Sukhdev Swami Handa

Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase.

Silymarin, a mixture of flavonolignans, comprised mainly of three isomers, silybin, silydianin and silychristin isolated from the fruits of Silybum marianum, is currently in therapeutic use as a hepatoprotective agent. Silymarin on evaluation exhibited significant antiinflammatory and antiarthritic activities in the papaya latex induced model of inflammation and mycobacterial adjuvant induced arthritis in rats. Results of the study indicate its action through inhibition of 5-lipoxygenase for antiinflammatory and antiarthritic activities.

Tinocordifolin, a sesquiterpene from Tinospora cordifolia

A new daucane-type sesquiterpene, tinocordifolin, has been isolated from the stem of Tinospora cordifolia and its structure established by detailed spectroscopic studies.

3α,24-dihydroxy-urs-12-en-28-oic acid from verbena officinalis

A new triterpenoid, 3α,24-dihydroxy-urs-12-en-28-oic acid, has been isolated from the bioactive chloroform extract of aerial parts of Verbena officinalis along with 3α,24-dihydroxy-olean-12-en-28-oic acid and ursolic acid.

Paashaanolactone from Bergenia ligulata

Abstract Four compounds have been isolated from the Bergenia ligulata rhizomes, among which one is new 4(4′-β- d -glucopyranosyloxy-1′-benzoyloxy)-6-methyltetrahydropyran-2-one named as paashaanolactone ( 1 ) and the structure was established by detailed spectroscopic studies.

A sesquiterpene glucoside from Tinospora cordifolia

A new daucane-type sesquiterpene glucoside, tinocordifolioside, has been isolated from the stem of Tinospora cordifolia and the structure was established by detailed spectroscopic studies.