Sudhir Srivastava

Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?

Preclinical studies are essential for translation to disease treatments and effective use in clinical practice. An undue emphasis on single approaches to Alzheimers disease (AD) appears to have retarded the pace of translation in the field, and there is much frustration in the public about the lack of an effective treatment. We critically reviewed past literature (1990-2014), analyzed numerous data, and discussed key issues at a consensus conference on Brain Ageing and Dementia to identify and overcome roadblocks in studies intended for translation. We highlight various factors that influence the translation of preclinical research and highlight specific preclinical strategies that have failed to demonstrate efficacy in clinical trials. The field has been hindered by the domination of the amyloid hypothesis in AD pathogenesis while the causative pathways in disease pathology are widely considered to be multifactorial. Understanding the causative events and mechanisms in the pathogenesis are equally important for translation. Greater efforts are necessary to fill in the gaps and overcome a variety of confounds in the generation, study design, testing, and evaluation of animal models and the application to future novel anti-dementia drug trials. A greater variety of potential disease mechanisms must be entertained to enhance progress.

Wavelet Based Robust Digital Watermarking Technique Using Reverse Additive Algorithm (RAA)

There are available several watermarking techniques used for data security. Digital media normally assures fairly high quality, nevertheless can be easily reproduced in a perfect form. This perfect reproducibility takes an advantage from certain point of view, while it produces an essential disadvantage, since digital media is frequently copied illegally. A solution of this problem is to embed digital watermark that is not perceived clearly by usual people, but represent the proper right of original product. In this paper a Novel DWT based watermarking technique has been proposed and implemented using MATLAB .This technique shows better performance with respect to robustness and reliability than other existing technique.