Suhong Pang
Bristol-Myers Squibb
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Publication
Featured researches published by Suhong Pang.
Bioorganic & Medicinal Chemistry Letters | 2003
Jagabandhu Das; Robert V. Moquin; James Lin; Chunjian Liu; Arthur M. Doweyko; Henry F. DeFex; Qiong Fang; Suhong Pang; Sidney Pitt; Ding Ren Shen; Gary L. Schieven; Joel C. Barrish; John Wityak
A series of structurally novel benzothiazole based small molecule inhibitors of p56(lck) was prepared to elucidate their structure-activity relationships (SAR), selectivity and cell activity in the T-cell proliferation assay. BMS-350751 (2) and BMS-358233 (3) are identified as potent Lck inhibitors with excellent cellular activities against T-cell proliferation.
Bioorganic & Medicinal Chemistry Letters | 2008
Ashok V. Purandare; Zhong Chen; Tram Huynh; Suhong Pang; Jieping Geng; Wayne Vaccaro; Michael A. Poss; Jonathan O'Connell; Kimberly Nowak; Lata Jayaraman
This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1.
Bioorganic & Medicinal Chemistry Letters | 2009
Tram Huynh; Zhong Chen; Suhong Pang; Jieping Geng; Tiziano Bandiera; Simona Bindi; Paola Vianello; Fulvia Roletto; Sandrine Thieffine; Arturo Galvani; Wayne Vaccaro; Michael A. Poss; George L. Trainor; Matthew V. Lorenzi; Marco M. Gottardis; Lata Jayaraman; Ashok V. Purandare
Design, synthesis, and SAR development led to the identification of the potent, novel, and selective pyrazole based inhibitor (7f) of Coactivator Associated Arginine Methyltransferase (CARM1).
Bioorganic & Medicinal Chemistry Letters | 2009
Honghe Wan; Tram Huynh; Suhong Pang; Jieping Geng; Wayne Vaccaro; Michael A. Poss; George L. Trainor; Matthew V. Lorenzi; Marco M. Gottardis; Lata Jayaraman; Ashok V. Purandare
Hit to Lead optimization and SAR development led to the identification of the potent and selective benzo[d]imidazole inhibitor (17b) of Co-activator Associated Arginine Methyltransferase (CARM1).
Bioorganic & Medicinal Chemistry Letters | 2003
Jagabandhu Das; James Lin; Robert V. Moquin; Zhongqi Shen; Steven H. Spergel; John Wityak; Arthur M. Doweyko; Henry F. DeFex; Qiong Fang; Suhong Pang; Sidney Pitt; Ding Ren Shen; Gary L. Schieven; Joel C. Barrish
A series of structurally novel benzothiazole based small molecule inhibitors of p56(lck) were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in the T-cell proliferation assay. BMS-243117 (compound 2) is identified as a potent, and selective Lck inhibitor with good cellular activity (IC(50)=1.1 microM) against T-cell proliferation.
Bioorganic & Medicinal Chemistry Letters | 2002
Ping Chen; Derek J. Norris; Edwin J. Iwanowicz; Steven H. Spergel; James Lin; Henry H. Gu; Zhongqi Shen; John Wityak; Tai-An Lin; Suhong Pang; Henry de Fex; Sidney Pitt; Ding Ren Shen; Arthur M. Doweyko; Donna A. Bassolino; Jacques Y. Roberge; Michael A. Poss; Bang-Chi Chen; Gary L. Schieven; Joel C. Barrish
We have identified a novel series of 1,5-imidazoquinoxalines as inhibitors of Lck with excellent potency (IC50s<5 nM) as well as good cellular activity against T-cell proliferation (IC50s<1 microM). Structure-activity studies demonstrate the requirement for the core heterocycle in addition to an optimal 2,6-disubstituted aniline group.
Bioorganic & Medicinal Chemistry Letters | 2002
Ping Chen; Edwin J. Iwanowicz; Derek J. Norris; Henry H. Gu; James Lin; Robert V. Moquin; Jagabandhu Das; John Wityak; Steven H. Spergel; Henry de Fex; Suhong Pang; Sydney Pitt; Ding Ren Shen; Gary L. Schieven; Joel C. Barrish
A series of anilino(imidazoquinoxaline) analogues bearing solubilizing side chains at the 6- and 7-positions of the fused phenyl ring has been prepared and evaluated for inhibition against Lck enzyme and of T-cell proliferation. Significant improvement of the cellular activity was achieved over the initial lead, compound 2.
Analytical Biochemistry | 2010
Caroline Fanslau; Donna L. Pedicord; Sujatha Nagulapalli; Hillary Gray; Suhong Pang; Lata Jayaraman; Jonathan Lippy; Yuval Blat
Histone acetyl transferases are important regulators of cellular homeostasis. This study describes a sensitive acetyl transferase electrophoretic mobility shift assay applicable both for kinetic analysis of acetyl transferase inhibitors and for high-throughput testing. Application of the assay for human GCN5L2 enabled dissection of inhibitor competition with respect to acetyl coenzyme A. Furthermore, we demonstrated that the assay can detect time-dependent inhibition of human GCN5L2 by reactive inhibitors.
Journal of Medicinal Chemistry | 2004
Louis J. Lombardo; Francis Y. Lee; Ping Chen; Derek J. Norris; Joel C. Barrish; Kamelia Behnia; Stephen Castaneda; Lyndon A. M. Cornelius; Jagabandhu Das; Arthur M. Doweyko; Craig R. Fairchild; John T. Hunt; Ivan Inigo; Kathy A. Johnston; Amrita Kamath; David Kan; Herbert E. Klei; Punit Marathe; Suhong Pang; Russell Peterson; Sidney Pitt; Gary L. Schieven; Robert J. Schmidt; John S. Tokarski; Mei-Li Wen; John Wityak; Robert M. Borzilleri
Journal of Medicinal Chemistry | 2006
Jagabandhu Das; Ping Chen; Derek J. Norris; Ramesh Padmanabha; James Lin; Robert V. Moquin; Zhongqi Shen; Lynda S. Cook; Arthur M. Doweyko; Sidney Pitt; Suhong Pang; Ding Ren Shen; Qiong Fang; Henry de Fex; Kim W. McIntyre; David J. Shuster; Kathleen M. Gillooly; Kamelia Behnia; Gary L. Schieven; and John Wityak; Joel C. Barrish