Steven Einstein

A PROSPECTIVE, SYSTEMATIC LITERATURE REVIEW AND META-ANALYSES TO EVALUATE GLOBAL AND REGIONAL BRAIN VOLUMES BY STRUCTURAL MRI AS BIOMARKERS OF ALZHEIMER'S DISEASE (AD) PROGRESSION

and MMSE was found in the occipital lobes for the combined AD+MCI+HC (Pearson 0.82, p1⁄40.0465) and AD (Pearson 0.99, p1⁄40.01) groups. Conclusions:Based on relatively small number of studies, no apparent relationship between change on brain amyloid burden and cognition in AD was found. In contrast, the negative correlation seen in MCI suggests that PiB PET changes may be a useful biomarker in earlier disease phases. The significant finding in the correlation between changes in amyloid deposition in the occipital lobe and MMSE warrants further study. Limitation included the paucity of studies having longitudinal data on both brain amyloid burden and clinical measures and heterogeneity amongst studies.

Discordance for hippocampal atrophy and amyloid burden in amnestic mild cognitive impairment may identify distinct subgroups of patients

P3-081 CHANGES IN THE VETERANS AFFAIRS SAINT LOUIS UNIVERSITY MENTAL STATUS (SLUMS) EXAM SCORES OVER 7.5 YEARS’ FOLLOW-UP AND RELATED OUTCOMES: THE INFLUENCE OF REVERSIBLE COGNITIVE IMPAIRMENTAND CORRECTION OF SENSORY LOSS Dulce Cruz-Oliver, TheodoreMalmstrom, Nina Tumosa, JohnMorley, 1 Saint Louis University School of Medicine, St. Louis, Missouri, United States; Geriatric Research Education and Clinical Centers, St Louis VAMC, Jefferson Barracks, St. Louis, Missouri, United States; Saint Louis University Medical Center, St. Louis, Missouri, United States.

POOLED AMYLOID PET BASELINE DATA FROM THE BAPINEUZUMAB IV PHASE III TRIALS

mL (n1⁄4516), 5.86 (1.10) mL (n1⁄4518) and 50.56 (22.89) mL (n1⁄4517), respectively. The left hippocampus volume (LHV) was 0.117 mL (95% CI: 0.088-0.145) smaller than the right hippocampus volume (RHV) with volumes of 2.87 (0.56) mL (n1⁄4518) and 2.99 (0.59) mL (n1⁄4518), respectively. Mild AD subjects (MMSE 21) had a larger brain volume (95% CI: 16.392-51.390) and LHV (95% CI: 0.012-0.206) than moderate AD patients (MMSE 20). In contrast significant differences were not observed between mild and moderate AD subjects in the RHVand total hippocampus volume or ventricular volume. Whole brain and ventricles volume were not impacted by APOE4 status of subjects whereas a difference was found for LHV (95% CI:0.074-0.278), RHV (95% CI:0.064-0.283) and total (95% CI:0.148-0.553) hippocampus volume with APOE4-carriers presenting with more atrophied structures. Conclusions: These data from a partial sample of EPOCH trial participants showed differences in whole brain atrophy stage between mild and moderate AD patients and a higher hippocampal atrophy in APOE4-carriers They also suggest that the left hippocampus is more vulnerable to atrophy than the right hippocampus. A comparison of our study brain parameters to ADNI data will also be presented.

The impact of gradient field distortion on the calculation of brain atrophy in Alzheimer's disease, derived from volumetric MRI using the boundary shift integral

P1-335 THE IMPACT OF GRADIENT FIELD DISTORTION ON THE CALCULATION OF BRAIN ATROPHY IN ALZHEIMER’S DISEASE, DERIVED FROM VOLUMETRIC MRI USING THE BOUNDARY SHIFT INTEGRAL Steven Einstein, Sylvain Bouix, Casper Nielsen, Shona Clegg, Andrea Les, Howard Simon, Derek Hill, Richard Margolin, Reisa Sperling, Nick Fox, Enchi Liu, Gerald Novak, Janssen Alzheimer Immunotherapy, South San Francisco, California, United States; Brigham and Women’s Hospital, Boston, Massachusetts, United States; University College London, London, United Kingdom; University College London, London, United Kingdom; IXICO Ltd, London, United Kingdom; Synarc, Newark, California, United States; IXICO Ltd., London, United Kingdom; Brigham and Women’s Hospital, Boston, Massachusetts, United States; University College London, London, United Kingdom. Contact e-mail: seinstei@janimm.com