Subhash Chandra Gupta

Factor structure of manic symptoms

Objective: The purpose of the present study was to identify the factor structure of manic symptoms as assessed by the Scale for Manic States (SMS). Method: The pattern of symptoms in a group of 225 adults with an ICD-10-DCR diagnosis of manic episode was studied. A factor analysis was conducted of the broad range of psychiatric symptoms covered by SMS. A principal component analysis followed by oblimin rotation was performed. Results: Six eigenvalues were greater than unity and parallel analysis indicated four factors. After observing the scree plot a f ve-factor solution seemed appropriate. Nevertheless, a six-factor solution was chosen that described the data appropriately and was clinically relevant. The six factors (psychosis, irritability aggression, dysphoria, accelerated thought stream, hedonia, and hyperactivity) captured 59.29%% of the total variance. Conclusion: A six-factor solution explains the clinical dimensions of mania in the present sample and dysphoria appeared as a separate factor.

Risperidone-induced galactorrhoea: a case series.

We previously proposed a regime to discontinue paroxetine that, even though helpful in diminishing syndrome incidence, did not prove as successful as we had expected (2). More recently, we have tried other strategies that proved more effective, although still not always successful. Therefore, we feel that an even slower dosage reduction should be attempted. If we are to achieve this in countries such as Spain, where only 20mg tablets are available, manufacturers must produce new forms properly grooved to allow smaller dosages.

Convulsions in the treatment of obsessive-compulsive disorder.

Obsessive–compulsive disorder (OCD) and epilepsy tend to share a close association. However, the exact relationship between OCD symptoms and epileptic convulsions is not well known. A case of OCD who improved remarkably following drug-induced seizures is described, implicating a role for convulsion as an alternative therapeutic modality in OCD.