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Featured researches published by Sumit Govil.


Phytomedicine | 2017

Metabolomic and Biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A Review

Niraj Tripathi; Divya Shrivastava; Bilal Ahmad Mir; Shailesh Kumar; Sumit Govil; Maryam Vahedi; P. S. Bisen

BACKGROUND Withania somnifera, a high value medicinal plant is a major source of pharmaceutically important active compounds withanolides. Withania somnifera has been used in ayurveda as health restorative and anabolic agent besides having anti-arthritic, antidepressant, anti-microbial, anti-inflammatory, anti-diabetic, anti-stress, neuroprotective and cardio-protective activities. HYPOTHESIS/PURPOSE The mining of the compound(s) of interest offers opportunity to identify desired attributes in the therapeutic area of interest. Metabolomic has become an important tool in the field of pharmacological and functional genomics of medicinal plants. The analysis supports the information regarding differential outline of the gene expression for increasing important withanolides viz. withanolide A and withaferin A in W. somnifera. STUDY DESIGN The bioinformatics and biotechnological approaches viz. tissue culture, genetic transformation, genomic, transcriptomic, proteomic, gene mining and metabolomic studies have opened new windows about engineering of withanolide production. METHODS Target and network analysis for maximum therapeutic potential of Withania somnifera have been determined by employing Genemania software for finding interactions among various human genes that are being affected by active constituents. RESULTS Some of the major bioactive compounds of Withania somnifera have been discussed on protein-protein, protein-DNA and genetic interactions with respect to gene and protein expression data, protein domains, metabolic profiling, root organ culture, genetic transformation and phenotypic screening profiles CONCLUSION: The implementation of latest bioinformatic tools in combination with biotechnological techniques for breeding platforms are important in conservation of medicinal plant species in danger. The current review is based on molecular and in vitro methodologies employed in W. somnifera for accepting their importance in the improvement of this valuable medicinal species.


The Natural Products Journal | 2016

A Novel Anticandidal Compound Containing Sulfur from Endophytic Fungus Emericella sp.

Shweta Mittal; Divya Shrivastava; Sumit Govil; Shailesh Kumar; Prakash S. Bisen


Archive | 2014

Computational 3D Structure Prediction, Evaluation and Analysis of Pyruvate Dehydrogenase an Effective Target for Filarial Infection by Brugia pahangi Using Homology Modeling Approach

Shailesh Kumar; Onkar Nath; Sumit Govil; A. N. Pathak


ISABB Journal of Biotechnology and Bioinformatics | 2012

Computational studies on Ribavirin binding to RNA-dependent RNA polymerase, inducing Crimean-Congo hemorrhagic fever

Shailesh Kumar; Abhishek Tyagi; Sumit Govil; Sanjay Mishra


Asian Journal of Pharmacy and Pharmacology | 2018

Identification of key miRNA biomarkers by miRNA-gene interactions network regulating breast cancer in human

Shailesh Kumar; Sumit Govil; Vikram Kumar; Sumita Kachhawah; S. L. Kothari


Annals of Plant Sciences | 2018

In-silico identification of cis- acting regulatory elements in 5’ regulatory region of Betaine aldehyde dehydrogenase isoenzymes of selected monocot and dicot

Hemani Sharma; Sumit Govil; Divya Shrivastava


American Journal of Biotechnology and Bioinformatics | 2018

Comparison of Sequence with Cluster based analysis for molecular properties and composition of Glutathione Peroxidase family proteins

Shailesh Kumar; Sumit Govil; Vikram Kumar


International journal of pharma and bio sciences | 2017

Computational prediction of mi-rnas responsible for gene silencing in helianthus tuberosus by using cross phylogeny approach with Arabidopsis Thaliana

Sumit Govil; Shailesh Kumar


The Natural Products Journal | 2016

Therapeutic Applications of Crocus sativus L. (Saffron): A Review

Maryam Vahedi; Sumit Govil; Shailesh Kumar; Divya Shrivastava; Roghaye Karimi; Prakash S. Bisen


Archive | 2014

Algorithms and databases: A key to solve genetic equation in Next Generation Sequencing

Shailesh Kumar; Sumit Govil; Sheema Sadana; A. N. Pathak

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Shailesh Kumar

Amity Institute of Biotechnology

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Divya Shrivastava

Jaipur National University

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Hemani Sharma

Jaipur National University

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P. S. Bisen

Jaipur National University

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