Stuart F. Schlossman

The Development of Monoclonal Antibodies against Human Immunoregulatory T Cell Subsets: The Isolation of Human Suppressor Inducer T Cell Subset

It is now well established that T cells are involved in a complex series of interactions which regulate the immune response (1,2). Considerable impetus to the dissection of T cell heterogeneity came with development of monoclonal antibodies capable of dividing T cells into functionally distinct T4 and T8 populations which also show preferential recognition of class II and I antigens, respectively (3–8).