Stephen D. Mills

Surgical Treatment of Coarctation of the Aorta in a Ten Week Old Infant: Report of a Case

Although most patients with coarctation of the aorta survive to early adult life, it has been adequately demonstrated that some patients die in infancy and early childhood as a result of their coarctation. In selected cases, then, operation is advisable at a very early age. Cardiac failure in a 10 week old infant necessitated operation at this age in the case reported.

The Hemolytic-Uremic Syndrome of Infancy

ness characterized by hemolytic aneznia, thrombocytopenia, and nephropathy, they referred to this clinical picture as the hemolyticuremic syndrome. At least 185 cases have now been reported in the world literature.’-8, 10-23. 25 Gianantonio and colleagues 8 from Buenos Aires, who encountered 58 cases, have noted that the syndrome can occur in epidemic form and suggest that it may have a viral origin. This report discusses three infants who were

Chemotherapy of the leukemic transformation of lymphosarcoma.

The chemotherapy of leukemic transformation of lymphosarcoma has been studied in seventeen children. Complete hematologic remission was obtained in 88 per cent treated with 6-mercaptopurine and prednisone. Maintenance therapy with 6-mercaptopurine was employed and the median duration of remission was 21 weeks. These results are comparable to those obtained in a series of children with acute lymphocytic leukemia in which the remission rate was 82 per cent and median duration of remissoin was 33 weeks with the same therapy.

Survival of patient with hemophilia and fracture of femur.

1)m’ocedures are carried out intentionally on hemophiliacs only on rare occasions. There is lack of agreement as to ti-ic best coum’se to follow’ in time managemmwnt of sumrgical l)roblemns in ti-ic hemuophiliac. Some writers state that sum’gical t t’eatment is contra-indicated undem’ all circumstances. ()thcrs advise against such treatment unless it is clearly evident that death-i w-ill ensue if it is not undertaken . Recent reports in the literature, how-ever, attest to the fact tlmat with proper m-i-ianagcmcnt ti-ic hemophilic patient can withstand considerable trauma and even extensive surgical procedures. Successful mid-timigim amuputations were reported by Crandon and associates and by Sci-iuster. Walker and Desmond

Purpuric manifestations occurring in measles in childhood

Summary Purpura as a complication of measles is not of common occurrence. Ten instances were found in a review of the pediatric case records of the Mayo Clinic for a period of thirty years, and one case is reported herein. Purpura may afford evidence of an underlying blood dyscrasia. Of eleven reported patients in whom purpuric manifestations followed measles, four were found to have thrombocytopenic purpura and two, leucemia. The remaining five patients showed little or no increase in the size of the liver, spleen, or lymph nodes. Only one of these had a definite thrombocytopenia with prolongation of the bleeding time. There were two deaths in the eleven cases reported. The outlook for the ultimate recovery of patients who exhibit purpuric manifestations following measles is good. However, one must be certain that such purpura is not an evidence of a blood dyscrasia or the accompaniment of a severe infection.