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Dive into the research topics where Steven J. Palazzo is active.

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Featured researches published by Steven J. Palazzo.


Respiratory Care | 2012

Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) as a Diagnostic Marker of Ventilator-Associated Pneumonia

Steven J. Palazzo; Terri Simpson; Jillian Simmons; Lynn M. Schnapp

OBJECTIVE: To determine the utility of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) samples from patients who underwent bronchoscopy for a clinical suspicion of ventilator-associated pneumonia (VAP), to categorize patients as VAP positive and VAP negative, when compared to quantitative culture results of BALF. METHODS: Observational study conducted on admitted patients in the trauma-surgical, medical-cardiac, burn, and neurosurgical ICUs of Harborview Medical Center between March 2009 and May 2010. BALF and EBC samples were obtained from 45 patients with clinically suspected VAP. Bronchoscopy was performed on the day of clinically suspected VAP. sTREM-1 levels in EBC and BAL fluid were measured using quantikine human TREM-1 immunoassay. VAP was diagnosed by quantitative cultures of BALF. RESULTS: The concentrations of sTREM-1 in BALF and EBC did not correlate with VAP status. sTREM-1 levels did not discriminate VAP positive from VAP negative patients, when compared to quantitative cultures of BALF as the gold standard. Using a cutoff value of 204 pg/mL for BALF sTREM-1 levels resulted in a sensitivity of 79% and a specificity of 23%. A cutoff value of 10 pg/mL for EBC sTREM-1 levels resulted in a sensitivity of 42% and a specificity of 50%. CONCLUSIONS: EBC and BALF sTREM-1 levels did not effectively categorize patients as VAP positive or VAP negative when using direct bronchoscopic quantitative culture samples as the comparison standard.


PLOS ONE | 2013

Proteomic profiling of bronchoalveolar lavage fluid in critically ill patients with ventilator-associated pneumonia.

Elizabeth V. Nguyen; Sina A. Gharib; Steven J. Palazzo; Yu Hua Chow; David R. Goodlett; Lynn M. Schnapp

Rationale Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to increased morbidity and mortality. Identifying protein profiles specific to VAP in bronchoalveolar lavage fluid (BALF) may aid in earlier diagnosis, elucidate mechanisms of disease, and identify putative targets for therapeutic intervention. Methods BALF was obtained from 5 normal subjects and 30 ALI patients: 14 with VAP (VAP+) and 16 without VAP (VAP–). Each sample underwent shotgun proteomic analysis based on tandem mass spectrometry. Differentially expressed proteins between the groups were identified using statistical methods based on spectral counting. Mechanisms of disease were explored using functional annotation and protein interaction network analysis. Supervised classification algorithms were implemented to discover a proteomic classifier for identifying critically ill patients with VAP. Results ALI patients had distinct BALF proteomic profiles compared to normal controls. Within the ALI group, we identified 76 differentially expressed proteins between VAP+ and VAP–. Functional analysis of these proteins suggested activation of pro-inflammatory pathways during VAP. We identified and validated a limited proteomic signature that discriminated VAP+ from VAP– patients comprised of three proteins: S100A8, lactotransferrin (LTF), and actinin 1 (ACTN1). Conclusions Combining proteomic with computational analyses is a powerful approach to study the BALF proteome during lung injury and development of VAP. This integrative methodology is a promising strategy to differentiate clinically relevant subsets of ALI patients, including those suffering from VAP.


Dimensions of Critical Care Nursing | 2012

Triggering receptor expressed on myeloid cells type 1 as a potential therapeutic target in sepsis.

Steven J. Palazzo; Terri Simpson; Lynn M. Schnapp

Excessive and unregulated inflammation contributes to multiorgan failure and death in sepsis. Triggering receptor expressed on myeloid cells type 1(TREM-1) is expressed on neutrophils and monocytes and is upregulated in the presence of bacterial pathogens. Engagement of TREM-1 results in increased expression of proinflammatory chemokines and cytokines and amplifies the inflammatory response. In this article, we will review the structure and signaling pathway of TREM-1 and review the role of TREM-1 and soluble TREM-1 in the inflammatory response during sepsis. Based on these studies, modulation of the TREM-1 signaling pathway has been suggested as a potential therapeutic strategy for the treatment of sepsis, to dampen the inflammatory response without interrupting the ability of the host to clear pathogens. This basic science research may someday lead to other treatments for sepsis and other diseases.


Public Health Nursing | 2017

High School CPR/AED Training in Washington State.

Gail Salvatierra; Steven J. Palazzo; Allison Emery

Objective: Describe the rates of CPR/AED training in high schools in the state of Washington after passage of legislation mandating CPR/AED training. Design and Sample: A web‐based survey was sent to administrators at 660 public and private high schools in the state of Washington. Results and Conclusions: The survey was completed by 148 schools (22%); 64% reported providing CPR training and 54% provided AED training. Reported barriers to implementation included instructor availability, cost, and a lack of equipment. Descriptive statistics were used to describe the sample characteristics and implementation rates. Mandates without resources and support do not ensure implementation of CPR/AED training in high schools. Full public health benefits of a CPR mandate will not be realized until barriers to implementation are identified and eliminated through use of available, accessible public health resources.


Nursing Outlook | 2017

Diversity dynamics: The experience of male Robert Wood Johnson Foundation nurse faculty scholars

Abraham A. Brody; Jason E. Farley; Gordon Lee Gillespie; Ronald L. Hickman; Eric A. Hodges; Courtney Lyder; Steven J. Palazzo; Todd M. Ruppar; Martin Schiavenato; Daniel J. Pesut

BACKGROUND Managing diversity dynamics in academic or clinical settings for men in nursing has unique challenges resulting from their minority status within the profession. PURPOSE The purpose of this study was to share challenges and lessons learned identified by male scholars in the Robert Wood Johnson Foundation Nurse Faculty Scholars program and suggest strategies for creating positive organizations promoting inclusive excellence. METHODS Multiple strategies including informal mentored discussions and peer-to-peer dialogue throughout the program, formal online surveys of scholars and National Advisory Committee members, and review of scholar progress reports were analyzed as part of the comprehensive evaluation plan of the program. DISCUSSION Diversity dynamic issues include concerns with negative stereotyping, microaggression, gender intelligence, and differences in communication and leadership styles. CONCLUSION Male nurse faculty scholars report experiencing both opportunities and challenges residing in a predominately female profession. This article attempts to raise awareness and suggest strategies to manage diversity dynamics in service of promoting the development of a culture of health that values diversity and inclusive excellence for both men and women in academic, research, and practice contexts.


Heart & Lung | 2011

Biomarkers for ventilator-associated pneumonia: review of the literature.

Steven J. Palazzo; Terri Simpson; Lynn M. Schnapp


Nursing education perspectives | 2016

Continuous Student Feedback: Your Voice Counts.

Steven J. Palazzo; Carrie Westmoreland Miller; Gail Salvatierra


Archive | 2017

Nursing Academic Leaders: A Tale of two Journeys

Omar Ali; Steven J. Palazzo; Jeffrey A. Willey


Journal of Adolescent Health | 2017

Teen Take Heart: A Pilot Intervention to Improve High School Students' Behavioral Intentions to Engage in Physical Activity and Better Nutrition

Steven J. Palazzo


44th Biennial Convention (28 October - 01 November 2017) | 2017

A Way Toward Ensuring a Relevant Undergraduate Curriculum: BSN Curriculum Assessment Plan

Steven J. Palazzo; Nancy C. Sharts-Hopko; Lynnette Leeseberg Stamler

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Terri Simpson

University of Washington

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Gail Salvatierra

California State University San Marcos

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Anne Hirsch

University of Portland

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Courtney Lyder

University of California

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