Susan L. Henke

Asymmetric synthesis of highly functionalized polyazamacrocycles via reduction of cyclic peptide precursors

Abstract A general synthetic method for the preparation of carbon-functionalized polyazamacrocycles from the corresponding cyclic peptides is described.

Superoxide dismutase mimics as future therapeutics

Superoxide dismutase (SOD) enzymes are ubiquitous in living things. These enzymes serve a vital role in defending oxygen-utilising life forms from oxidative damage. As a commercial human therapeutic, the enzyme SOD has been used to treat arthritis, inflammation and the side-effects of radiation treatment. Superoxide dismutase mimics (SODm) have been developed for the treatment of many diseases which involve an excess of superoxide. In this review, the advantages of using an SODm will be addressed as well as methods for measuring SOD activity. The SODm in current patent literature including manganese salen complexes, manganese porphyrin complexes, manganese pentaaza macrocyclic complexes, copper complexes, and nitroxides, will be compared based on available physical and biological data. The activity of these mimics has been measured directly or indirectly to determine catalytic rates and in efficacy studies ranging from cell cultures to animal studies. SODm have been investigated in animal models for a var...

New conformationally constrained polyaza macrocycles prepared via the bis(chloroacetamide) method

Abstract The synthesis of two new series of conformationally constrained polyazamacrocycles featuring polysubstitution at macrocycle ring carbons is described.