Steve R. Turner
Pfizer
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Publication
Featured researches published by Steve R. Turner.
Bioorganic & Medicinal Chemistry Letters | 1998
Musiri N. Janakiraman; Keith D. Watenpaugh; Paul K. Tomich; Chong Kt; Steve R. Turner; Ruben Tommasi; Suvit Thaisrivongs; Joseph Walter Strohbach
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-related sulfonamide group. Selected bis-sulfonamide dihydropyrone analogues display high HIV protease inhibitory activity.
ACS Medicinal Chemistry Letters | 2010
Chris P. Carron; John I. Trujillo; Kirk L. Olson; Wei Huang; Bruce C. Hamper; Tom Dice; Bradley E. Neal; Matthew James Pelc; Jacqueline E. Day; Douglas C. Rohrer; James R. Kiefer; Joseph B. Moon; Barbara Ann Schweitzer; Tanisha D. Blake; Steve R. Turner; Rhonda S. Woerndle; Brenda L. Case; Christine P. Bono; Vickie M. Dilworth; Christie L. Funckes-Shippy; Becky Hood; Gina M. Jerome; Christine M. Kornmeier; Melissa R. Radabaugh; Melanie L. Williams; Michael S. Davies; Craig D. Wegner; Dean Welsch; William M. Abraham; Chad J. Warren
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In this letter, we report the discovery of an orally potent and selective inhibitor of HPGDS that reduces the antigen-induced response in allergic sheep.
Journal of Medicinal Chemistry | 1998
Steve R. Turner; Joseph Walter Strohbach; Ruben Tommasi; Paul A. Aristoff; Paul D. Johnson; Harvey I. Skulnick; Lester A. Dolak; Eric P. Seest; Paul K. Tomich; Michael John Bohanon; Miao-Miao Horng; Janet C. Lynn; Chong Kt; Roger R. Hinshaw; Keith D. Watenpaugh; Musiri N. Janakiraman; Suvit Thaisrivongs
Journal of Medicinal Chemistry | 1986
Suvit Thaisrivongs; Donald T. Pals; Warren M. Kati; Steve R. Turner; Lisa M. Thomasco; William Watt
Journal of Medicinal Chemistry | 1996
Suvit Thaisrivongs; Donna Lee Romero; Ruben A Tommasi; Musiri N. Janakiraman; Joseph Walter Strohbach; Steve R. Turner; Carolyn Biles; Raymond R. Morge; Paul D. Johnson; Paul Adrian Aristoff; Paul K. Tomich; Janet C. Lynn; Miao Miao Horng; Kong Teck Chong; Roger R. Hinshaw; W. Jeffrey Howe; Barry C. Finzel; Keith D. Watenpaugh
Journal of Medicinal Chemistry | 1988
Suvit Thaisrivongs; Donald T. Pals; Steve R. Turner; Lisa T. Kroll
Journal of Medicinal Chemistry | 1987
Suvit Thaisrivongs; Donald T. Pals; Lisa T. Kroll; Steve R. Turner; Fu Son Han
Journal of Medicinal Chemistry | 1987
Suvit Thaisrivongs; Heinrich J. Schostarez; Donald T. Pals; Steve R. Turner
Journal of Medicinal Chemistry | 1985
Suvit Thaisrivongs; Donald T. Pals; Warren M. Kati; Steve R. Turner; Lisa M. Thomasco
Journal of Medicinal Chemistry | 1991
Suvit Thaisrivongs; Alfredo G. Tomasselli; Joseph B. Moon; John O. Hui; Thomas J. McQuade; Steve R. Turner; Joseph Walter Strohbach; W. Jeffrey Howe; Robert L. Heinrikson