Sunita Jain

Antimicrobial screening of Cassia occidentalis L. in vivo and in vitro

Ethanol extracts of different parts and the calli of Cassia occidentalis, and sequential extracts (petroleum ether, benzene, chloroform, ethanol and water) of whole plant and metabolite‐rich fractions (anthraquinones, sennosides and flavonoids) of leaves, pods, flowers and callus have been tested against indicator human pathogenic bacteria and fungi. Likewise, an ethanol extract (whole plant) was tested against selected viruses and for antitumour and cytotoxicity following established protocols. The anthraquinones were found to be more active against E. coli and S. aureus (IZ 22 mm) while sennosides were more active against A. flavus (IZ 28 mm). However, no antiviral, antitumour or cytotoxicity effect was exhibited against the test systems.

A 1,4-Anthraquinone derivative from Tectona grandis

Abstract A petrol extract of the heartwood of Tectona qrandis afforded a new 9,10-dimethoxy-2-methyl anthra-1,4- quinone along with tecomaquinone I and several known naptho- and anthra-quinone derivatives. The structure of the new quinone was elucidated by high field 1 H NMR and NOE studies.

Studies in fluorinated 1,3-diketones and related compounds. Part XVII. Synthesis and spectroscopic studies of some new 5-alkyl-3-fluoroaryl-1-pentafluoroaryl-pyrazoles and 2-amino-6-alkyl(perfluoroalkyl)-4-aryl pyrimidines

Abstract Six new 3-(4′-fluorophenyl)-1,5-trisubstituted pyrazoles have been synthesized from the appropriate fluorinated 1,3-diketones and pentafluorophenylhydrazine in the presence of absolute ethanol and hydrochloric acid, viz., 1-pentafluorophenyl-3-(4′-fluorophenyl)-5- methylpyrazole, 1-pentafluorophenyl-3-(4′-fluorophenyl)-5-trifluoromethylpyrazole, 5- ethyl-1-pentafluorophenyl-3-(4′-fluorophenyl) pyrazole, 5-(pentafluoroethyl)-1-pentafluorophenyl-3-(4′-fluorophenyl) pyrazole, 1-pentafluorophenyl-3-(4′-fluorophenyl) 5-n-propylpyrazole and 5-(heptafluoropropyl)-1-pentafluorophenyl-3-(4′-fluorophenyl) pyrazole. In addition, six new 2-amino-4-(4′-fluorophenyl)-6-alkyl(perfluoroalkyl)-trisubstituted pyrimidines have been prepared from the same diketones and guanidine carbonate in the presence of hydrochloric acid using absolute ethanol as a solvent, viz., 2-amino- 4(4′-fluorophenyl)-6-methylpyrimidine, 2-amino-4(4′-fluorophenyl)-6-trifluoromethylpyrimidine, 2-amino-6-ethyl-4(4′-fluorophenyl)pyrimidine, 2-amino-6-pentafluoroethyl-4-(4′-fluorophenyl)pyrimidine, 2-amino-4-(4′-fluorophenyl)-6-n-propylpyrimidine and 2- amino-6-(heptafluoropropyl)-4-(4′-fluorophenyl)pyrimidine. All new fluorinated pyrazoles as well as pyrimidines have been characterized by elemental analyses as well as spectral studies.