Sumangala Bhattacharya
Aarhus University
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Publication
Featured researches published by Sumangala Bhattacharya.
Diabetes, Obesity and Metabolism | 2014
Sumangala Bhattacharya; Niels Oksbjerg; Jette F. Young; Per Bendix Jeppesen
Caffeic acid, naringenin and quercetin are naturally occurring phenolic compounds (PCs) present in many plants as secondary metabolites. The aim of this study was to investigate their effect on glucose‐stimulated insulin secretion (GSIS) in INS‐1E cells and to explore their effect on expression of genes involved in β‐cell survival and function under normoglycaemic and glucotoxic conditions.
Journal of Agricultural and Food Chemistry | 2013
Sumangala Bhattacharya; Kathrine Bisgaard Christensen; Louise Cathrine Braun Olsen; Lars Porskjær Christensen; Kai Grevsen; Nils J. Færgeman; Karsten Kristiansen; Jette F. Young; Niels Oksbjerg
Obesity and insulin resistance in skeletal muscles are major features of type 2 diabetes. In the present study, we examined the potential of Sambucus nigra flower (elderflowers) extracts to stimulate glucose uptake (GU) in primary porcine myotubes and reduce fat accumulation (FAc) in Caenorhabditis elegans. Bioassay guided chromatographic fractionations of extracts and fractions resulted in the identification of naringenin and 5-O- caffeoylquinic acid exhibiting a significant increase in GU. In addition, phenolic compounds related to those found in elderflowers were also tested, and among these, kaempferol, ferulic acid, p-coumaric acid, and caffeic acid increased GU significantly. FAc was significantly reduced in C. elegans, when treated with elderflower extracts, their fractions and the metabolites naringenin, quercetin-3-O-rutinoside, quercetin-3-O-glucoside, quercetin-3-O-5″-acetylglycoside, kaempferol-3-O-rutinoside, isorhamnetin-3-O-rutinoside, and isorhamnetin-3-O-glucoside and the related phenolic compounds kaempferol and ferulic acid. The study indicates that elderflower extracts contain bioactive compounds capable of modulating glucose and lipid metabolism, suitable for nutraceutical and pharmaceutical applications.
Food & Function | 2015
Rime Bahij El-Houri; Dorota Ewa Kotowska; Kathrine Bisgaard Christensen; Sumangala Bhattacharya; Niels Oksbjerg; Gerhard Wolber; Karsten Kristiansen; Lars Porskjær Christensen
A dichloromethane (DCM) extract of carrot roots was found to stimulate insulin-dependent glucose uptake (GU) in adipocytes in a dose dependent manner. Bioassay-guided fractionation of the DCM extract resulted in the isolation of the polyacetylenes falcarinol and falcarindiol. Both polyacetylenes were able to significantly stimulate basal and/or insulin-dependent GU in 3T3-L1 adipocytes and porcine myotube cell cultures in a dose-dependent manner. Falcarindiol increased peroxisome proliferator-activated receptor (PPAR)γ-mediated transactivation significantly at concentrations of 3, 10 and 30 μM, while PPARγ-mediated transactivation by falcarinol was only observed at 10 μM. Docking studies accordingly indicated that falcarindiol binds to the ligand binding domain of PPARγ with higher affinity than falcarinol and that both polyacetylenes exhibit characteristics of PPARγ partial agonists. Falcarinol was shown to inhibit adipocyte differentiation as evident by gene expression studies and Oil Red O staining, whereas falcarindiol did not inhibit adipocyte differentiation, which indicates that these polyacetylenes have distinct modes of action. The results of the present study suggest that falcarinol and falcarindiol may represent scaffolds for novel partial PPARγ agonists with possible antidiabetic properties.
Evidence-based Complementary and Alternative Medicine | 2014
Rime Bahij El-Houri; Dorota Ewa Kotowska; Louise Cathrine Braun Olsen; Sumangala Bhattacharya; Lars Porskjær Christensen; Kai Grevsen; Niels Oksbjerg; Nils J. Færgeman; Karsten Kristiansen; Kathrine Bisgaard Christensen
Dichloromethane and methanol extracts of seven different food and medicinal plants were tested in a screening platform for identification of extracts with potential bioactivity related to insulin-dependent glucose uptake and fat accumulation. The screening platform included a series of in vitro bioassays, peroxisome proliferator-activated receptor (PPAR) γ-mediated transactivation, adipocyte differentiation of 3T3-L1 cell cultures, and glucose uptake in both 3T3-L1 adipocytes and primary porcine myotubes, as well as one in vivo bioassay, fat accumulation in the nematode Caenorhabditis elegans. We found that dichloromethane extracts of aerial parts of golden root (Rhodiola rosea) and common elder (Sambucus nigra) as well as the dichloromethane extracts of thyme (Thymus vulgaris) and carrot (Daucus carota) were able to stimulate insulin-dependent glucose uptake in both adipocytes and myotubes while weekly activating PPARγ without promoting adipocyte differentiation. In addition, these extracts were able to decrease fat accumulation in C. elegans. Methanol extracts of summer savory (Satureja hortensis), common elder, and broccoli (Brassica oleracea) enhanced glucose uptake in myotubes but were not able to activate PPARγ, indicating a PPARγ-independent effect on glucose uptake.
Human & Experimental Toxicology | 2010
Jette F. Young; Sumangala Bhattacharya
The lead article ‘‘Resveratrol commonly displays hormesis: occurrence and biomedical significance’’ underlines the hormetic response of resveratrol in many disease models. This commentary suggests that the greatest potential advantage of the positive effects of resveratrol for the broad population would be as prevention of disease development through oral administration in its original food matrix, although it still remains important to investigate the extent of resveratrol administration giving maximum beneficial effect for biomedical purposes. In relation to resveratrol ‘‘supplementation’’ through its natural environment further investigation of the impact of co-occurring bioactive compounds and matrix effects on hormetic responses of resveratrol is necessary for revealing mechanisms behind e.g. the ‘‘French paradox’’.
Journal of Biochemical and Pharmacological Research | 2014
Sumangala Bhattacharya; Martin Krøyer Rasmussen; Lars Porskjær Christensen; Jette F. Young; Karsten Kristiansen; Niels Oksbjerg
Planta Medica | 2010
Knud Villy Christensen; Dorota Ewa Kotowska; L Olsen; Sumangala Bhattacharya; Xavier Fretté; Nils J. Færgeman; Karsten Kristiansen; Niels Oksbjerg; Kai Grevsen; Lars Porskjær Christensen
Planta Medica | 2010
Knud Villy Christensen; Louise Cathrine Braun Olsen; Dorota Ewa Kotowska; Sumangala Bhattacharya; Xavier Fretté; Nils J. Færgeman; Karsten Kristiansen; Niels Oksbjerg; Lars Porskjær Christensen
7th Nordic Natural Products Conference | 2017
Rime Bahij El-Houri; Dorota Ewa Kotowska; Sumangala Bhattacharya; Gerhard Wolber; Niels Oksbjerg; Karsten Kristiansen; Lars Porskjær Christensen
Archive | 2015
Rime Bahij El-Houri; Dorota Ewa Kotowska; Kathrine Bisgaard Christensen; Sumangala Bhattacharya; Niels Oksbjerg; Gerhard Wolber; Karsten Kristiansen; Lars Porskjær Christensen