Susanta K. Nayak

Synthesis, polymorphism, and insecticidal activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate against Anopheles arabiensis mosquito.

Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector‐borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1‐b]quinazoline derivative DHPM3 has been synthesized by three‐step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.

Chapter 3:Role of Fluorine in Weak Interactions in Co-crystals

The presence of the C–F bond (commonly referred to as organic fluorine) in a large number of pharmaceutically relevant compounds suggests that it may be used in the production of novel salts and co-crystals that have intermolecular interactions involving fluorine. There is an ongoing debate in this context as fluorine is characterized by its high electronegativity, relatively small size and very low polarizability. The propensity of hydrogen to participate in generating highly directional and energetically stable hydrogen bonds has been exploited in the design of co-crystals and salts of many pharmaceutical compounds. A direct extension of this property to fluorine, however, is not plausible and thus intermolecular interactions involving fluorine must be quantified. Recent results and new approaches designed to evaluate organic fluorine which provide useful inputs for the design of co-crystals and salts are discussed in this chapter.

Quantitative investigation of intermolecular interactions in dimorphs of 3-Chloro-N-(2-fluorophenyl)benzamide and 2-Iodo-N-(4- bromophenyl)benzamide

In this study, we have analyzed the role of different intermolecular interactions in the polymorphic modifications of 3-chloro-N-(2-fluorophenyl)benzamide (I) and 2-iodo-N-(4- bromophenyl)benzamide (II). The crystals were obtained via slow evaporation method with the alteration of solvents for crystallization. The already reported form [Cryst. Growth Des. (2011) 11:1578] crystallizes in P2

Larvicidal study of tetrahydropyrimidine scaffolds against Anopheles arabiensis and structural insight by single crystal X-ray studies

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Structural analysis of 2-iodo­benzamide and 2-iodo-N-phenyl­benzamide

1/c with Z

International Union of Crystallography

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