Su Huang

A Model-Based, Semi-Global Segmentation Approach for Automatic 3-D Point Landmark Localization in Neuroimages

The existing differential approaches for localization of 3-D anatomic point landmarks in 3-D images are sensitive to noise and usually extract numerous spurious landmarks. The parametric model-based approaches are not practically usable for localization of landmarks that can not be modeled by simple parametric forms. Some dedicated methods using anatomic knowledge to identify particular landmarks are not general enough to cope with other landmarks. In this paper, we propose a model-based, semi-global segmentation approach to automatically localize 3-D point landmarks in neuroimages. To localize a landmark, the semi-global segmentation (meaning the segmentation of a part of the studied structure in a certain neighborhood of the landmark) is first achieved by an active surface model, and then the landmark is localized by analyzing the segmented part only. The joint use of global model-to-image registration, semi-global structure registration, active surface-based segmentation, and point-anchored surface registration makes our method robust to noise and shape variation. To evaluate the method, we apply it to the localization of ventricular landmarks including curvature extrema, centerline intersections, and terminal points. Experiments with 48 clinical and 18 simulated magnetic resonance (MR) volumetric images show that the proposed approach is able to localize these landmarks with an average accuracy of 1 mm (i.e., at the level of image resolution). We also illustrate the use of the proposed approach to cortical landmark identification and discuss its potential applications ranging from computer-aided radiology and surgery to atlas registration with scans.

Regularized fuzzy c-means method for brain tissue clustering

This paper presents a regularized fuzzy c-means clustering method for brain tissue segmentation from magnetic resonance images. A regularizer of the total variation type is explored and a method to estimate the regularization parameter is proposed.

Automatic Segmentation of the Human Brain Ventricles from MR Images by Knowledge-Based Region Growing and Trimming

Automatic segmentation of the human brain ventricular system from MR images is useful in studies of brain anatomy and its diseases. Existing intensity-based segmentation methods are adaptive to large shape and size variations of the ventricular system, but may leak to the non-ventricular regions due to the non-homogeneity, noise and partial volume effect in the images. Deformable model-based methods are more robust to noise and alleviate the leakage problem, but may generate wrong results when the shape or size of the ventricle to be segmented in the images has a large difference in comparison to its model. In this paper, we propose a knowledge-based region growing and trimming approach where: (1) a model of a ventricular system is used to define regions of interest (ROI) for the four ventricles (i.e., left, right, third and fourth); (2) to segment a ventricle in its ROI, a region growing procedure is first applied to obtain a connected region that contains the ventricle, and (3) a region trimming procedure is then employed to trim the non-ventricle regions. A hysteretic thresholding is developed for the region growing procedure to cope with the partial volume effect and minimize non-ventricular regions. The domain knowledge on the shape and intensity features of the ventricular system is used for the region trimming procedure. Due to the joint use of the model-based and intensity-based approaches, our method is robust to noise and large shape and size variations. Experiments on 18 simulated and 58 clinical MR images show that the proposed approach is able to segment the ventricular system accurately with the dice similarity coefficient ranging from 91% to 99%.

A new presentation and exploration of human cerebral vasculature correlated with surface and sectional neuroanatomy.

The increasing complexity of human body models enabled by advances in diagnostic imaging, computing, and growing knowledge calls for the development of a new generation of systems for intelligent exploration of these models. Here, we introduce a novel paradigm for the exploration of digital body models illustrating cerebral vasculature. It enables dynamic scene compositing, real‐time interaction combined with animation, correlation of 3D models with sectional images, quantification as well as 3D manipulation‐independent labeling and knowledge‐related meta labeling (with name, diameter, description, variants, and references). This novel exploration is incorporated into a 3D atlas of cerebral vasculature with arteries and veins along with the surrounding surface and sectional neuroanatomy derived from 3.0 Tesla scans. This exploration paradigm is useful in medical education, training, research, and clinical applications. It enables development of new generation systems for rapid and intelligent exploration of complicated digital body models in real time with dynamic scene compositing from highly parcellated 3D models, continuous navigation, and manipulation‐independent labeling with multiple features. Anat Sci Ed 2:24–33, 2009.

Automatic model-guided segmentation of the human brain ventricular system from CT images.

RATIONALE AND OBJECTIVES Accurate segmentation of the brain ventricular system on computed tomographic (CT) imaging is useful in neurodiagnosis and neurosurgery. Manual segmentation is time consuming, usually not reproducible, and subjective. Because of image noise, low contrast between soft tissues, large interslice distance, large shape, and size variations of the ventricular system, no automatic method is presently available. The authors propose a model-guided method for the automated segmentation of the ventricular system. MATERIALS AND METHODS Fifty CT scans of patients with strokes at different sites were collected for this study. Given a brain CT image, its ventricular system was segmented in five steps: (1) a predefined volumetric model was registered (or deformed) onto the image; (2) according to the deformed model, eight regions of interest were automatically specified; (3) the intensity threshold of cerebrospinal fluid was calculated in a region of interest and used to segment all regions of cerebrospinal fluid from the entire brain volume; (4) each ventricle was segmented in its specified region of interest; and (5) intraventricular calcification regions were identified to refine the ventricular segmentation. RESULTS Compared to ground truths provided by experts, the segmentation results of this method achieved an average overlap ratio of 85% for the entire ventricular system. On a desktop personal computer with a dual-core central processing unit running at 2.13 GHz, about 10 seconds were required to analyze each data set. CONCLUSION Experiments with clinical CT images showed that the proposed method can generate acceptable results in the presence of image noise, large shape, and size variations of the ventricular system, and therefore it is potentially useful for the quantitative interpretation of CT images in neurodiagnosis and neurosurgery.

Segmentation of Liver Vasculature From Contrast Enhanced CT Images Using Context-Based Voting

A novel vessel context-based voting is proposed for automatic liver vasculature segmentation in CT images. It is able to conduct full vessel segmentation and recognition of multiple vasculatures effectively. The vessel context describes context information of a voxel related to vessel properties, such as intensity, saliency, direction, and connectivity. Voxels are grouped to liver vasculatures hierarchically based on vessel context. They are first grouped locally into vessel branches with the advantage of a vessel junction measurement and then grouped globally into vasculatures, which is implemented using a multiple feature point voting mechanism. The proposed method has been evaluated on ten clinical CT datasets. Segmentation of third-order vessel trees from CT images (0.76 × 0.76 × 2.0 mm) of the portal venous phase takes less than 3 min on a PC with 2.0 GHz dual core processor and the average segmentation accuracy is up to 98%.

A fast and automatic method to correct intensity inhomogeneity in MR brain images

This paper presents a method to improve the semi-automatic method for intensity inhomogeneity correction by Dawant et al. through introducing a fully automatic approach to reference points generation, which is based on order statistics and integrates information from the fine to coarse scale representations of the input image. The method has been validated and compared with two popular methods, N3 and BFC. Advantages of the proposed method are demonstrated.

Stroke Suite: Cad Systems for Acute Ischemic Stroke, Hemorrhagic Stroke, and Stroke in ER

We present a suite of computer aided-diagnosis (CAD) systems for acute ischemic stroke, hemorrhagic stroke, and stroke in emergency room. A software architecture common for them is described. The acute ischemic stroke CAD system supports thrombolysis. Our approach shifts the paradigm from a 2D visual inspection of individual scans/maps to atlas-assisted quantification and simultaneous visualization of multiple 2D/3D images. The hemorrhagic stroke CAD system supports the evacuation of hemorrhage by thrombolytic treatment. It aims at progression and quantification of blood clot removal. The clot is automatically segmented from CT time series, its volume measured, and displayed in 3D along with a catheter. A stroke CAD in emergency room enables rapid atlas-assisted decision support regarding the stroke and its location. Our stroke CAD systems facilitate and speed up image analysis, increase confidence of interpreters, and support decision making. They are potentially useful in diagnosis and research, particularly, for clinical trials.

3D Segmentation and Quantification of a Masticatory Muscle from MR Data Using Patient-Specific Models and Matching Distributions

A method is proposed for 3D segmentation and quantification of the masseter muscle from magnetic resonance (MR) images, which is often performed in pre-surgical planning and diagnosis. Because of a lack of suitable automatic techniques, a common practice is for clinicians to manually trace out all relevant regions from the image slices which is extremely time-consuming. The proposed method allows significant time savings. In the proposed method, a patient-specific masseter model is built from a test dataset after determining the dominant slices that represent the salient features of the 3D muscle shape from training datasets. Segmentation is carried out only on these slices in the test dataset, with shape-based interpolation then applied to build the patient-specific model, which serves as a coarse segmentation of the masseter. This is first refined by matching the intensity distribution within the masseter volume against the distribution estimated from the segmentations in the dominant slices, and further refined through boundary analysis where the homogeneity of the intensities of the boundary pixels is analyzed and outliers removed. It was observed that the left and right masseter muscles’ volumes in young adults (28.54 and 27.72cm3) are higher than those of older (ethnic group removed) adults (23.16 and 22.13cm3). Evaluation indicates good agreement between the segmentations and manual tracings, with average overlap indexes for the left and right masseters at 86.6% and 87.5% respectively.

Modeling n-Furcated Liver vessels From a 3-D Segmented Volume Using Hole-Making and Subdivision Methods

It is difficult to build an accurate and smooth liver vessel model due to the tiny size, noise, and n-furcations of vessels. To overcome these problems, we propose an n-furcation vessel tree modeling method. In this method, given a segmented volume and a point indicating the root of the vessels, centerlines and cross-sectional contours of the vessels are extracted and organized as a tree first. Then, the tree is broken up into separate branches in descending order of length, and polygonal meshes of all the branches are separately constructed from the cross-sectional contours. Finally, all the meshes are combined sequentially using our hole-making approach. Holes are made on a coarse mesh, and a final fine mesh is generated using a subdivision method. The hole-making approach with the subdivision method provides good efficiency in mesh construction as well as great flexibilities in mesh editing. Experiments show that our method can automatically construct smooth mesh models for n-furcated vessels with mean absolute error of 0.92 voxel and mean relative error of 0.17. It is promising to be used in diagnosis, analysis, and surgery simulation of liver diseases, and is able to model tubular structures with tree topology.