Sumei Ruan | Researchain

Archive Network Publication Hotspot Collaboration

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Sumei Ruan is active.

Explore More

Publication

Featured researches published by Sumei Ruan.

Bioorganic & Medicinal Chemistry Letters | 1998

Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases

Rongze Kuang; Radhika Venkataraman; Sumei Ruan; William C. Groutas

The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase (HLE).

Biochemistry | 1997

Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.

William C. Groutas; Rongze Kuang; Radhika Venkataraman; Jeffrey B. Epp; Sumei Ruan; Om Prakash

Bioorganic & Medicinal Chemistry | 1998

Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

William C. Groutas; Rongze Kuang; Sumei Ruan; Jeffrey B. Epp; Radhika Venkataraman; Tien M. Truong

Journal of the American Chemical Society | 1999

A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold: Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors

Rongze Kuang; Jeffrey B. Epp; Sumei Ruan; Hongyi Yu; Peng Huang; Shu He; Juan Tu; Norman M. Schechter; Jane Turbov; and Christopher J. Froelich; William C. Groutas

Bioorganic & Medicinal Chemistry | 2001

Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold.

William C. Groutas; Shu He; Rongze Kuang; Sumei Ruan; Juan Tu; Ho-Kit Chan

Archives of Biochemistry and Biophysics | 2001

1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases

William C. Groutas; Jeffrey B. Epp; Rongze Kuang; Sumei Ruan; Lee S. Chong; Radhika Venkataraman; Juan Tu; Shu He; Hongyi Yu; Qinghong Fu; Yue He Li; Tien M. Truong; Nga T. Vu

Biochemical and Biophysical Research Communications | 1997