Supin Wang

Dynamic Changes of Integrated Backscatter, Attenuation Coefficient and Bubble Activities During High-Intensity Focused Ultrasound (HIFU) Treatment

This paper simultaneously investigated the transient characteristics of integrated backscatter (IBS), attenuation coefficient and bubble activities as time traces before, during and after HIFU treatment, with different HIFU parameters (acoustic power and duty cycle) in both transparent tissue-mimicking phantoms and freshly excised bovine livers. These dynamic changes of acoustic parameters and bubble activities were correlated with the visualization of lesion development selected from photos, conventional B-mode ultrasound images and differential IBS images over the whole procedure of HIFU treatment. Two-dimensional radiofrequency (RF) data were acquired by a modified diagnostic ultrasound scanner to estimate the changes of mean IBS and attenuation coefficient averaged in the lesion region, and to construct the differential IBS images and B-mode ultrasound images simultaneously. Bubble activities over the whole procedure of HIFU treatment were investigated by the passive cavitation detection (PCD) method and the changes in subharmonic and broadband noise were correlated with the transient characteristics of IBS and attenuation coefficient. When HIFU was switched on, IBS and attenuation coefficient increased with the appearance of bubble clouds in the B-mode and differential IBS image. At the same time, the level of subharmonic and broadband noise rose abruptly. Then, there was an initial decrease in the attenuation coefficient, followed by an increase when at lower HIFU power. As the lesion appeared, IBS and attenuation coefficient both increased rapidly to a value twice that of normal. Then the changes in IBS and attenuation coefficient showed more complex patterns, but still showed a slower trend of increases with lesion development. Violent bubble activities were visible in the gel and were evident as strongly echogenic regions in the differential IBS images and B-mode images simultaneously. This was detected by a dramatic high level of subharmonic and broadband noise at the same time. These bubble activities caused fluctuations in IBS and attenuation coefficient during HIFU treatment. After HIFU, IBS and attenuation coefficient decreased gradually accompanied by the fadeout of bright hyperechoic spot in the B-mode and differential IBS image, but were still higher than normal when they were stable. The increases of IBS and attenuation coefficient were greater when using higher acoustic power or a higher duty cycle of the therapeutic emission. These experiments indicated that the bubble activities had the dominant effects on the transient characteristics of IBS and attenuation. This should be taken into consideration when using the dynamic acoustic-property changes for the potentially real-time monitoring imaging of HIFU treatment.

Feasibility of using Nakagami distribution in evaluating the formation of ultrasound-induced thermal lesions.

The acoustic posterior shadowing effects of bubbles influence the accuracy for defining the location and range of ablated thermal lesions during focused ultrasound surgery when using ultrasonic monitoring imaging. This paper explored the feasibility of using Nakagami distribution to evaluate the ablated region induced by focused ultrasound exposures at different acoustic power levels in transparent tissue-mimicking phantoms. The mean value of the Nakagami parameter m was about 0.5 in the cavitation region and increased to around 1 in the ablated region. Nakagami images were not subject to significant shadowing effects of bubbles. Ultrasound-induced thermal lesions observed in the photos and Nakagami images were overshadowed by bubbles in the B-mode images. The lesion size predicted in the Nakagami images was smaller than that predicted in the photos due to the sub resolvable effect of Nakagami imaging at the interface. This preliminary study on tissue-mimicking phantom suggested that the Nakagami parameter m may have the potential use in evaluating the formation of ultrasound-induced thermal lesion when the shadowing effect of bubbles is strong while the thermal lesion was small. Further studies in vivo and in vitro will be needed to evaluate the potential application.

Enhancement of electrolarynx speech based on auditory masking

Electrolarynx (EL) speech provides a valuable means of verbal communication for the laryngectomees. Yet EL speech tends to be less intelligible speech due to the presence of background noise. This paper addresses the issue of EL speech enhancement. The proposed approach takes into account the frequency-domain masking properties of the human auditory system for a subtractive-type enhancement process. Subtractive-type algorithms can efficiently reduce the radiated noise of EL speech but not to reduce the additive noise from the environment due to the use of fixed subtraction parameters. Considering the particular characteristics of EL speech, a new computationally efficient algorithm based on the perceptual weighting technique is developed to adapt the subtraction parameters. This leads to a significant reduction of the unnatural structure of the residual noise. Acoustic and perceptual experiments confirm that the enhanced EL speech is more pleasant to human listeners and the proposed algorithm results in improved performance over classical subtractive-type algorithms

Improving Reliability and Accuracy of Vibration Parameters of Vocal Folds Based on High-Speed Video and Electroglottography

Quantified vibration parameters of vocal folds, including parameters directly extracted from high-speed video (HSV) and electroglottography (EGG), and inverse parameters based on models, can accurately describe the mechanism of phonation and also classify the abnormal in clinics. In order to improve the reliability and accuracy of these parameters, this paper provides a method based on an integrated recording system. This system includes two parts: HSV and EGG, which can record vibration information of vocal folds simultaneously. An image processing approach that bases on Zernike moments operator and an improved level set algorithm is proposed to detect glottal edges at subpixel-level aiming at image series recorded by HSV. An approach is also introduced for EGG data to extract three kinds of characteristic points for special vibration instants. Finally, inverse parameters of vocal folds can be optimized by a genetic algorithm based on the experimental vibration behaviors synthesized with these parameters and the simulations of a two-mass model. The results of a normal phonation experiment indicate that the parameters extracted by this method are more accurate and reliable than those extracted by general methods, which were only on the basis of HSV data and with pixel-level processing approaches in former studies.

Numerical study of the effects of inferior and superior vocal fold surface angles on vocal fold pressure distributions

Vocal fold geometry plays an important role in human phonation. A wide range of inferior and superior vocal fold surface angles has been shown to be present during phonation [Nanayakkara, Masters thesis, Bowling Green State University, Bowling Green, OH (2005)]. This study explored how these angles affect pressure distributions on the vocal folds, and thus how they may affect phonation. The computational code FLUENT was used to obtain pressure distributions for laminar, incompressible flow. Eighteen inferior vocal fold surface angles and nineteen superior vocal fold surface angles were selected for three specific glottal angles, uniform 0 degrees, convergent 10 degrees, and divergent 10 degrees. Minimal glottal diameter (0.01 cm), transglottal pressure (8 cm H2O), and glottal entrance radius (0.15 cm) were held constant, and the glottal exit radius was constant for each glottal angle. Results suggest that the vocal fold surface pressures are independent of the inferior and superior vocal fold surface angles realistic for human phonation. These results suggest that, in contrast to the important effects of glottal entrance and exit radii, minimal diameter, and angle on intraglottal pressures, the inferior and superior vocal fold surface angles (excluding possible interactive effects with the false vocal folds) do not have an influence on the intraglottal pressures.

The effect of glottal angle on intraglottal pressure.

Intraglottal pressure distributions depend upon glottal shape, size, and diameter. This study reports the effects of varying glottal angle on intraglottal and transglottal pressures using a three-dimensional Plexiglas model with a glottis having nine symmetric glottal angles and a constant minimal glottal diameter of 0.06 cm. The empirical data were supported by computational results using FLUENT. The results suggested that (1) the greater the convergent glottal angle, the greater outward driving forces (higher intraglottal pressures) on the vocal folds; (2) flow resistance was greatest for the uniform glottis, and least for the 10 degrees divergent glottis; (3) the greatest negative pressure in the glottis and therefore the greatest pressure recovery for diverging glottal shapes occurred for an angle of 10 degrees; (4) the smaller the convergent angle, the greater the flow resistance; (5) FLUENT was highly accurate in predicting the empirical pressures of this model; (6) flow separation locations (given by FLUENT) for the divergent glottis moved upstream for larger flows and larger glottal angles. The results suggest that phonatory efficiency related to aerodynamics may be enhanced with vocal fold oscillations that include large convergent angles during glottal opening and small (5 degrees - 10 degrees) divergent angles during glottal closing.

Enhanced Lesion-to-Bubble Ratio on Ultrasonic Nakagami Imaging for Monitoring of High-Intensity Focused Ultrasound

This work explored the feasibility of using ultrasonic Nakagami imaging to enhance the contrast between thermal lesions and bubbles induced by high‐intensity focused ultrasound (US) in a transparent tissue‐mimicking phantom at different acoustic power levels.

Effects of Place of Articulation and Aspiration on Voice Onset Time in Mandarin Esophageal Speech

The ability of Mandarin esophageal speakers to distinguish between aspirated and unaspirated stops, and to distinguish between different places of articulation of stops were examined. Aspirated and unaspirated voiceless stops produced by normal laryngeal (NL) and standard esophageal (SE) speakers were studied. VOT values of the five different stops (/ph, th, kh, p, t/) of Mandarin followed by the vowel /a/ produced by NL and SE speakers were compared. Results from the perceptual experiment indicated that, while voiceless unaspirated stops produced by SE speakers were not signaled with a high level of accuracy, voiceless aspirated stops were perceived correctly by the listeners. Acoustic analysis showed that SE speakers consistently produced shorter VOT than NL speakers. Velar stops were associated with significantly longer VOT values than bilabial and alveolar stops in NL speakers. It was also found that, with the use of the PE segment, SE speakers were still able to use VOT to distinguish between aspirated and unaspirated stops, but they were unable to distinguish between bilabial, alveolar, and velar places of articulation.

A fast tissue stiffness-dependent elastography for HIFU-induced lesions inspection

To monitor HIFU-induced lesion with elastography in quasi-real time, a fast correlation based elastographic algorithm using tissue stiffness-dependent displacement estimation (SdDE) is developed in this paper. The high time efficiency of the proposed method contributes to the reduction on both the number of the displacement points and the computational time of most of the points by utilizing local uniformity of the tissue under HIFU treatment. To obtain admirable comprehensive performance, the key algorithm parameter, a threshold to densify the displacement points, is optimized with simulation over a wedge-inclusion tissue model by compromising the axial resolution (AR) and the computational cost. With the optimum parameter, results from both simulations and phantom experiments show that the SdDE is faster in about one order of magnitude than the traditional correlation based algorithm. At the same time, other performance parameters, such as the signal-to-noise ratio (SNRe), the contrast-to-noise ratio (CNRe) and the axial resolution (AR), are superior to or comparable with that obtained from the traditional algorithm. In vitro experiments on bovine livers validate the improvement on the time efficiency under the circumstances of real tissue and real radio frequency (RF) signal. This preliminary work implies potential of the SdDE in dynamic or close real time guidance and monitoring of HIFU treatment.

Minimizing the thermal losses from perfusion during focused ultrasound exposures with flowing microbubbles

This paper demonstrated the use of flowing microbubbles (MBs) to minimize thermal losses from perfusion during focused ultrasound exposures due to acoustic cavitation. Temperature and cavitation were simultaneously investigated as MBs flowing through a wall-less flow phantom with varying flow velocities (2-55 cm/s) and concentrations (0%-0.1%) when exposed at different acoustic power levels (5-120 W). The peak temperature at the end of ultrasonic exposures in the flow and in the outer of the vessel as well as the cavitation were higher than those pure controls measured at the same exposure parameters and flow velocities but without MBs. All the peak temperatures initially increased with increasing flow velocities of MBs, followed by a decrease of the peak temperatures with increasing flow velocities when the velocity was higher than the inflection velocity. Meanwhile, cavitation showed a trend of increases with increasing flow velocity. The inflection velocity and cavitation increased with increasing acoustic power and MBs concentration. Thermal lesion appeared around the vessel as MBs flow through the vessel, at which lesion was not observed originally without MBs. These results suggested that this may provide an effective way to minimize thermal losses from perfusion during focused ultrasound exposures.