Sunita Singh

Cyproheptadine adverse drug interaction with anti-epileptic drugs

Histamine is found to take part in the inhibition of seizures via H1 and5HT1/2 histamine receptors. In past epileptic patients were frequently prescribed cyproheptadine, as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of ‘serotonin syndrome’ in depressed epileptic patients. Cyproheptadine antagonizing subtypes of 5HT1/2 receptors and H1 receptor and decreases neurotransmission of serotonin, which in turn reduces seizures threshold.

Pre-treatment effect of myo-inositol and l-5, methyltetrahydrofolate in ovulation induction oocyte quality and pregnancy outcome in clomiphene resistance polycystic ovarian disease

Although the etiology of PCOS is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, metabolic, endocrine and environmental abnormalities. There is increasing evidence suggesting that PCOS affects the whole life of a woman, can begin in utero in genetically predisposed subjects, it manifests clinically at puberty, continues during the reproductive years. It can also expose patients to increased risk of cardiovascular disease, hypertension, diabetes and other metabolic complications, especially after menopause. During the fertile period it may cause anovulatory infertility and could be associated with increased prevalence of gestational complications, such as miscarriage, gestational diabetes and preeclampsia. The quality of oocytes plays a key role in the development of a ABSTRACT

Management of Alternaria Blight through Genotypes, Fungicides, Bio-Agents and Botanical in Rapeseed-Mustard

ISSN: 2319-7706 Volume 7 Number 02 (2018) Journal homepage: http://www.ijcmas.com Alternaria blight caused by Alternaria brassicae (Berk) Sacc. and A. brassicicola (Schw) Wiltshire is one of the most common and destructive disease of rapeseedmustard. The experiments were conducted under field condition to develop effective management strategies for this disease through evaluation of genotypes for resistance and application of fungicide, bio-agents and botanical. Out of 200 promising genotypes evaluated for resistance, none of the entry was found resistant, twenty two genotypes namely DLSC-1, DRMR-261, DRMR-270, GSC-101, GSL-1, NPC-20 and PHR-2, CNH-11-13, CNH-11-7, EC-552608, HNS-1001, PAB 04-10, PAB 05-16, PAB 05-19, PAB 09-05, PAB-2004-4, PAB-2005-16, PPBJ 5, PPBJ-2, PPBJ-3, PPBN 3 and PPBN-2 were moderately resistant and 63 genotypes moderately susceptible. Seed treatment with Apron @ 6g/Kg seed and spray of all fungicides, bio-agents and botanical extract, significantly reduced the blight severity in comparison to the untreated control (water spray). Of the fungicides, Nativo @ 0.05% was found most effective followed by Difenconazole @ 0.05%, Iprodione @ 0.2, Folicure @ 0.2, Difolatan@ 0.2, Mancozeb @ 0.2, Antracol @ 0.25, Pseudomonas fluorescens @ 1.0, Trichoderma harzianum @ 1.0 and Garlic bulb extract @ 1.0 which showed 8.70%, 14.62%, 16.27%, 16.41%, 18.54%, 20.51%, 21.42%, 24.27%, 25.42%, and 26.83%, severity, respectively after third spray of each chemical, bio-agents and botanical extract. The disease severity of water spray control was 69.10%. Same tread was also recorded with per cent disease control. Maximum seed yield (kg/ha) and yield increase (%) of 1740.22, 37.90 was recorded with the treatment Nativo @ 0.05% followed by Difenconazole @ 0.05% (1629.61, 29.16), Iprodione @ 0.2 (1617.11, 28.17), Folicure @ 0.2 (1587.50, 25.85), Trichoderma harzianum @ 1.0 (1525.68, 20.93), Difolatan @ 0.2 (1516.98, 2024), Pseudomonas fluorescens @ 1.0 (1512.37, 1987), Antracol @ 0.25 (1511.45,19.80), Mancozeb @ 0.2 (1507.99, 19.52), respectively. The maximum benefit cost ratio 1:12.60 was obtained with Garlic bulb extract @1.0 followed by Trichoderma harzianum @ 1.0 (1:6.0), Nativo @ 0.05% (1:4.01), Pseudomonas flurescence @ 1.0 (1:3.79). K e y w o r d s Rapeseed and mustard, Alternaria blight, Management Accepted: 20 January 2018

A Study of Awareness & Attitude of Medical Students towards HIV/AIDS at SIMS, Hapur, Uttar Pradesh

The present study highlighted that 100% of medical students were aware of HIV/AIDS. However there were misconceptions regarding the mode of spread, incomplete knowledge about transmission of disease, incomplete knowledge about high risk groups for HIV/AIDS and preventive measures against HIV/AIDS. Students feel that they need to know more about HIV. So the students need intensive preclinical experience to enhance their knowledge. This must continue during the clinical years.