasbinder; Dingwei Yu; Yan Yu; Sonya Zabludoff

Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1.

Archive | 2004

Substitute thiophenes and uses thereof

Susan Ashwell; Thomas Gero; Stephanos Ioannidis; James W. Janetka; Paul Lyne; Vibha Oza; Stephanie Springer; Mei Su; Dingwei Yu

Molecular Cancer Therapeutics | 2007

Structure activity and structure property relationships of a novel series of potent inhibitors of Checkpoint kinases

Lynsie Almeida; Susan Ashwell; David Ayres; Patrick Brassil; Kevin Daly; Chun Deng; Thomas Gero; Roberta Glynn; Candice Horn; Stephanos Ioannidis; James W. Janetka; Paul Lyne; Vibha Oza; Stephanie Springer; Mei Su; Dorin Toader; Melissa Vasbinder; Dingwei Yu; Yan Yu; Sonya Zabludoff

Bioorganic & Medicinal Chemistry Letters | 2010

Corrigendum to Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors

Alessandro Boezio; Loren Berry; Brian K. Albrecht; David Bauer; Steven Bellon; Christiane Bode; April Chen; Deborah Choquette; Isabelle Dussault; Mei Fang; Satoko Hirai; Paula Kaplan-Lefkco; Jay Larrow; Min-Hwa Jasmine Lin; Julia Lohman; Michele Potashman; Yusheng Qu; Karen Rex; Michael Santostefano; Kavita Shah; Roman Shimanovich; Stephanie Springer; Yohannes Teffera; Yajing Yang; Yihong Zhang; Jean-Christophe Harmange

Bioorganic & Medicinal Chemistry Letters | 2009

Corrigendum to synthesis and activity of substituted carbamates as potentiators of the α4β2 nicotinic acetylcholine receptor

Stephanie Springer; Katrina S. Woodin; Virginia Berry; Alessandro Boezio; Lei Cao; Kristie Clarkin; Jean-Christophe Harmange; Markus Hierl; Johannes Knop; Annika B. Malmberg; Jeff S. McDermott; Hung Q. Nguyen; Daniel Waldon; Brian K. Albrecht

Archive | 2008

Fused heterocyclic derivatives and methods of use as c-met inhibitors

Brian K. Albrecht; David Bauer; Steven Bellon; Christiane Bode; Shon Booker; Alessandro Boezio; Deborah Choquette; Erin D'amico; Jean-Christophe Harmange; Satoko Hirai; Randall W. Hungate; Tae-Seong Kim; Richard T. Lewis; Longbin Liu; Julia Lohman; Mark H. Norman; Michelle Potashman; Aaron C. Siegmund; Stephanie Springer; Markian Stec; Ning Xi; Kevin Yang; Emily A. Peterson; Karina Romero; Katrina W. Copeland

Archive | 2008

Dérivés hétérocycliques réunis par fusion et procédés d'utilisation associés

Archive | 2007

Derives heterocycliques condenses utiles en tant que inhibiteurs du recepteur du facteur de croissance des hepatocytes

Brian K. Albrecht; David Bauer; Steven Bellon; Christiane Bode; Shon Booker; Alessandro Boezio; Deborah Choquette; Derin C. D'amico; Jean-Christophe Harmange; Satoko Hirai; Randall W. Hungate; Tae-Seong Kim; Richard T. Lewis; Longbin Liu; Julia Lohman; Mark H. Norman; Michele Potashman; Aaron C. Siegmund; Stephanie Springer; Markian Stec; Ning Xi; Kevin Yang

Archive | 2007