Sumit Govil
Jaipur National University
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Featured researches published by Sumit Govil.
Phytomedicine | 2017
Niraj Tripathi; Divya Shrivastava; Bilal Ahmad Mir; Shailesh Kumar; Sumit Govil; Maryam Vahedi; P. S. Bisen
BACKGROUND Withania somnifera, a high value medicinal plant is a major source of pharmaceutically important active compounds withanolides. Withania somnifera has been used in ayurveda as health restorative and anabolic agent besides having anti-arthritic, antidepressant, anti-microbial, anti-inflammatory, anti-diabetic, anti-stress, neuroprotective and cardio-protective activities. HYPOTHESIS/PURPOSE The mining of the compound(s) of interest offers opportunity to identify desired attributes in the therapeutic area of interest. Metabolomic has become an important tool in the field of pharmacological and functional genomics of medicinal plants. The analysis supports the information regarding differential outline of the gene expression for increasing important withanolides viz. withanolide A and withaferin A in W. somnifera. STUDY DESIGN The bioinformatics and biotechnological approaches viz. tissue culture, genetic transformation, genomic, transcriptomic, proteomic, gene mining and metabolomic studies have opened new windows about engineering of withanolide production. METHODS Target and network analysis for maximum therapeutic potential of Withania somnifera have been determined by employing Genemania software for finding interactions among various human genes that are being affected by active constituents. RESULTS Some of the major bioactive compounds of Withania somnifera have been discussed on protein-protein, protein-DNA and genetic interactions with respect to gene and protein expression data, protein domains, metabolic profiling, root organ culture, genetic transformation and phenotypic screening profiles CONCLUSION: The implementation of latest bioinformatic tools in combination with biotechnological techniques for breeding platforms are important in conservation of medicinal plant species in danger. The current review is based on molecular and in vitro methodologies employed in W. somnifera for accepting their importance in the improvement of this valuable medicinal species.
The Natural Products Journal | 2016
Shweta Mittal; Divya Shrivastava; Sumit Govil; Shailesh Kumar; Prakash S. Bisen
Archive | 2014
Shailesh Kumar; Onkar Nath; Sumit Govil; A. N. Pathak
ISABB Journal of Biotechnology and Bioinformatics | 2012
Shailesh Kumar; Abhishek Tyagi; Sumit Govil; Sanjay Mishra
Asian Journal of Pharmacy and Pharmacology | 2018
Shailesh Kumar; Sumit Govil; Vikram Kumar; Sumita Kachhawah; S. L. Kothari
Annals of Plant Sciences | 2018
Hemani Sharma; Sumit Govil; Divya Shrivastava
American Journal of Biotechnology and Bioinformatics | 2018
Shailesh Kumar; Sumit Govil; Vikram Kumar
International journal of pharma and bio sciences | 2017
Sumit Govil; Shailesh Kumar
The Natural Products Journal | 2016
Maryam Vahedi; Sumit Govil; Shailesh Kumar; Divya Shrivastava; Roghaye Karimi; Prakash S. Bisen
Archive | 2014
Shailesh Kumar; Sumit Govil; Sheema Sadana; A. N. Pathak