Sudanese A

Giant cell tumor of bone.

True giant-cell tumors are quite rare. Solitary bone cysts occur with about the same frequency, while sarcomata of bone are found five times as often as either. We agree with Geschickter and Copeland that. there is a close clinical kinship between giant-cell tumor and solitary bone cyst., and tlsat they probably have a common origin. Giant-cell tumors are neoplasms and as such can be expected to recur in sites of incomplete extirpation. Moreover, they may undergo malignant changes, either through trauma or as a result of inadequate treatment. The number and size of the giant cells, together with the number of nuclei pet cell, furnish the best criterion for determining the prognosis. The small, sparsely nucleated giant cells with a tendency for collection of many cells in each high-powered field indicate more activity and rapid growth. These tumors have a greater tendency to recur or become malignant. X-irradiation should be reserved for those lesions inaccessible to surgery. The danger of incomplete cures, recurrence, and of an overdosage of roentgen rays are not as important as the hazard of late sarcomatous changes. Resection of the involved portion of a bone where feasible is the treatment of choice. The distal portion of the radius can be sipplanted successfully by use Proximal end of the fibula. The femoral condyle can be replaced by a section from the ilium. If resection is not practical, the next best method of treatment is thorough curettage, with or without cauterization, together with multiple bone grafts or chips to fill the cavity. The most important single factor in this method applies to the treatment of solitary bone cyst as well as giant-cell tumor: this is thorough curettage, breaking through and destroying the limiting wall and thus opening into the normal cancellous bone of the shaft. Bone chips or grafts should he inserted when large defects are created. The so-called giant-cell variants in most instances are probably separate and distinct pathological lesions resembling this tumor only through the presence of giant cells.Of 327 patients who had a giant-cell tumor of bone and were seen at the Istituto Rizzoli, 293 were treated at the Institute, and 280 of these were followed for two to forty-four years. The distribution according to sex and age of the patient and site of the tumor was similar to the distributions in major reports of large series. The tumor usually involved the metaphysis and the epiphysis, but was occasionally limited to the metaphysis, and in only 2 per cent of the patients was it adjacent to an open growth plate. The tumor on occasion invaded the articular space, also involving the ligaments and the synovial membrane. Extension to an adjacent bone through the joint occurred in 5 per cent of the tumors. Our radiographic grading, which is roughly comparable with the staging system of Enneking et al., was Grade I in 4 per cent, II in 74 per cent, and III in 22 per cent of 266 patients before treatment. A pathological fracture was apparent on the first radiograph in 9 per cent of the patients. In the 280 patients with adequate follow-up, 331 surgical procedures were performed. The rate of local recurrence was 27 per cent in the 151 intralesional procedures, 8 per cent in the 122 marginal excisions, and zero in the fifty-eight wide or radical procedures. These results did not correlate with the radiographic grade of the lesion. Of the fifty-one local recurrences that were seen after treatment at our institution, 90 per cent appeared in the first three years after surgery.(ABSTRACT TRUNCATED AT 250 WORDS)

Histologic evaluation of necrosis in osteosarcoma induced by chemotherapy regional mapping of viable and nonviable tumor

The predominant sites of viable and nonviable tumor were determined in the primary lesions of 50 patients with osteosarcoma after initial treatment with preoperative chemotherapy. The degree of tumor destruction was classified as good, fair, and poor and a map of the sites revealing viable and nonviable tumor was constructed. The study revealed several preferential sites where viable tumor was likely to persist: soft tissues, cortex, subcortex, ligaments, and areas in contact with cartilage (growth plate and/or articular cartilage). Localized areas of hemorrhage and necrosis, designated “lacunae,” were noted within the tumor. They were frequently surrounded by bundles of viable tumor and appeared to correlate with open surgical biopsies. Factors responsible for this phenomenon and the persistence of viable tumor are discussed. The findings have important implications in the design of surgical treatment and in the use of needle biopsies to determine the effects of preoperative treatment. Cancer 56: 1515‐1521, 1985.

Long‐term results in 144 localized Ewing's sarcoma patients treated with combined therapy

The results of 144 previously untreated cases of primary Ewings sarcoma of bone are reported with a minimum follow‐up of 5 years. This series was treated between 1972 and 1982 at Istituto Ortopedico Rizzoli with a combined therapy. The local control of the disease consisted of amputation (ten cases), resection followed by radiation therapy (35‐45 Gy) (48 cases) and radiation therapy alone (40‐60 Gy) (86 cases). Adjuvant chemotherapy, rigorously standardized, was performed according two different protocols: the first (85 cases treated in the period 1972–1978) consisted of vincristine (VCR) Adriamycin (doxorubicin) (ADM), and cyclophosphamide (EDX); the second (59 cases treated in the period 1979‐1982) of VCR, ADM, EDX and dactinomycin (DACT). At a follow‐up of 5 to 16 years (median, 9), 59 patients (41%) are continuously disease‐free (CDF), 81 (56%) developed metastatic disease and/or local recurrence, and four (3%) had a second malignancy. Three factors seem to be correlated to prognosis: the site of the initial lesion (only 23% of the pelvic lesions are represented in the CDF group versus 46% of the other locations); the chemotherapy protocol (32% of the cases in the first protocol are CDF versus 54% in the second); the type of local treatment (60% of the patients treated with amputation or resection plus radiotherapy versus 28% of those treated with radiation therapy alone are CDF). A local recurrence was observed in 24% of the patients (8% in the group locally treated with surgery or surgery plus radiation therapy versus 36% in the group treated with radiation therapy alone). These data suggest that even though adjuvant chemotherapy can improve the long‐term results in localized Ewings sarcoma patients, this disease still represents, in a high percentage of cases, a lethal process whose final prognosis widely depends on the local control of the lesion. Due to the questionable effect of the radiation therapy alone in controlling the primary lesion and its important side effects, the role of surgery in treating Ewings sarcoma of bone should be extended.

Early diagnosis of ceramic liner fracture. guidelines based on a twelve-year clinical experience

Osteolytic lesions due to wear debris are the major long-term problem associated with total hip replacement1. To avoid wear debris, hard-bearing-surface total hip prostheses with improved tribological properties have been introduced into surgical practice. Ceramic surfaces have had some promising long-term results2, and modern metal-backed alumina cups have been associated with very good clinical results3-5. Alumina has excellent tribological properties and a very high Youngs modulus that leads to very good compression strength, but it has poor bending strength: it has no way to deform6. This means that ceramic can break without warning. Under normal physiologic conditions, modern ceramics never reach their fatigue limit, so ceramic head fractures are rare (a rate of 0.004%7 in one study). In contrast, ceramic liner fractures are not well recognized, and their frequency could be underestimated (Fig. 1). In addition, it is difficult to identify patients who are at risk because liner fractures can be due to multiple causes: dislocation, impingement, malpositioning, and microseparation8,9. Fig. 1 A ceramic liner fracture. The diagnosis is often difficult to make on the basis of standard radiographs. A fragment of ceramic is visible near the calcar (arrow). The liner was found to be fractured (arrow) at revision surgery. While many efforts have been made to improve the ceramic manufacturing process and the surgical technique for inserting ceramic components10, little has been reported regarding the early diagnosis of ceramic fracture. When a ceramic fracture involves the liner and is the consequence of repeated microtrauma, the diagnosis is rarely made early, except when ceramic fragments are visible on radiographs. Moreover, decision-making regarding revision surgery after a ceramic-on-ceramic prosthesis has failed is difficult: the ceramic fragments that have spread into the periarticular space are abrasive and …

CT-based surgical planning software improves the accuracy of total hip replacement preoperative planning

The present study is aimed to compare accuracy and the repeatability in planning total hip replacements with the conventional templates on radiographs to that attainable on the same clinical cases when using CT-based planning software. The sizes of the cementless components planned with new computer aided preoperative planning system called Hip-Op and with standard templates were compared to those effectively implanted. The study group intentionally included only difficult clinical cases. The most common aetiology was congenital dysplasia of hip (65.6%). The Hip-Op planning system allowed the surgeons to obtain a preoperative planning more accurate than with templates, especially for the socket. Assuming correct a size planned one calliper above or below that implanted the accuracy increased from 83% for the stem and 69% for the socket when using templates to 86% for the stem and 93% for the socket when using the Hip-Op system. The repeatability of the Hip-Op system was found comparable to that of the template procedure, which is much more familiar to the surgeons. Furthermore, the repeatability of the preoperative planning with the Hip-Op system was consistent between surgeons, independently from their major or minor experience. The study clearly shows the advantages of a three-dimensional computer-based preoperative planning over the traditional template planning, especially when deformed anatomies are involved. The surgical planning performed with the Hip-Op system is accurate and repeatable, especially for the socket and for less experienced surgeons.

Giant-cell tumor of bone with pulmonary metastases: Six case reports and a review of the literature

Giant-cell tumor of bone rarely metastasizes to the lung. In three of six cases, lesions in lung tissue were histologically benign. In 39 such cases reported in the literature, the treatments were surgical extirpation, chemotherapy, and radiation therapy. Resection was indicated to definitely diagnose the pulmonary lesions as benign giant-cell tumors. Radiation therapy and/or chemotherapy may be beneficial as adjuvant treatment, especially where the lesions are anatomically inaccessible. Some pulmonary lesions spontaneously regress even in the absence of definitive treatment.

Cytotoxicity testing of cyanoacrylates using direct contact assay on cell cultures

The use of a tissue adhesive for surgical procedures has prompted a large number of clinical and experimental studies. Alkyl-2-cyanoacrylate esters constitute a family of adhesives with good mechanical properties but their biological compatibility has to be assessed. In this study the cytotoxicity of three commercially available cyanoacrylates and one of unknown composition has been determined. The first part of the study deals with direct contact testing procedures using L 929 cells challenged with drops of adhesives: cell morphology, cell growth and bacterial growth inhibition were assayed. Testing methods included cell viability assay using vital dyes, cell growth measurement using crystal violet staining uptake and bacterial growth assay using S. aureus growth inhibition. All the cyanoacrylate adhesives tested were found to be cytotoxic and to inhibit cell proliferation: differences between the cyanoacrylates were found.

Bone-resorbing cytokines in serum of patients with aseptic loosening of hip prostheses

Our aim was to determine if the serum levels of bone-resorbing cytokines (IL-1beta, TNF-alpha, IL-6, GM-CSF) are altered in patients with aseptic loosening of a total hip prosthesis, and if such levels are influenced by the type of implant. We determined cytokine levels in sera from 35 patients before revision for failed total hip arthroplasty and compared them with those in 25 healthy donors. We also assessed the soluble receptor of interleukin-2 (sIL-2r) in serum as an indication of a specific immune reaction against the implant. Our findings showed that the sIL-2r and TNF-alpha serum level did not change. The IL-6 level was not significantly altered, but was higher in patients with TiAIV prostheses than in those with a CrCoMo implant and in patients with cemented prostheses. The IL-1beta level was found to be higher in those with a TiAIV cemented prosthesis than in the control group (p=0.0001) and other groups of patients (p=0.003 v uncemented TiAIV, p=0.01 v cemented CrCoMo, p=0.001 v uncemented CrCoMo). The GM-CSF level significantly increased in patients compared with healthy subjects (p=0.008), and it was higher in those with cemented than with uncemented implants (p=0.01). Only patients with cementless CrCoMo prostheses had levels of GM-CSF similar to those of the control group. The highest GM-CSF concentrations were observed in patients treated with non-steroidal anti-inflammatory drugs (NSAIDs) in the last months before revision (p=0.04). In addition, when massive osteolysis was observed, the level of GM-CSF tended to decrease to that of the control group.

Giant cell reparative granuloma and other giant cell lesions of the bones of the hands and feet.

The present paper is a clinico-pathologic study of 52 osteolytic lesions containing giant cells, affecting the hands and feet and comprising 11 giant cell reparative granulomas, nine giant cell tumors, six chondroblastomas, and 26 aneurysmal bone cysts. The nature of osteolytic lesions of hands and feet must be carefully established in order to plan appropriate treatment without damaging the surrounding structures. Giant cell reparative granuloma has to be distinguished from other lesions containing giant cells. Clinical and radiologic findings proved of limited diagnostic value; the definitive diagnosis can be established only by histologic examination. Surgical treatment is discussed.

Toxicity of cyanoacrylates in vitro using extract dilution assay on cell cultures

Comparative cytotoxicity testing of four cyanoacrylate adhesives suggested for orthopaedic applications was performed. These substances were placed in complete culture medium with serum and the resulting extraction fluids were tested on L 929 cells and human lymphocytes. Testing procedures include cell morphology assessment using light microscopy and vital dyes, cell counting using a computer-assisted image analysis system, cell growth measurement using total protein content assay and cell viability assessment using the MTT method. Quantitation of the toxicity of the degradation products released by cyanoacrylates in the extracts was achieved and differences in the cytopathic effect related to the chemical composition of the cyanoacrylates were found. A toxicity rating of the assayed cyanoacrylate adhesives was obtained as follows (in order of increasing toxicity): BCA < xCA < ECAg < ECAl.