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Publication
Featured researches published by Stephen Price.
Bioorganic & Medicinal Chemistry Letters | 2009
Shirley A. Brunton; John H.A. Stibbard; Lee L. Rubin; Oivin M. Guicherit; Lawrence I. Kruse; Stephen Price; Raffaella Di Lucrezia; Colin H. MacKinnon; Alaric Avery; Yvonne Park; Danielle Buxton; Edward Andrew Boyd
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to substitution on the 4-amino group, and SAR for the 3-chlorobenzothiophene group is highly specific. Preliminary SAR studies of the biaryl substituent led to a picomolar compound with in vivo activity.
Archive | 2002
Anthony David Baxter; Edward Andrew Boyd; Maria Frank-Kamenetsky; Oivin M. Guicherit; Jeffery A. Porter; Stephen Price; Lee L. Rubin; John H.A. Stibbard
Archive | 2000
Anthony David Baxter; Edward Andrew Boyd; Oivin M. Guicherit; Jeffrey Porter; Stephen Price; Lee L. Rubin
Archive | 2002
Edward Andrew Boyd; Oivin M. Guicherit; Stephen Price; Lee L. Rubin
Archive | 2002
Edward Andrew Boyd; Oivin M. Guicherit; Stephen Price; Lee L. Rubin
Archive | 2002
Anthony David Baxter; Edward Andrew Boyd; Maria Frank-Kamenetsky; Jeffery A. Porter; Stephen Price; Lee L. Rubin; John H.A. Stibbard
Archive | 2002
Lee L. Rubin; Oivin M. Guicherit; Stephen Price; Edward Andrew Boyd
Archive | 2002
Lee L. Rubin; Oivin M. Guicherit; Stephen Price; Edward Andrew Boyd
Archive | 2001
Anthony David Baxter; Edward Andrew Boyd; Maria Frank-Kamenetsky; Oivin M. Guicherit; Jeffrey Porter; Stephen Price; Lee E. Rubin
Archive | 2001
David Anthony Baxter; Edward Andrew Boyd; Maria Frank-Kamenetsky; M. Oivin Guicherit; Jeffrey Porter; Stephen Price; E. Lee Rubin
