Su-Kyung Park

Sebaceous Carcinoma: Clinicopathologic Analysis of 29 Cases in a Tertiary Hospital in Korea

Sebaceous carcinoma (SC) is a neoplasm derived from the adnexal epithelium of the sebaceous glands, and most studies on this neoplasm have been conducted in Caucasians. We retrospectively reviewed the records of 29 patients with SC (16 extraocular and 13 ocular lesions) who were diagnosed from 2001 to 2014 to analyze the clinical and histopathological features of SC in the Korean population. Sixteen of the patients were women and 13 were men. There was an equal sex distribution for extraocular lesions, and a female predilection (M:F = 1:1.6) for ocular lesions. The mean ages at presentation of extraocular and ocular lesions were 69.19 ± 37.19 (range, 32–87) and 67.46 ± 24.46 (range, 43–85) years, respectively. Most lesions occurred in the eyelid (13/29, 44.83%), and most extraocular lesions occurred in the head and neck area (13/16, 81.25%). There was no recurrence or death during the follow-up period. Most lesions were poorly differentiated (extraocular, 43.75%; ocular, 38.46%), had a lobular infiltrative growth pattern (extraocular, 68.75%; ocular, 76.92%), and were basaloid (extraocular, 56.25%; ocular, 61.54%). Only 5 cases (2 extraocular and 3 ocular lesions) showed pagetoid spread. Extraocular lesions were marginally more common than the ocular form. There were higher incidences in elderly patients, who also had the highest incidence of eyelid lesions. The proportion of cells with sebaceous differentiation and prominent growth patterns were variable. Our results show that SC may not be very aggressive in Koreans.

New-onset psoriasis induced by rituximab therapy for non-Hodgkin lymphoma in a child.

New onset and exacerbation of psoriasis have rarely been described in patients undergoing rituximab treatment, especially children [1]. Herein, we report the second pediatric case of new-onset plaque-type psoriasis induced by rituximab therapy for non-Hodgkin lymphoma.A 6-year-old Korean boy suffering from CD20-positive large cell non-Hodgkin lymphoma was referred to us for multiple erythematous scaly plaques on the trunk, face, and scalp. He had a 2-year history of chemotherapy with prednisolone, [...]

Digital pebbles without evidence of diabetes: A case report

Dear Editor, A 15-year-old boy presented with a 1-year history of asymptomatic hyperkeratotic plaques on the dorsal sides of both the right proximal and distal interphalangeal joints. He reported no history of trauma or any physical stimulation such as habitual rubbing. Skin examination revealed a diffuse pebbled appearance with the formation of round plaques (Fig. 1a–c). In addition, a pebbly plaque was detected on the dorsum of the right great toe (Fig. 1d). His fasting plasma glucose concentration and hemoglobin A1c level were within normal limits (107 mg/dL and 5.4%, respectively). Histological findings showed hyperkeratosis, epidermal hyperplasia and

Role of Hair Prostheses (Wigs) in Patients with Severe Alopecia Areata

1. My scalp hurts (Sx). 2. My alopecia affects how well I sleep (Fx). 3. I worry that my alopecia may be serious (Em). 4. My alopecia makes it hard to work or do hobbies (Fx). 5. My alopecia affects my social life (Fx). 6. My alopecia makes me feel depressed (Em). 7. My scalp burns or stings (Sx). 8. I tend to stay at home because of my alopecia (Fx). 9. I worry about getting scars from my alopecia (Em). 10. My scalp itches (Sx). 11. My alopecia affects how close I can be with those I love (Fx). 12. I am ashamed of my alopecia (Em). 13. I worry that my alopecia may get worse (Em). 14. I tend to do things by myself because of my alopecia (Fx). 15. I am angry about my alopecia (Em). 16. Water bothers my scalp (bathing, washing hands) (Sx). 17. My alopecia makes showing affection difficult (Fx). 18. My scalp is irritated (Sx). 19. My alopecia affects my interactions with others (Fx). 20. I am embarrassed by my alopecia (Em). 21. My alopecia is a problem for the people I love (Fx). 22. I am frustrated by my alopecia (Em). 23. My scalp is sensitive (Sx). 24. My alopecia affects my desire to be with people (Fx). 25. I am humiliated by my alopecia (Em). 26. My scalp bleeds (Sx). 27. I am annoyed by my alopecia (Em). 28. My alopecia interferes with my sex life (Fx). 29. My alopecia makes me tired (Fx).

Angiokeratomas on the nipple associated with enlargement of the ipsilateral breast: a rare lesion in an adolescent boy

Angiokeratomas are well-circumscribed benign vascular lesions that present as one or more dilated blood vessels in combination with hyperkeratosis, characterized histologically as capillary ectasia in the papillary dermis [1]. Angiokeratomas localized on the nipple have not been reported until now in the literature. We identified a rare and interesting case of angiokeratomas localized on the left nipple of an adolescent boy, associated with enlargement of the ipsilateral breast.A 13-year-old Korean [...]

An unusual case of phakomatosis pigmentovascularis type IIb with Becker's nevus

A six-year-old Korean girl presented with three different types of pigmented and vascular lesions since birth. Physical examination revealed multiple, widespread erythematous patches on her trunk and both legs, left-side hemihypertrophy of the leg, and pitchfork-shaped interdigital gaps of the first interdigital web space of the feet. In addition, a bluish patch on her left forearm and a brownish patch with a geographic outline with breast hypoplasia on the left anterior chest were observed (figures [...]

Pyoderma gangrenosum of the lip involving the oral cavity: a case report and literature review

A 76-year-old male presented with sudden onset of a painful ulcerative lesion involving firstly the lower lip and secondly the oral cavity. The lesion initially started as a nut-sized round erythematous patch on the lower lip and rapidly progressed into a necrotic ulcer within three days (figure 1A). Thereafter, the ulcer gradually extended to the buccal gingiva, teeth, and tip of the tongue (figure 1B). There was no past history of burn or trauma on the area. Six years ago, he was diagnosed with [...]

Angiomyxolipoma of the thumb

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Tumor Necrosis Factor Alpha Blocker-Induced Erythrodermic Sarcoidosis in with Juvenile Rheumatoid Arthritis: A Case Report and Review of the Literature

The development of cutaneous sarcoidosis as a paradoxical adverse event of tumor necrosis factor alpha (TNF-α) blockers has been reported in the literature; however, an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy has not yet been reported. Herein, we report the first case of an erythrodermic form of cutaneous sarcoidosis during anti-TNF-α therapy and review previous studies of cutaneous sarcoidosis. A 6-year-old Korean girl who had been suffering from juvenile rheumatoid arthritis presented with generalized erythematous skin eruption involving more than about 90% of her body surface area. After 14 months of etanercept treatment, the new erythematous skin eruption had developed and progressed into generalized erythroderma. Exclusion of suspected co-medication had been performed based on medication history. She had no other systemic symptoms, and ophthalmologic and neurologic examinations were normal. Histopathologic findings of the skin lesion revealed diffuse non-caseating granulomatous infiltrates composed of epithelioid histiocytes with sparse lymphocytes involving the entire dermis. Periodic-acid-Schiff and acid-fast stains were negative, and acid-fast bacilli was not detected by polymerase chain reaction of the skin biopsy. Based on clinicopathologic findings, she was diagnosed with etanercept-induced sarcoidal granuloma. After discontinuation of the suspected agent, the lesions spontaneously disappeared.

Peristomal basal cell carcinoma treated by wide local excision with secondary healing

The development of carcinoma in relation to a stoma is very rare and may be related to recurrence of previously resected carcinoma or to another primary carcinoma. Different primary carcinomas of the skin have been described at peristomal sites; the development of basal cell carcinoma (BCC) in association with colostomy has been reported only twice before, however [1, 2]. This case is believed to represent the third reported instance of a primary BCC at a peristomal site. The patient was treated [...]