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Sumei Ruan

Wichita State University

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Publication

Featured researches published by Sumei Ruan.

Bioorganic & Medicinal Chemistry Letters | 1998

Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

Rongze Kuang; Radhika Venkataraman; Sumei Ruan; William C. Groutas

The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE).

Biochemistry | 1997

Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.

William C. Groutas; Rongze Kuang; Radhika Venkataraman; Jeffrey B. Epp; Sumei Ruan; Om Prakash

Bioorganic & Medicinal Chemistry | 1998

Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

William C. Groutas; Rongze Kuang; Sumei Ruan; Jeffrey B. Epp; Radhika Venkataraman; Tien M. Truong

Journal of the American Chemical Society | 1999

A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold: Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

Rongze Kuang; Jeffrey B. Epp; Sumei Ruan; Hongyi Yu; Peng Huang; Shu He; Juan Tu; Norman M. Schechter; Jane Turbov; and Christopher J. Froelich; William C. Groutas

Bioorganic & Medicinal Chemistry | 2001

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

William C. Groutas; Shu He; Rongze Kuang; Sumei Ruan; Juan Tu; Ho-Kit Chan

Archives of Biochemistry and Biophysics | 2001

1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases

William C. Groutas; Jeffrey B. Epp; Rongze Kuang; Sumei Ruan; Lee S. Chong; Radhika Venkataraman; Juan Tu; Shu He; Hongyi Yu; Qinghong Fu; Yue He Li; Tien M. Truong; Nga T. Vu

Biochemical and Biophysical Research Communications | 1997

Inhibition of Human Leukocyte Proteinase 3 by a Novel Recombinant Serine Proteinase Inhibitor (LEX032)

William C. Groutas; Sumei Ruan; Rongze Kuang; Jerry B. Hook; Howard Sands

NLM | 1998

Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

William C. Groutas; Rongze Kuang; Sumei Ruan; Jeffrey B. Epp; Radhika Venkataraman; Tien M. Truong

NLM | 2001

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

William C. Groutas; Shu He; Rongze Kuang; Sumei Ruan; Juan Tu; Ho-Kit Chan

NLM | 2000

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

Rongze Kuang; Jeffrey B. Epp; Sumei Ruan; Lee S. Chong; Radhika Venkataraman; Juan Tu; Shu He; Tien M. Truong; William C. Groutas

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Rongze Kuang

Wichita State University

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William C. Groutas

Wichita State University

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Jeffrey B. Epp

Wichita State University

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Radhika Venkataraman

Wichita State University

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Juan Tu

Wichita State University

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Shu He

Wichita State University

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Tien M. Truong

Wichita State University

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Ho-Kit Chan

Wichita State University

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Hongyi Yu

Wichita State University

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Lee S. Chong

Wichita State University

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