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Featured researches published by Su Yeong Seo.


International Immunopharmacology | 2012

Resveratrol analog, HS-1793 enhance anti-tumor immunity by reducing the CD4+CD25 + regulatory T cells in FM3A tumor bearing mice

Min Ho Jeong; Kwang Mo Yang; Yoo Jin Choi; Sung Dae Kim; Young Hyun Yoo; Su Yeong Seo; Sang Hwa Lee; Seong Ryul Ryu; Chang Min Lee; Hongsuk Suh; Wol Soon Jo

Natural agents with the immunomodulating property have been gaining traction to be employed in the complementary therapy of cancer because the ineffectiveness of numerous therapeutic strategies may be related in part to the tumor-induced immunosuppressive phenotypes, especially regulatory T (Treg) cells found in the tumor microenvironment. The present study was undertaken to examine whether HS-1793, synthetic resvertrol analog free from the restriction of metabolic instability and high dose requirement of resveratrol, induces an in vivo anti-tumor effect in FM3A tumor bearing mice through the suppression of Treg cells, which contribute to an increase in tumor specific cytotoxic T cell responses. Intraperitoneal injections of HS-1793 showed not only therapeutic benefits on established tumors, but also preventive anti-tumor effects. Treg cells (CD4+CD25+Foxp3+ cells) were significantly reduced in the total splenocytes as well as tumor tissues from HS-1793-administered mice, and the production of TGF-β inducing Treg showed a similar pattern. On the contrary, the administration of HS-1793 increased IFN-γ-expressing CD8+ T cells, upregulated IFN-γ production, and enhanced the cytotoxicity of splenocytes against FM3A tumor cells both in therapeutic and preventive experimental animals. These results demonstrated the suppressive role of HS-1793 on the function of Treg cells contributing to tumor specific cytotoxic T lymphocyte responses in tumor-bearing mice, which explained the underlying mechanism of the anti-tumor immunity of HS-1793.


Mycobiology | 2010

The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

Wol Soon Jo; Yoo Jin Choi; Hyoun Ji Kim; Jae Yun Lee; Byung Hyouk Nam; Jae Dong Lee; Sang Wha Lee; Su Yeong Seo; Min Ho Jeong

Abstract The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-α and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.


Toxicological research | 2012

Effects of White Radish (Raphanus sativus) Enzyme Extract on Hepatotoxicity.

Sang Wha Lee; Kwang Mo Yang; Jung Ki Kim; Byung Hyouk Nam; Chang Min Lee; Min Ho Jeong; Su Yeong Seo; Gi Yong Kim; Wol-Soon Jo

Raphanus sativus (Cruciferaceae), commonly known as radish is widely available throughout the world. From antiquity it has been used in folk medicine as a natural drug against many toxicants. The present study was designed to evaluate the hepatoprotective activity of radish (Raphanus sativus) enzyme extract (REE) in vitro and in vivo test. The IC50 values of REE in human liver derived HepG2 cells was over 5,000 μg/ml in tested maximum concentration. The effect of REE to protect tacrine-induced cytotoxicity in HepG2 cells was evaluated by MTT assay. REE showed their hepatoprotective activities on tacrineinduced cytotoxicity and the EC50 value was 1,250 μg/ml. Silymarin, an antihepatotoxic agent used as a positive control exhibited 59.7% hepatoprotective activitiy at 100 μg/ml. Moreover, we tested the effect of REE on carbon tetrachloride (CCl4)-induced liver toxicity in rats. REE at dose of 50 and 100 mg/kg and silymarin at dose of 50 mg/kg were orally administered to CCl4-treated rats. The results showed that REE and silymarin significantly reduced the elevated levels of serum enzyme markers induced by CCl4. The biochemical data were supported by evaluation with liver histopathology. These findings suggest that REE, can significantly diminish hepatic damage by toxic agent such as tacrine or CCl4.


Toxicological research | 2010

Methanolic Extract of Asterina pectinifera inhibits LPS-Induced Inflammatory Mediators in Murine Macrophage

Wol-Soon Jo; Yoo Jin Choi; Hyoun Ji Kim; Byung Hyouk Nam; Gye An Lee; Su Yeong Seo; Sang Wha Lee; Min Ho Jeong

This study aimed to elucidate anti-inflammatory activities from extracts of Asterina pectinifera on nitric oxide (NO) production, TNF-α and IL-6 release in lipopolysaccharide (LPS) -stimulated murine macrophage cell, RAW264.7. We prepared the methanolic extracts (60-MAP, 70-MAP, 80-MAP and 90-MAP) , aqueous extract (W-AP) and functional bioactive compound fraction (He-AP and EA-AP) from Asterina pectinifera according to extract method. The 60-MAP, 70-MAP, 80-MAP, 90-MAP and W-AP were significantly suppressed LPS-induced production NO, TNF-α and IL-6 secretion in a concentration-dependent manner (P < 0.05) . Especially, 80-MAP by extracted 80% methanol had the strongest activity in reduction of inflammatory mediators among these extracts. Indeed, to identify active fraction, which contained potential bioactive compounds, from 80-MAP of Asterina pectinifera, we tested anti-inflammatory activity of the He-AP or the EA-AP. The He-AP was next extracted from 80-MAP and the EA-AP were extracted from the other methanol layer except the He-AP. The EA-AP demonstrated a strong anti-inflammatory effect through its ability to reduce NO production and it also inhibited the production of proinflammatory cytokines such as IL-6 and TNF-α at low concentration. These results suggested that the methanolic extract from Asterina pectinifera had the potential inhibitory effects on the production of these inflammatory mediators.


Molecular & Cellular Toxicology | 2010

In vitro and in vivo anti-inflammatory effects of pegmatite

Wol Soon Jo; Kwang Mo Yang; Yoo Jin Choi; Chang Hwa Jeong; Kyoung Jin Ahn; Byung Hyouk Nam; Sang Wha Lee; Su Yeong Seo; Min Ho Jeong

Pegmatite is a coarse-grained intrusive igneous rock rich in rare elements such as uranium, tungsten, and tantalum with Ca, K, Mg, Fe, Se, Ge, and Ho. We tested in vitro and in vivo assays for the anti-inflammatory activity of pegmatites. We firstly evaluated the suppressive effects of pegmatite on macrophage cell line RAW 264.7 cells stimulated with proinflammatory stimuli lipopolysaccharide (LPS) to determine nitric oxide (NO) production and TNF-α and IL-6 release. The IC50 values of pegmatite exceeded 5,000 μg/mL. Treatment of RAW 264.7 cells with pegmatite significantly inhibited LPS-stimulated NO production and proinflammatory cytokines such as TNF-α and IL-6 secretion in a dose-dependent manner (P<0.05). In vivo studies were tested with two animal models of arachidonic acid-induced mouse ear edema and an acetic acid-induced increase in capillary permeability. The pegmatite significantly attenuated ear edema induced by arachidonic acid and reduced the acetic acid-induced increase in capillary permeability in mice (P<0.05) when the pegmatite was administered topically (10 mg per ear) for 24 h. Therefore, pegmatite potentially shows an anti-inflammatory activity in the in vitro and in vivo mice and in the development of newer anti-inflammatory agents as mineral materials.


Experimental and Therapeutic Medicine | 2012

Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells.

Yoo Jin Choi; Kwang Mo Yang; Sung Dae Kim; Young Hyun Yoo; Sang Wha Lee; Su Yeong Seo; Hongsuk Suh; Sung Tae Yee; Min Ho Jeong; Wol Soon Jo


Anti-Cancer Drugs | 2003

Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin.

Su Yeong Seo; Eun Joo Jun; Sung Moon Jung; Ki-Ho Kim; Young Jin Lim; Bong Soo Park; Jae-Kon Kim; Sung-Eun Lee; Hongsuk Suh; Nam Deuk Kim; Young Hyun Yoo


Food Science and Biotechnology | 2010

Anti-inflammatory Effect of Microalgal Extracts from Tetraselmis suecica

Wol Soon Jo; Yoo Jin Choi; Hyoun Ji Kim; Byung Hyouk Nam; Sook Hee Hong; Gye An Lee; Sang Wha Lee; Su Yeong Seo; Min Ho Jeong


Oncology Reports | 2007

A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells

Su-Bog Yee; Yeon Suk Song; Seung Hun Jeong; Hyung Sik Lee; Su Yeong Seo; Jaehong Kim; Hongsuk Suh; Nam Deuk Kim; Young Hyun Yoo


The Journal of the Korean Society for Microbiology | 1998

Identification of a Lymphocyte Mitogenic Factor Produced by Actinobacillus actinomycetemcomitans

Min Ho Jeong; Jin Mee Song; Sun Mee Park; Su Jin Jeong; Wol Soon Jo; Seung Ho Yoo; Sang Hwa Lee; Sung Tae Yee; Su Yeong Seo; Jung Man Kim

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Hongsuk Suh

Pusan National University

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Sung Tae Yee

Sunchon National University

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Byung Hyouk Nam

Pusan National University

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