Sunny Abraham

Addition of pyrroles to electron deficient olefins employing InCl3

Pyrroles undergo conjugate addition with electron deficient olefins in the presence of a catalytic amount of indium trichloride at ambient temperature to afford the corresponding Michael adducts in excellent yields with high selectivity without polymerisation.

InCl3-catalyzed regioselective opening of aziridines with heteroaromatics

A variety of N-tosylaziridines undergo ring opening with pyrrole, furan, thiophene and indole in the presence of a catalytic amount of indium trichloride at ambient temperature to afford the corresponding β-aminoheterocycles in good yields with high regioselectivity.

Deprotection of sulfonamides using iodotrimethylsilane

The deprotection of sulfonamides is achieved under neutral conditions by reaction with iodotrimethylsilane in acetonitrile at reflux.

Towards the synthesis of (+)-discodermolide ☆

Abstract An approach to the asymmetric synthesis of fragments corresponding to C1C7 and C15C24 of (+)-discodermolide is reported. Key elements of the successful strategy include elaboration of two advanced fragments from a common precursor.

Microwave promoted synthesis of β-aminoalcohols in dry media†

Aminolysis of eposides with ammonium acetate has been achieved for the first time under microwave irradation conditions. This reaction is regioselective and affords β-aminoalcohols in good yields.

A facile method for the preparation and cleavage of 1,1-diacetates of aldehydes

A convenient method for the preparation and cleavage of 1,1-diacetates of aldehydes is reported using AlCl 3 as catalyst.