Su-Hua Wang

Synthesis and antifungal activities of new pyrazole derivatives via 1,3-dipolar cycloaddition reaction.

A series of cycloadducts‐‐pyrazoles via 1,3‐dipolar cycloaddition reactions of generated nitrilimines with N‐(4‐chloro‐2‐fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by 1H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title compounds exhibit significant fungicidal activities against Corynespora cassiicola.

Synthesis of Some N, N′‐Diacylhydrazine Derivatives with Radical‐Scavenging and Antifungal Activity

A series of N,N′‐diacylhydrazines were prepared and their structures were confirmed by 1H NMR, MS and FTICR‐MS. They were tested radical‐scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical‐scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure–activity relationships about the fungicidal activity, a three‐dimensional quantitative structure–activity relationship analysis using the method of comparative molecular field analysis was performed.

Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Thiadiazol Moiety

Thirteen novel sulfonylureas containing thiadiazole moiety were synthesized in a two-step reaction. Their structures were determined using IR, 1H NMR, HRFTMS, and elemental analysis. Herbicidal activities of these compounds were determined in the green house bio-assay. The results show that four compounds among them exhibit some activity toward four tested herbs.

Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing 1,2,4-Triazolinone Moiety

A series of new sulfonylureas incorporating 1,2,4-triazolinone moiety was synthesized, which were further bio-assayed for the herbicidal activity against four herbs, representative of monocotyledons and dicotyledons. Some of them exhibited high potency to inhibit the growth of dicotyledons(Bassica napus and Amaranthus retrofle-xus) in the pot experiment. Compounds 9a and 9b also displayed an excellent herbicidal activity against Bassica napus at a concentration of 15 g/hectare, which were comparable with commercial triasulfuron.

Microwave and ultrasound irradiation-assisted synthesis of novel disaccharide-derived arylsulfonyl thiosemicarbazides

Abstract The synthesis of 1‐arylsulfonyl‐4‐(1′‐N‐hepta‐O‐acetyl‐β‐lactosyl)thiosemicarbazides by reaction of hepta‐O‐acetyl‐α‐D‐lactosyl isothiocyanate with substituted phenylsulfonyl hydrazines has been shown to occur in less than 1 min under microwave activation and 8 min under ultrasound irradiation at room temperature. It is noteworthy that when ultrasound and microwaves (MW) were utilized, a cleaner reaction accompanied with higher yields was observed.

High Throughput Screening Under Zinc-Database and Synthesis a Dialkylphosphinic Acid as a Potential Kari Inhibitor

A novel phosphorus derivative was synthesized through HTVS. The title compounds were confirmed by MS, 1H NMR, 31P NMR. The DOCK was also studied.