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Dive into the research topics where Stephen Charles Wilkie is active.

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Featured researches published by Stephen Charles Wilkie.


Biofutur | 1997

Glycopeptide antibiotic derivatives

Robin D. G. Cooper; Bret E. Huff; Thalia I. Nicas; John Thomas Indianapolis Quatroche; Michael J. Rodriguez; Nancy June Snyder; Michael A. Staszak; Richard Craig Thompson; Stephen Charles Wilkie; Mark J. Zweifel

The present invention provides glycopeptide antibiotic derivative compounds. These derivative compounds possess antibacterial activity aginst a wide variety of bacteria, including activity against vancomycin-resistant isolates. Methods of making and using these glycopeptide antibiotic derivative compounds are also provided.


The Journal of Antibiotics | 1996

Reductive Alkylation of Glycopeptide Antibiotics: Synthesis and Antibacterial Activity

Robin D. G. Cooper; Nancy June Snyder; Mark J. Zweifel; Michael A. Staszak; Stephen Charles Wilkie; Thalia I. Nicas; Deborah L. Mullen; Thomas F. Butler; Michael J. Rodriguez; Bret E. Huff; Richard Craig Thompson


Chemistry & Biology | 1997

Production of hybrid glycopeptide antibiotics in vitro and in Streptomyces toyocaensis.

Patricia J. Solenberg; Patti Matsushima; Douglas Richard Stack; Stephen Charles Wilkie; Richard Craig Thompson; Richard H. Baltz


Antimicrobial Agents and Chemotherapy | 1996

Semisynthetic glycopeptide antibiotics derived from LY264826 active against vancomycin-resistant enterococci.

Thalia I. Nicas; Deborah L. Mullen; Jane E. Flokowitsch; David A. Preston; Nancy June Snyder; Mark J. Zweifel; Stephen Charles Wilkie; Michael J. Rodriguez; Richard Craig Thompson; Robin D. G. Cooper


Archive | 2004

Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

Richard Craig Thompson; Stephen Charles Wilkie; Douglas Richard Stack; Eldon E. Vanmeter; Qing Shi; Thomas C. Britton; James E. Audia; Jon K. Reel; Thomas Edward Mabry; Bruce A. Dressman; Cynthia L. Cwi; Steven S. Henry; Stacey L. Mcdaniel; Russell D. Stucky; Warren J. Porter


Archive | 1999

Compounds for inhibiting beta-amyloid peptide release and/or its synthesis

Richard Craig Thompson; Stephen Charles Wilkie; Douglas Richard Stack; Eldon E. Vanmeter; Qing Shi; Thomas C. Britton; James E. Audia; Jon K. Reel; Thomas Edward Mabry; Bruce A. Dressman; Cynthia L. Cwi; Steven S. Henry; Stacey L. Mcdaniel; Russell D. Stucky; Warren J. Porter


Archive | 2002

Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

James E. Audia; Warren J. Porter; Richard Craig Thompson; Stephen Charles Wilkie; Douglas Richard Stack; Qing Shi


The Journal of Antibiotics | 1998

Novel Glycopeptide Antibiotics: N-Alkylated Derivatives Active Against Vancomycin-Resistant Enterococci

Michael J. Rodriguez; Nancy June Snyder; Mark J. Zweifel; Stephen Charles Wilkie; Douglas Richard Stack; Robin D. G. Cooper; Thalia I. Nicas; Deborah L. Mullen; Thomas F. Butler; Richard Craig Thompson


Archive | 1999

N1 modified glycopeptides

Richard Craig Thompson; Stephen Charles Wilkie


Archive | 1998

Alkylated antibiotic hexapeptides

Richard Craig Thompson; Stephen Charles Wilkie

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