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Steven J. Kline

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Tetrahedron Letters | 1988

Synthesis of a novel hexadentate chelating agent based on8-hydroxyquinoline

William D. Shrader; Joseph E. Celebuski; Steven J. Kline; David K. Johnson

Abstract A new hexadentate chelator was synthesized by the functionalization of 8-hydroxyquinoline to its 2-carboxy-N-hydroxysuccinimidyl ester and subsequent condensation with tris(2-aminoethyl)amine to givetris-N-(2-aminoethyl-[8-hydroxyquinoline-2-carboxamido])amine. This molecule is a siderophore analog with a non-naturally occurring binding unit comprising a combination of both oxygen and nitrogen donor atoms.

Archive | 1988

Bifunctional chelating agents

David K. Johnson; Steven J. Kline

Journal of Medicinal Chemistry | 1989

Synthesis of novel bifunctional chelators and their use in preparing monoclonal antibody conjugates for tumor targeting

David A. Westerberg; Patrick L. Carney; Patrick E. Rogers; Steven J. Kline; David K. Johnson

Bioconjugate Chemistry | 1991

Carboxymethyl-substituted bifunctional chelators: preparation of aryl isothiocyanate derivatives of 3-(carboxymethyl)-3-azapentanedioic acid, 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic++ + acid, and 1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid for use as protein labels.

Steven J. Kline; David A. Betebenner; David K. Johnson

Archive | 1987

8-hydroxyquinoline chelating agents

David K. Johnson; Steven J. Kline

Archive | 1991

Metal containing 8-hydroxyquinoline chelating agents

David K. Johnson; Steven J. Kline

Archive | 1988

Multidentate chelators based on the 8-hydroxyquinoline unit

David K. Johnson; Steven J. Kline

Archive | 1988

Bifunktionelle chelatbildende Agenzien. Bifunctional chelating agents.

David K. Johnson; Steven J. Kline

Archive | 1988

Un metodo para quelar un ion de metal.

David K. Johnson; Steven J. Kline

Archive | 1988

Multidentate chelating agent consisting of 8-hydroxyquinoline unit

David K. Johnson; Steven J. Kline

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David K. Johnson

University of Kansas

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Joseph E. Celebuski

University of Michigan

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William D. Shrader

California Institute of Technology

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