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Dive into the research topics where Susanne Schubert-Bast is active.

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Featured researches published by Susanne Schubert-Bast.


Epilepsia | 2015

Long‐term seizure outcome in 211 patients with focal cortical dysplasia

Susanne Fauser; Charles Essang; Dirk-Matthias Altenmüller; Anke M. Staack; Bernhard J. Steinhoff; Karl Strobl; Thomas Bast; Susanne Schubert-Bast; Ulrich Stephani; Gert Wiegand; Marco Prinz; Armin Brandt; Josef Zentner; Andreas Schulze-Bonhage

Focal cortical dysplasia (FCD) is currently recognized as the most common cause of neocortical pharmacoresistant epilepsy. Epilepsy surgery has become an increasingly successful treatment option. Herein, the largest patient cohort reported to date is analyzed regarding long‐term outcome and factors relevant for long‐term seizure control.


Epilepsia | 2013

Rasmussen encephalitis: Incidence and course under randomized therapy with tacrolimus or intravenous immunoglobulins

Christian G. Bien; Henning Tiemeier; Robert Sassen; Stefan Kuczaty; Horst Urbach; Marec von Lehe; Albert J. Becker; Thomas Bast; Peter Herkenrath; Michael Karenfort; Bernd Kruse; G. Kurlemann; Sabine Rona; Susanne Schubert-Bast; Silvia Vieker; S Vlaho; Bernd Wilken; Christian E. Elger

Purpose:  Rasmussen encephalitis (RE) leads to progressive tissue and function loss of one brain hemisphere and often intractable epilepsy. This is the first randomized prospective treatment trial in RE.


European Journal of Paediatric Neurology | 2013

Seizure and cognitive outcomes of epilepsy surgery in infancy and early childhood

Georgia Ramantani; Navah Ester Kadish; Karl Strobl; Armin Brandt; Angeliki Stathi; Hans Mayer; Susanne Schubert-Bast; Gert Wiegand; Rudolf Korinthenberg; Ulrich Stephani; Vera van Velthoven; Josef Zentner; Andreas Schulze-Bonhage; Thomas Bast

AIMS To investigate seizure and developmental outcomes following epilepsy surgery in very young children and determine their predictive factors. METHODS We retrospectively reviewed the clinical data, surgical variables, and outcomes of 30 children under 3 years of age that underwent resection for refractory focal epilepsy in our institution in 2001-2011. RESULTS Seizure onset was in the first year of life in 27 (90%) cases and mean age at surgery was 20 months (range 5-33.6). Pathology consisted of cortical malformations in 24 (80%) cases, glioneuronal tumour and infarction with or without cortical dysplasia in three (10%) cases each. Morbidity was comparable with older paediatric cohorts. At 1-11.6 year follow-up (mean 4.1) 21 of 30 (70%) children achieved seizure freedom (Engel I), six (20%) demonstrated worthwhile improvement (Engel II/III) and three (10%) did not benefit from surgery (Engel IV). Intralobar lesionectomy more often resulted in seizure freedom than multilobar or hemispheric surgery. The abundance of non-regional interictal and ictal EEG findings did not preclude seizure freedom. Presurgical developmental impairment was established in 25 of 28 (89%) children; its severity correlated with longer epilepsy duration and determined postoperative developmental outcome. Developmental progress was established in 26 out of 28 (93%) children following surgery, showing stabilized trajectories rather than catch-up. CONCLUSIONS Resective surgery in very young children is safe and effective in terms of seizure control and developmental progress. Our findings underline the importance of early intervention in order to timely stop seizures and their deleterious effects on the developing brain.


Epilepsia | 2013

Seizure control and developmental trajectories after hemispherotomy for refractory epilepsy in childhood and adolescence

Georgia Ramantani; Navah Ester Kadish; Armin Brandt; Karl Strobl; Angeliki Stathi; Gert Wiegand; Susanne Schubert-Bast; Hans Mayer; Kathrin Wagner; Rudolf Korinthenberg; Ulrich Stephani; Vera van Velthoven; Josef Zentner; Andreas Schulze-Bonhage; Thomas Bast

To evaluate the seizure control and developmental outcomes after hemispherotomy for refractory epilepsy in childhood and to identify their predictive factors.


Annals of Neurology | 2015

Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery.

Kim Boshuisen; Monique M.J. van Schooneveld; Cuno S.P.M. Uiterwaal; J. Helen Cross; Sue Harrison; Tilman Polster; Marion Daehn; Sarina Djimjadi; Dilek Yalnızoğlu; Guzide Turanli; Robert Sassen; Christian Hoppe; Stefan Kuczaty; Carmen Barba; Philippe Kahane; Susanne Schubert-Bast; Gitta Reuner; Thomas Bast; Karl Strobl; Hans Mayer; Anne de Saint-Martin; Caroline Seegmuller; Agathe Laurent; Alexis Arzimanoglou; Kees P. J. Braun

Antiepileptic drugs (AEDs) have cognitive side effects that, particularly in children, may affect intellectual functioning. With the TimeToStop (TTS) study, we showed that timing of AED withdrawal does not majorly influence long‐term seizure outcomes. We now aimed to evaluate the effect of AED withdrawal on postoperative intelligence quotient (IQ), and change in IQ (delta IQ) following pediatric epilepsy surgery.


Neurosurgery | 2013

Reoperation for refractory epilepsy in childhood: a second chance for selected patients.

Georgia Ramantani; Karl Strobl; Angeliki Stathi; Armin Brandt; Susanne Schubert-Bast; Gert Wiegand; Rudolf Korinthenberg; Ulrich Stephani; Vera van Velthoven; Josef Zentner; Andreas Schulze-Bonhage; Thomas Bast

BACKGROUND Reoperations account for >10% in pediatric epilepsy surgery cohorts, and they are especially relevant in young children with catastrophic epilepsy. OBJECTIVE To determine surgical outcomes and their predictive factors in reoperations for refractory epilepsy in childhood. METHODS We retrospectively analyzed presurgical findings, resections, and outcomes of 23 consecutive children who underwent reoperations from 2000 to 2011. RESULTS Etiology included cortical dysplasia with/without glioneuronal tumor in 19 patients (83%), sole glioneuronal tumor in 2, and tuberous sclerosis and Rasmussen encephalitis in 1 each. The reasons for the failure of the initial surgery were functional considerations in 8 (35%), incorrect delineation of the epileptogenic zone in 8 (35%), and resection not performed as initially planned in 7 (30%) cases. Final procedures included 8 (35%) intralobar, 8 (35%) multilobar resections, and 7 (30%) hemispherotomies. Following reoperations, 14 (61%) patients were seizure free, 6 (26%) showed significant or worthwhile improvement, and 3 (13%) did not respond to surgery. Six of 8 patients who underwent the first resection before the age of 3 years, 6 of 8 whose first resection was limited by functional considerations, and all 7 with hemispherotomy as the final resection achieved seizure freedom after reoperation. CONCLUSION Reoperation is particularly beneficial for selected children with refractory epilepsy associated with cortical dysplasia that did not respond to an initial limited and/or early resection but achieved seizure freedom after extensive procedures. When indicated, reoperation should be performed at the youngest possible age to profit from higher functional plasticity in compensating for neurological deficit.


Neurology | 2016

Phenotypic spectrum of GABRA1 From generalized epilepsies to severe epileptic encephalopathies

Katrine Johannesen; Carla Marini; Siona Pfeffer; R. S. Moller; Thomas Dorn; Cristina Elena Niturad; Elena Gardella; Yvonne G. Weber; Marianne Søndergård; Helle Hjalgrim; Mariana Nikanorova; Felicitas Becker; Line H.G. Larsen; Hans Atli Dahl; Oliver Maier; Davide Mei; Saskia Biskup; Karl Martin Klein; Philipp S. Reif; Felix Rosenow; Abdallah F. Elias; Cindy Hudson; Katherine L. Helbig; Susanne Schubert-Bast; Maria R. Scordo; Dana Craiu; Tania Djémié; Dorota Hoffman-Zacharska; Hande Caglayan; Ingo Helbig

Objective: To delineate phenotypic heterogeneity, we describe the clinical features of a cohort of patients with GABRA1 gene mutations. Methods: Patients with GABRA1 mutations were ascertained through an international collaboration. Clinical, EEG, and genetic data were collected. Functional analysis of 4 selected mutations was performed using the Xenopus laevis oocyte expression system. Results: The study included 16 novel probands and 3 additional family members with a disease-causing mutation in the GABRA1 gene. The phenotypic spectrum varied from unspecified epilepsy (1), juvenile myoclonic epilepsy (2), photosensitive idiopathic generalized epilepsy (1), and generalized epilepsy with febrile seizures plus (1) to severe epileptic encephalopathies (11). In the epileptic encephalopathy group, the patients had seizures beginning between the first day of life and 15 months, with a mean of 7 months. Predominant seizure types in all patients were tonic-clonic in 9 participants (56%) and myoclonic seizures in 5 (31%). EEG showed a generalized photoparoxysmal response in 6 patients (37%). Four selected mutations studied functionally revealed a loss of function, without a clear genotype–phenotype correlation. Conclusions: GABRA1 mutations make a significant contribution to the genetic etiology of both benign and severe epilepsy syndromes. Myoclonic and tonic-clonic seizures with pathologic response to photic stimulation are common and shared features in both mild and severe phenotypes.


Epilepsia | 2017

Postmarketing experience with brivaracetam in the treatment of epilepsies: A multicenter cohort study from Germany

Isabel Steinig; Felix von Podewils; Gabriel Möddel; Sebastian Bauer; Karl Martin Klein; Esther Paule; Philipp S. Reif; Laurent M. Willems; Johann Philipp Zöllner; Rhina Kunz; Uwe Runge; Gerhard Kurlemann; Susanne Schubert-Bast; Felix Rosenow; Adam Strzelczyk

To evaluate factors predicting efficacy, retention, and tolerability of add‐on brivaracetam (BRV) in clinical practice.


Epilepsia | 2017

Lacosamide in status epilepticus: Systematic review of current evidence

Adam Strzelczyk; Johann Philipp Zöllner; Laurent M. Willems; Julie Jost; Esther Paule; Susanne Schubert-Bast; Felix Rosenow; Sebastian Bauer

The intravenous formulation of lacosamide (LCM) and its good overall tolerability and safety favor the use in status epilepticus (SE). The aim of this systematic review was to identify and evaluate studies reporting on the use of LCM in SE.


Epilepsia | 2013

Is there evidence for clinical differences related to the new classification of temporal lobe cortical dysplasia

Susanne Fauser; Charles Essang; Dirk Altenmüller; Anke M. Staack; Bernhard J. Steinhoff; Karl Strobl; Thomas Bast; Susanne Schubert-Bast; Soroush Doostkam; Josef Zentner; Andreas Schulze-Bonhage

The new International League Against Epilepsy (ILAE) classification for focal cortical dysplasia (FCD) differentiates between patients with isolated FCD (type 1) and FCD with an associated hippocampal sclerosis (HS) (type 3a). In contrast to the former FCD classification by Palmini, which considered only histologic features, the novel ILAE classification also relies on magnetic resonance imaging (MRI) findings and presumed pathogenesis. We investigated in a cohort of 100 patients with exclusively temporal FCD if the new subdivision of FCD is reflected in clinical characteristics.

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Adam Strzelczyk

Goethe University Frankfurt

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Felix Rosenow

Goethe University Frankfurt

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Thomas Bast

University of Freiburg

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Karl Martin Klein

Goethe University Frankfurt

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Laurent M. Willems

Goethe University Frankfurt

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