Suleyman Baldane
Erciyes University
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Featured researches published by Suleyman Baldane.
Transfusion and Apheresis Science | 2013
Serdar Sivgin; Suleyman Baldane; Leylagul Kaynar; Fatih Kurnaz; Cigdem Pala; Hulya Sivgin; Muzaffer Keklik; Hayati Demiraslan; Mustafa Cetin; Bulent Eser; Ali Unal
Invasive fungal pneumonia (IFP) has become increasingly common in patients that previously underwent alloHSCT. The aim of this study was to determine the role of hyperferritinemia, via iron overload in invasive fungal pneumonia in patients that underwent alloHSCT. Medical records of 73 patients with pneumonia that underwent alloHSCT were studied retrospectively, whereby a pre-transplantation serum ferritin level measured up to 100 days prior to transplantation of patients with invasive fungal pneumonia (IFP) and non-fungal pneumonia (non-IFP) was compared. Patient records revealed 35 and 38 cases of IFP and non-IFP, respectively. In risk evaluation for IFP, age, gender, HLA status, conditioning regimen, smoking history, and underlying disease were not significantly different among groups (p>0.05). However, performance status (Karnofsky) was significantly lower in patients with IFP (p<0.05). The median ferritin levels were 1,705 ng/ml (41-7198) in the IFP group and 845 ng/ml (18-7099) in non-IFP group and the difference was found statistically significant (p=0.001). Elevated pretransplant serum ferritin level is associated with IFP in patients that underwent alloHSCT, in particular when values exceed 1550 ng/ml.
Transplantation proceedings | 2013
Serdar Sivgin; Suleyman Baldane; T. Ozenmis; Muzaffer Keklik; Leylagul Kaynar; Fatih Kurnaz; Hulya Sivgin; Gokmen Zararsiz; Mustafa Cetin; Aydin Unal; Bulent Eser
OBJECTIVE Serum albumin level is considered to be a marker reflecting the nutritional status in both healthy subjects and patients with malignancies. In this study we sought to investigate the association between pretransplantation serum albumin levels and prognosis among patients with leukemia who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT). METHODS We retrospectively analyzed the data of 102 patients who underwent alloHSCT from 2004 to 2010. Pretransplant serum albumin, D-dimer, creatinine, and fibrinogen levels drawn within 10 days before transplantation were obtained from patient files. All parameters were divided into 2 groups: normal levels (group 1) versus abnormal levels (group 2). Our normal range of serum albumin is 3.2-5.2 g/dL; patients with pretransplantation albumin level ≥3.2 g/dL were included in group 1 versus group 2 with <3.2 g/dL. RESULTS The patients included 42 (41.1%) female and 60 (58.9%) male patients. The diagnoses were acute myeloblastic leukemia in 65 (63.7%) and acute lymphoblastic leukemia in 37 (36.3%). The median age was 26.0 years (range, 13-57). Univariate and multivariate analysis showed that patients with serum albumin levels <3.2 g/dL experienced significantly lower overall survival (OS) compared with ≥3.2 g/dL (hazard ratio [HR] 2.32 [range, 1.23-4.54] and HR 2.70 [range 1.38-5.26], respectively; P = .009). The median (range) OS in group 2 was 230.0 (184.0-544.0) days versus 570.5 (249.5-1,101.0) days in group 1 (P = .007). For disease free survival (DFS) evaluation, univariate and multivariate analysis showed that patients with serum albumin levels <3.2 g/dL had significantly lower values compared with patients with serum albumin ≥3.2 g/dL. (HR 2.17 [range 0.98-4.76] and HR 2.85 [range, 1.25-6.66], respectively; P = .046). The median (range) DFS in group 2 was 184.0 (61.0-524.0) days versus 445.0 (199.0-917.5) days in group 1 (P = .045). Among the patient characteristics the presence of infection was a significant independent variable for worse OS (HR 2.12 [range, 0.98-4.36], P = .036). The other parameters-age, sex, donor status, time to transplant interval, conditioning regimens, HLA status, and number of total infused CD34(+) cells-showed no significant effect on OS and DFS (P = .05). CONCLUSIONS Pretransplantation decreased serum albumin levels were associated with poor survival in patients with leukemia who underwent alloHSCT.
International Journal of Inflammation | 2014
Asuman Celikbilek; Mehmet Celikbilek; Seda Sabah; Nermin Tanik; Elif Borekci; Serkan Dogan; Yavuz Akin; Suleyman Baldane; Kemal Deniz; Neziha Yilmaz; Omer Ozbakir; Mehmet Yucesoy
Objective. Recent studies have demonstrated that enteric glial cells (EGC) participate in the homeostasis of the gastrointestinal tract. This study investigated whether enteroglial markers, including S100B protein and glial fibrillary acidic protein (GFAP), can serve as noninvasive indicators of EGC activation and disease activity in UC patients. Methods. This clinical prospective study included 35 patients with UC and 40 age- and sex-matched controls. The diagnosis of UC was based on standard clinical, radiological, endoscopic, and histological criteria. Clinical disease activity was evaluated using the Modified Truelove-Witts Severity Index. Serum samples were analyzed for human GFAP and S100B using commercial enzyme-linked immunosorbent assay kits. Results. GFAP was not detected in the serum of either UC patients or controls (P > 0.05). However, we found a significant (P < 0.001) decrease in the serum S100B levels in the UC patients. No correlation between the serum S100B level and the disease activity or duration was observed (P > 0.05). The serum S100B levels did not differ between UC patients with active disease (24 patients, 68.6%) or in remission (11 patients, 31.4%) (P > 0.05). Conclusions. Ulcerative colitis patients had significantly lower serum S100B levels, while GFAP was of no diagnostic value in UC patients.
Clinical Lymphoma, Myeloma & Leukemia | 2016
Serdar Sivgin; Suleyman Baldane; Kemal Deniz; Gokmen Zararsiz; Leylagul Kaynar; Mustafa Cetin; Ali Unal; Bulent Eser
AIM Iron overload results in increased infection, venous-oclusive disease and hepatic dysfunction in allogeneic hematopoietic stem cell transplant (alloHSCT) recipients. Liver is one of the most common sites of iron overload. PATIENTS AND METHODS A total of 50 alloHSCT recipients that underwent liver biopsy in Erciyes Stem Cell Transplantation Hospital, Erciyes University, between 2004 and 2011 were enrolled in the study. The liver biopsy specimens have been obtained from the archives of Erciyes University, Department of Pathology and stainned for iron content. RESULTS The mean age was found 34 ± 11 years. For median overall survival (OS); 53 months (min-max: 41-65) in patients with grade 0, 55 months (min-max: 47-64) in patients with grade 1, in patients with grade 2 patients 25.4 months (11.5-39.4 ), grade 3 patients 29.3 months (min-max: 12.3-46.3) and grade 4 patients 2.6 months (min-max: 2.0-3.3). Overall survival was correlated with the degree of liver iron content and it was statistically significant in Kaplan-Meier analysis (P < .001). Disease-free survival was found (DFS); grade 0 patients 47.1 months (min-max: 32.0-62.0), grade 1 patients 36.9 months (min-max: 21.0-65.0), grade 2 patients 23.5 months (min-max: 12.0-59.0), grade 3 patients 27.4 months (min-max: 5.3-59.3) and grade 4 patients 2.6 months (min-max: 2.0-3.0). For DFS; it was negatively correlated with the degree of liver iron content nevertheless; it was not was statistically significant in Kaplan-Meier analysis (P = .093).Hepatic iron overload might be associated with poor survival in patients with transfusional iron overload that underwent alloHSCT. CONCLUSION Hepatic iron content might be associated with poorer prognosis in patients with iron overload that underwent alloHSCT.
Transfusion | 2013
Fatih Kurnaz; Serdar Sivgin; Cigdem Pala; Rahsan Yildirim; Suleyman Baldane; Leylagul Kaynar; Musa Solmaz; Ahmet Öztürk; Bulent Eser; Mustafa Cetin; Ali Unal
Extreme leukocytosis, generally defined as a white blood cell (WBC) count of more than 100 × 109/L consisting largely of blast cells, especially when accompanied by clinical signs and symptoms of leukostasis or hyperviscosity, often predicts a poor clinical outcome in patients with acute leukemia. In this study, we aimed to investigate the effect of volume replacement (VR) during therapeutic leukapheresis (TA) procedure on early mortality rate and WBC reduction.
Journal of Stem Cell Research & Therapy | 2012
Serdar Sivgin; Tahsin Ozenmis; Leylagul Kaynar; Fatih Kurnaz; Hulya Sivgin; Suleyman Baldane; Gokmen Zararsız; Bulent Eser; Ali Unal; Mustafa Cetin
Objectives and aim: Our objective was to investigate the association of pre-transplant Lactate Dehydrogenase (LDH) levels with complications and survival following allogeneic Hematopoietic Stem Cell transplantation (alloHSCT). Materials and methods: We retrospectively analyzed data of 156 patients who had undergone alloHSCT from 2004 to 2010 in Dedeman Stem Cell Transplantation Hospital, Kayseri, Turkey. Pretransplant serum lactate dehydrogenase (LDH), alkaline phosphatase (ALP), creatinin and fibrinogen levels drawn within 7 days prior to transplantation were analyzed with data of transplant procedures. Results: 63 (40.3%) of the patients were female, while 93 (59.7%) were male. The median age was 26 years (min-max:13-57). The median pretransplant serum levels of; LDH was 202U/L (min-max: 71-1202), alkaline phosphatase 83.0 U/L (min-max: 21-379), creatinin 0.70mg/dL (min-max: 0.30-2.40), and fibrinogen 293mg/dL (minmax: 7.0-566.0); respectively. Univariate and multivariate analysis showed that high pre-transplant LDH levels (≥ 246ng /mL) were significantly correlated with decreased disease-free survival (DFS) rates (p=0.037). A higher risk of death was observed in high LDH group both in univariate and multivariate analysis (hazard ratio=2.27, CI: 1.06-3.57 and hazard ratio=1.94, CI: 1.06-3.57; respectively). In univariate analysis; although there was a correlation between high serum LDH levels and decreased rates of OS, this was not statistically significant (hazard ratio=1.31, CI: 0.80- 2.13, p=0.286). There was no statistically significant difference among groups for the parameters ALP, creatinin, CD 34+ cell count, age, gender and diagnosis (p > 0.05). Conclusion: Pre-transplant increased serum LDH levels may be associated with poor survival in patients who have undergone allogeneic hematopoietic stem cell transplantation.
Case Reports in Medicine | 2012
Suleyman Baldane; Serdar Sivgin; Tahsin Sezgin Alkan; Fatih Kurnaz; Cigdem Pala; Muzaffer Keklik; Ahmet Karaman; Leylagul Kaynar
A 59-year-old female patient was admitted to the emergency service with complaints of hematemesis and melena for the last few days. In laboratory tests, the platelet count was found to be 6 × 109/L. Intravenous or oral corticosteroid treatment was thought to be given for ITP but disclaimed due to upper GIS bleeding. On the 5th day of treatment, Brucella melitensis was isolated from blood culture before the results of Wright tube agglutination tests were reported positive as 1 : 80. On the second day of the anti-brucellosis treatment, the thrombocyte count was raised from 6000/mm3 to 110000/mm3, and on the 3rd day to 225000/mm3.
Romanian Journal of Internal Medicine | 2015
Suleyman Baldane; Serdar Sivgin; Leylagul Kaynar; Ozaslan E; Yildririm A; Ozlem Canoz; Bulent Eser
Abstract A 42-year-old male patient was admitted to our hospital for planning autologous hematopoietic stem cell transplantation (auto-HSCT). He was diagnosed as multiple myeloma (IgG type Kappa) in 2003. His physical examination was normal with no important abnormality on laboratory evaluation. Chest radiography performed for routine evaluation prior to transplantation revealed a large, well-defined mass, that had obtuse angles with the chest wall consistent with extraparenchymal lesion superposed on second and third ribs. Also, there were multiple bony structures demonstrating changes of destructive effects of multiple myeloma. Computed tomography (CT)-guided biopsy was obtained from the mass by transthoracic fine-needle aspiration (FNAB) method. Biopsy was reported as extramedullary hematopoiesis (EMH) contrary to our expectation of multiple myeloma.
Neoplasma | 2012
Serdar Sivgin; Suleyman Baldane; Leylagul Kaynar; Fatih Kurnaz; Cigdem Pala; Ahmet Öztürk; Mustafa Cetin; Aydin Unal; Bulent Eser
Transfusion and Apheresis Science | 2013
Serdar Sivgin; Suleyman Baldane; Gulsah Akyol; Muzaffer Keklik; Leylagul Kaynar; Fatih Kurnaz; Cigdem Pala; Gokmen Zararsiz; Mustafa Cetin; Bulent Eser; Ali Unal