Stephen Markwell
Southern Illinois University School of Medicine
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Publication
Featured researches published by Stephen Markwell.
American Journal of Cardiology | 1990
George J. Taylor; Frank L. Mikell; H.Weston Moses; James T. Dove; Richard E. Katholi; Shezad A. Malik; Stephen Markwell; Cynthia Korsmeyer; Joel A. Schneider; Harry A. Wellons
This is a prospective study of 500 consecutive patients having coronary artery bypass surgery; mean hospital charge from time of surgery to discharge was +11,900 +/- 12,700. Multiple regression analysis was performed using preoperative variables and postoperative complications. No preoperative clinical feature was a significant predictor of higher average charge. Sternal wound infection (p = 0.0001), respiratory failure (p = 0.0001) and left ventricular failure (p = 0.017) were associated with higher average hospital charge. The absence of any complication predicted a lower average charge, and postoperative death (4.4 +/- 4.5 days after surgery) was also associated with lower average charge. A cost equation was developed: hospital charge equalled
Annals of Emergency Medicine | 2010
Myto Duong; Stephen Markwell; John Peter; Stephen J. Barenkamp
11,217 +
Medicine and Science in Sports and Exercise | 2009
Laura Q. Rogers; Patricia Hopkins-Price; Sandy Vicari; Richard Pamenter; Kerry S. Courneya; Stephen Markwell; Steven Verhulst; Karen Hoelzer; Catherine Naritoku; Linda Jones; Gary L. Dunnington; Victor Lanzotti; James Wynstra; Lisa Shah; Billie Edson; Ashleigh Graff; Michelle Lowy
41,559 of sternal wound infection, +
Oncogene | 2005
Sucharita Bandyopadhyay; Sudha K. Pai; Steven C. Gross; Shigeru Hirota; Sadahiro Hosobe; Taisei Tsukada; Kunio Miura; Ken Saito; Stephen Markwell; Ying Wang; Jodi Huggenvik; Mary E. Pauza; Megumi Iiizumi; Kounosuke Watabe
28,756 for respiratory failure, +
The Journal of Thoracic and Cardiovascular Surgery | 2012
Christina M. Vassileva; John Shabosky; Theresa M. Boley; Stephen Markwell; Stephen R. Hazelrigg
5,186 for left ventricular failure, -
Psycho-oncology | 2009
Laura Q. Rogers; Stephen Markwell; Steven Verhulst; Edward McAuley; Kerry S. Courneya
1,798 for no complication and -
Alzheimer Disease & Associated Disorders | 1996
Robert E. Becker; Jerry A. Colliver; Stephen Markwell; Pamela L. Moriearty; Latha Unni; Sandra Vicari
6,019 for death. Recognition of the influence of complications on charges suggests that low average charges can only be achieved by surgical programs with a low complication rate.
Cancer Epidemiology, Biomarkers & Prevention | 2009
Laura Q. Rogers; Patricia Hopkins-Price; Sandy Vicari; Stephen Markwell; Richard Pamenter; Kerry S. Courneya; Karen Hoelzer; Catherine Naritoku; Billie Edson; Linda Jones; Gary L. Dunnington; Steven Verhulst
STUDY OBJECTIVE Emergency department visits for skin and soft tissue infections are increasing with the discovery of community-acquired methicillin-resistant Staphylococcus aureus. Whether abscesses treated surgically also require antibiotics is controversial. There are no published pediatric randomized controlled trials evaluating the need for antibiotics in skin abscess management. We determine the benefits of antibiotics in surgically managed pediatric skin abscesses. METHODS This was a double-blind, randomized, controlled trial. Pediatric patients were randomized to receive 10 days of placebo or trimethoprim-sulfamethoxazole after incision and draining. Follow-up consisted of a visit/call at 10 to 14 days and a call at 90 days. Primary outcome was treatment failure at the 10-day follow-up. Secondary outcome was new lesion development at the 10- and 90-day follow-ups. Noninferiority of placebo relative to trimethoprim-sulfamethoxazole for primary and secondary outcomes was assessed. RESULTS One hundred sixty-one patients were enrolled, with 12 lost to follow-up. The failure rates were 5.3% (n=4/76) and 4.1% (n=3/73) in the placebo and antibiotic groups, respectively, yielding a difference of 1.2%, with a 1-sided 95% confidence interval (CI) (-infinity to 6.8%). Noninferiority was established with an equivalence threshold of 7%. New lesions occurred at the 10-day follow-up: 19 on placebo (26.4%) and 9 on antibiotics (12.9%), yielding a difference of 13.5%, with 95% 1-sided CI (-infinity to 24.3%). At the 3-month follow-up, 15 of 52 (28.8%) in the placebo group and 13 of 46 (28.3%) in the antibiotic group developed new lesions. The difference was 0.5%, with 95% 1-sided CI (-infinity to 15.6%). CONCLUSION Antibiotics are not required for pediatric skin abscess resolution. Antibiotics may help prevent new lesions in the short term, but further studies are required.
Circulation | 2013
Christina M. Vassileva; Gregory Mishkel; Christian McNeely; Theresa M. Boley; Stephen Markwell; Steven L. Scaife; Stephen R. Hazelrigg
PURPOSE Interventions to increase physical activity among breast cancer survivors are needed to improve health and quality of life and possibly to reduce the risk of disease recurrence and early mortality. Therefore, we report the feasibility and preliminary outcomes of a pilot randomized trial designed to increase physical activity in sedentary breast cancer survivors receiving hormone therapy. METHODS Forty-one sedentary women on estrogen receptor modulators or aromatase inhibitors for stage I, II, or IIIA breast cancer were randomly assigned to receive a 12-wk multidisciplinary physical activity behavior change intervention or usual care. RESULTS Recruitment was 34%, intervention adherence was 99%, and complete follow-up data were obtained on 93%. Most participants (93%) were white with mean age of 53 +/- 9 yr. Differences favoring the intervention group were noted for accelerometer physical activity counts (mean difference = 72,103; 95% confidence interval (CI) = 25,383-119,000; effect size (d) = 1.02; P = 0.004), aerobic fitness (mean difference = 2.9; 95% CI = -0.1 to 5.8; d = 0.64; P = 0.058), back/leg muscle strength (mean difference = 12.3; 95% CI = 0.4-15.9; d = 0.81; P = 0.017), waist-to-hip ratio (mean difference = -0.05; 95% CI = -0.01 to -0.08; d = -0.77; P = 0.018), and social well-being (mean difference = 2.0; 95% CI = 0.3-3.8; d = 0.76; P = 0.03). However, the intervention group also reported a greater increase in joint stiffness (mean difference = 1.1; 95% CI = 0.1-2.2; d = 0.70; P = 0.04). CONCLUSIONS A behavior change intervention for breast cancer survivors based on the social cognitive theory is feasible and results in potentially meaningful improvements in physical activity and selected health outcomes. Confirmation in a larger study is warranted.
Clinical Neuropsychologist | 2007
Ronald F. Zec; Nicole R. Burkett; Stephen Markwell; Deb L. Larsen
Fatty acid synthase (FAS), a key enzyme of the fatty acid biosynthetic pathway, has been shown to be overexpressed in various types of human cancer and is, therefore, considered to be an attractive target for anticancer therapy. However, the exact mechanism of overexpression of the FAS gene in tumor cells is not well understood. In this report, we demonstrate that the expression of the tumor suppressor gene PTEN has a significant inverse correlation with FAS expression in the case of prostate cancer in the clinical setting, and inhibition of the PTEN gene leads to the overexpression of FAS in vitro. We also found that the combination of the expression status of these two genes is a better prognostic marker than either gene alone. Furthermore, our results indicate that the specific inhibition of FAS gene by siRNA leads to apoptosis of prostate tumor cells, and inhibition of PI 3-kinase pathway synergizes with FAS siRNA to enhance tumor cell death. These results provide a strong rationale for exploring the therapeutic use of an inhibitor of the PTEN signaling pathway in conjunction with the FAS siRNA to inhibit prostate tumor growth.