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Dive into the research topics where Stephen D. Taylor is active.

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Featured researches published by Stephen D. Taylor.


Journal of Chromatography A | 2000

Selective deuterium exchange during superheated heavy water chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry of sulfonamides.

Roger M. Smith; Orapin Chienthavorn; Shikha Saha; Ian D. Wilson; Brian Wright; Stephen D. Taylor

Superheated deuterium oxide has been investigated as an eluent for reversed-phase HPLC on a polystyrene-divinylbenzene column with UV, 1H NMR and MS detection using a series of sulfonamides as model compounds. In the course of these studies, a selective, specific and efficient deuteration of the methyl groups on a pyrimidine ring was observed during chromatography of certain of the sulfonamides. The potential of this methodology for producing deuterium-labelled compounds from substances bearing suitable substituents is considered. The utility of HPLC-NMR-MS as a means for studying on-column reactions is discussed.


Analytical Chemistry | 1999

Superheated heavy water as the eluent for HPLC-NMR and HPLC-NMR-MS of model drugs

Roger M. Smith; Orapin Chienthavorn; Ian D. Wilson; Brian Wright; Stephen D. Taylor


Journal of Agricultural and Food Chemistry | 2000

Application of directly coupled HPLC-NMR-MS/MS to the identification of metabolites of 5-trifluoromethylpyridone (2-hydroxy-5-trifluoromethylpyridine) in hydroponically grown plants.

Nigel J.C. Bailey; Paul Cooper; Stephen Thomas Hadfield; Eva M. Lenz; John C. Lindon; Jeremy K. Nicholson; Paul D. Stanley; Ian D. Wilson; Brian Wright; Stephen D. Taylor


Journal of Pharmaceutical and Biomedical Analysis | 2004

Superheated water chromatography-nuclear magnetic resonance spectroscopy and mass spectrometry of vitamins.

Orapin Chienthavorn; Roger M. Smith; Shikha Saha; Ian D. Wilson; Brian Wright; Stephen D. Taylor; Eva M. Lenz


Archive | 1995

Enantioselective preparation of pharmaceutically active sulfoxides by bioreduction

Daniel Graham; Robert Holt; Per Lennart Lindberg; Stephen D. Taylor


Archive | 2000

Short communication Selective deuterium exchange during superheated heavy water chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry of sulfonamides

Roger Smith; Orapin Chienthavorn; Shikha Saha; Ian D. Wilson; Brian Wright; Stephen D. Taylor


Archive | 1995

Enantioselective herstellung von pharmazeutisch aktiven sulfoxiden durch bioreduktion

Daniel Graham; Robert Holt; Per Lennart Lindberg; Stephen D. Taylor


Archive | 1995

Enantioselective herstellung von pharmazeutisch aktiven sulfoxiden durch bioreduktion Enantioselective production of pharmaceutically active sulfoxides by Bioreduction

Daniel Graham; Robert Holt; Per Lennart Lindberg; Stephen D. Taylor


Archive | 1995

Enantiosektive manufacture of pharmaceutically active sulfoxide by biooxidation

Robert Holt; Per Lennart Lindberg; Christopher David Reeve; Stephen D. Taylor


Archive | 1995

Enantiosektive herstellung pharmazeutisch aktiver sulfoxide durch biooxidation Enantiosektive manufacture pharmaceutically active sulfoxide by biooxidation

Robert Holt; Per Lennart Lindberg; Christopher David Reeve; Stephen D. Taylor

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Shikha Saha

Loughborough University

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