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Dive into the research topics where Steven H. Hinrichs is active.

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Featured researches published by Steven H. Hinrichs.


Molecular Microbiology | 2008

Staphylococcus aureus primase has higher initiation specificity, interacts with single-stranded DNA stronger, but is less stimulated by its helicase than Escherichia coli primase

Scott A. Koepsell; Marilynn A. Larson; Christopher A. Frey; Steven H. Hinrichs; Mark A. Griep

The study of primases from model organisms such as Escherichia coli, phage T7 and phage T4 has demonstrated the essential nature of primase function, which is to generate de novo RNA polymers to prime DNA polymerase. However, little is known about the function of primases from other eubacteria. Their overall low primary sequence homology may result in functional differences. To help understand which primase functions were conserved, primase and its replication partner helicase from the pathogenic Gram‐positive bacteria Staphylococcus aureus were compared in detail with that of E. coli primase and helicase. The conserved properties were to primer initiation and elongation and included slow kinetics, low fidelity and poor sugar specificity. The significant differences included S. aureus primase having sixfold higher kinetic affinity for its template than E. coli primase under equivalent conditions. This naturally higher activity was balanced by its fourfold lower stimulation by its replication fork helicase compared with E. coli primase. The most significant difference between the two primases was that S. aureus helicase stimulation did not broaden the S. aureus primase initiation specificity, which has important biological implications.


Medical Mycology | 2002

Utilization of the internal transcribed spacer regions as molecular targets to detect and identify human fungal pathogens

Peter C. Iwen; Steven H. Hinrichs; Mark E. Rupp


Archive | 2000

Materials and methods for molecular detection of clinically relevant pathogenic fungal species

Peter Iwen; Steven H. Hinrichs; Travis Henry


Carcinogenesis | 1994

Effect of catechol and ethanol with and without methylamylnitrosamine on esophageal carcinogenesis in the rat

Sidney S. Mirvish; Dennis D. Weisenburger; Steven H. Hinrichs; Jeannetta G. Nickols; Connie Hinman


Analytical Biochemistry | 2004

Thermally denaturing high-performance liquid chromatography analysis of primase activity

Scott A. Koepsell; Dhundy Bastola; Steven H. Hinrichs; Mark A. Griep


Archive | 1994

Methods for inhibiting transcription of the cyclic AMP responsive element binding protein and the activating transcription factor 1

Steven H. Hinrichs; Dana Jo Orten


BIOCOMP | 2007

Use of Average Mutual Information based Species Signature for Fungal and Mycobacterial Differentiation.

Khalid Sayood; Dhundy Bastola; Peter Iwen; Steven H. Hinrichs


Archive | 2013

Serratia marcescens Isolated from Enterobacter cloacae and in an IncL/M Plasmid, pNE1280, 4401Is Encoded within a Truncated Tn

Steven H. Hinrichs; Mark E. Rupp; Paul D. Fey Thapa; Dhundy Bastola; Laurina O. Williams; A. Bryant; Trevor C. Van Schooneveld


Archive | 2011

RAIphy: Phylogenetic classification ofmetagenomics samples using iterative refinementof relative abundance index profiles

Ozkan Ufuk Nalbantoglu; Samuel F Way; Steven H. Hinrichs; Khalid Sayood


Archive | 2010

Leukemia With "Hodgkin's Transformation" Origin of the Hodgkin/Reed-Sternberg Cells in Chronic Lymphocytic

Wing C. Chan; Toshiyuki Ohno; Bassam N. Smir; Dennis D. Weisenburger; Randy D. Gascoyne; Steven H. Hinrichs

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Mark A. Griep

University of Nebraska–Lincoln

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Dhundy Bastola

University of Nebraska Omaha

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Khalid Sayood

University of Nebraska–Lincoln

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Scott A. Koepsell

University of Nebraska Medical Center

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Dennis D. Weisenburger

City of Hope National Medical Center

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Mark E. Rupp

Nebraska Medical Center

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Peter Iwen

University of Nebraska–Lincoln

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Bassam N. Smir

University of Texas Health Science Center at San Antonio

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Christopher A. Frey

University of Nebraska–Lincoln

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Connie Hinman

University of Nebraska Medical Center

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