Stephen P. Keen | Researchain

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Featured researches published by Stephen P. Keen.

Tetrahedron Letters | 2000

Studies on total synthesis of cylindrospermopsin: new constructions of uracils from α,β-unsaturated esters

Stephen P. Keen; Steven M. Weinreb

Abstract Two different routes have been developed to prepare uracils related to that found in the marine hepatotoxin cylindrospermopsin starting from α,β-unsaturated esters.

Journal of Organic Chemistry | 2006

Practical Asymmetric Synthesis of a γ-Secretase Inhibitor Exploiting Substrate-Controlled Intramolecular Nitrile Oxide−Olefin Cycloaddition

Jeremy P. Scott; Steven F. Oliver; Karel M. J. Brands; Sarah E. Brewer; Antony J. Davies; Andrew D. Gibb; David Hands; Stephen P. Keen; Faye J. Sheen; Robert A. Reamer; Robert Darrin Wilson; Ulf-H. Dolling

Journal of the American Chemical Society | 2002

Stereoselective total syntheses and reassignment of stereochemistry of the freshwater cyanobacterial hepatotoxins cylindrospermopsin and 7-epicylindrospermopsin.

Geoffrey R. Heintzelman; Wen-kui Fang; Stephen P. Keen; Grier A. Wallace; Steven M. Weinreb

Journal of the American Chemical Society | 2001

Stereoselective total synthesis of the cyanobacterial hepatotoxin 7-epicylindrospermopsin: revision of the stereochemistry of cylindrospermopsin.

Geoffrey R. Heintzelman; Wen-kui Fang; Stephen P. Keen; and Grier A. Wallace; Steven M. Weinreb

Journal of Organic Chemistry | 2005

Practical Asymmetric Synthesis of a Non-Peptidic αvβ3 Antagonist

Stephen P. Keen; Cameron J. Cowden; Brian Bishop; Karel M. J. Brands; Antony J. Davies; Ulf H. Dolling; David R. Lieberman; Gavin W. Stewart

Organic Process Research & Development | 2011

Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor

Debra J. Wallace; Carl A. Baxter; Karel J. M. Brands; Nadine Bremeyer; Sarah E. Brewer; Richard Desmond; Khateeta M. Emerson; Jennifer R. Foley; Paul Fernandez; Weifeng Hu; Stephen P. Keen; Peter R. Mullens; Daniel J. Muzzio; Peter Sajonz; Lushi Tan; Robert Darrin Wilson; George Zhou; Guoyue Zhou

Journal of Organic Chemistry | 1998

Studies on the Synthesis of Pinnaic Acid and Halichlorine. Stereoselective Preparation of a (Z)-δ-Chloro-γ,δ-unsaturated-β-keto Phosphonate as a Side Chain Synthon

Stephen P. Keen; Steven M. Weinreb

Organic Process Research & Development | 2010

Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor

Gavin W. Stewart; Karel M. J. Brands; Sarah E. Brewer; Cameron J. Cowden; Antony J. Davies; John S. Edwards; Andrew W. Gibson; Simon E. Hamilton; Jason D. Katz; Stephen P. Keen; Peter R. Mullens; Jeremy P. Scott; Debra J. Wallace; Christopher Wise

Organic Process Research & Development | 2012

Multikilogram-Scale Synthesis of a Chiral Cyclopropanol and an Investigation of the Safe Use of Lithium Acetylide–Ethylene Diamine Complex

Ephraim M. Bassan; Carl A. Baxter; Gregory L. Beutner; Khateeta M. Emerson; Fred J. Fleitz; Simon Johnson; Stephen P. Keen; Mary M. Kim; Jeffrey T. Kuethe; William R. Leonard; Peter R. Mullens; Daniel J. Muzzio; Christopher Roberge; Nobuyoshi Yasuda

Organic Process Research & Development | 2014

Enantioselective Synthesis of a Highly Substituted Tetrahydrofluorene Derivative as a Potent and Selective Estrogen Receptor Beta Agonist

Matthew L. Maddess; Jeremy P. Scott; Anthony Alorati; Carl A. Baxter; Nadine Bremeyer; Sarah E. Brewer; Kevin R. Campos; Ed Cleator; Alejandro Dieguez-Vazquez; Andrew D. Gibb; Andrew W. Gibson; Melissa Howard; Stephen P. Keen; Artis Klapars; Jaemoon Lee; Jing Li; Joseph J. Lynch; Peter R. Mullens; Debra J. Wallace; Robert Darrin Wilson

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