Stinabritt Nilsson
AstraZeneca
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Publication
Featured researches published by Stinabritt Nilsson.
Bioorganic & Medicinal Chemistry Letters | 2014
Karl Edman; Ragnhild Ahlgren; Malena Bengtsson; Håkan Bladh; Stefan Bäckström; Jan Dahmén; Krister Henriksson; Per Hillertz; Vijakumar Hulikal; Anders Jerre; Liz Kinchin; Charlotte Kåse; Matti Lepistö; Irene Mile; Stinabritt Nilsson; Amir Smailagic; John D. Taylor; Ann Tjörnebo; Lisa Wissler; Thomas Hansson
We report the discovery of highly potent and selective non-steroidal glucocorticoid receptor modulators with PK properties suitable for inhalation. A high throughput screen of the AstraZeneca compound collection identified sulfonamide 3 as a potent non-steroidal glucocorticoid receptor ligand. Further optimization of this lead generated indazoles 30 and 48 that were progressed to characterization in in vivo models. X-ray crystallography was used to gain further insight into the binding mode of selected ligands.
Archive | 2007
Markus Berger; Jan Dahmén; Anders Eriksson; Balint Gabos; Thomas Hansson; Martin Hemmerling; Krister Henriksson; Svetlana Ivanova; Matti Lepistoe; Darren Mckerrecher; Af Rosenschoeld Magnus Munck; Stinabritt Nilsson; Hartmut Rehwinkel; Camilla Taflin; Karl Edman
Archive | 2002
Joergen Gustafsson; Nafizal Hossain; Stinabritt Nilsson
Archive | 2010
Markus Berger; Jan Dahmen; Karl Edman; Anders Eriksson; Balint Gabos; Thomas Hansson; Martin Hemmerling; Krister Henriksson; Svetlana Ivanova; Matti Lepistö; Darren Mckerrecher; Magnus Munck Af Rosenschöld; Stinabritt Nilsson; Hartmut Rehwinkel; Camilla Taflin
Journal of Medicinal Chemistry | 2017
Martin Hemmerling; Stinabritt Nilsson; Karl Edman; Stefan Eirefelt; Wayne Russell; Ramon Hendrickx; Eskil Johnsson; Carina Kärrman Mårdh; Markus Berger; Hartmut Rehwinkel; Anna Abrahamsson; Jan Dahmén; Anders AstraZeneca R D Lund Eriksson; Balint Gabos; Krister Henriksson; Nafizal Hossain; Svetlana Ivanova; Anne-Helene Jansson; Tina Jellesmark Jensen; Anders Jerre; Henrik Johansson; Tomas Klingstedt; Matti Lepistö; Martin Lindsjö; Irene Mile; Grigorios Nikitidis; John Steele; Ulrika Tehler; Lisa Wissler; Thomas Hansson
Archive | 2010
Thomas Hansson; Stinabritt Nilsson
Archive | 2002
Jörgen Gustafsson; Nafizal Hossain; Stinabritt Nilsson
Archive | 2002
Jörgen Gustafsson; Nafizal Hossain; Stinabritt Nilsson
Archive | 2010
Karl Edman; Jan Dahmén; Thomas Hansson; Nafizal Hossain; Henrik Johansson; Markus Berger; Hartmut Rehwinkel; Matti Lepistoe; Stinabritt Nilsson; Martin Hemmerling
Archive | 2010
Thomas Hansson; Stinabritt Nilsson
