Sushila Khanna

Desmoid tumors: experience of 32 cases and review of the literature.

BACKGROUND Desmoids are infiltrative, locally destructive, soft tissue tumors. Although they do not metastasize, the incidence of local recurrence is quite high. AIM Present study aimed at reporting the 10-year experience of 32 desmoid cases and reviewing some facts with symptoms, investigation, and treatment of the disease. MATERIALS AND METHODS Thirty two cases of desmoid tumors were reviewed over a 10-year span. Surgical resection and adjuvant radiotherapy were the treatments of choice whenever histological margins were positive. RESULTS Multiparous women in reproductive age were the most commonly afflicted. The commonest site of presentation was the abdominal wall. Ninety one percent (20/22) were infraumbilical. The tumors were found in the rectus sheath in 14 patients (64%) and were laterally situated in 8 patients (36%). Local infiltration was found in six patients and the urinary bladder was most commonly involved (3/6). Locally recurrent desmoids were seen in eight patients (25%). CONCLUSIONS In our experience, 25% of the desmoid tumors (8/32) were recurrent and postoperative radiotherapy did not seem to influence the local recurrence rate. The most important predictor for recurrence was tumors of > 5 cm.

Placental morphometric and morphologic alterations in maternal undernutrition

Placentas, mothers, and neonates belonging to different socioeconomic groups were examined for morphometric and gross morphologic changes to assess the effect of maternal undernutrition. The mean maternal caloric intakes for socioeconomic Groups I, II, and IIII + IV are 2,919, 2420, and 1,589 calories per day, respectively, and differences were significant (P less than 0.001). The mean protein intakes were respectively, 76.1, 67.3, and 52.0 Gm. per day for socioeconomic Groups I, II, and III + IV, respectively (p less than 0.001). The birth weight, placental weight, volume, surface area, and number of cotyledon showed significantly decreasing trends (P less then 0.001) with the fall in socioeconomic group and maternal dietary intakes. Placentas of socioeconomic Group I had significantly higher incidence of well-defined cotyledons and central cord attachment. In lower socioeconomic groups and small-for-dates placentas there was significantly higher incidence of hemorrhages. There were no changes in incidences of placental infarcts, calcifications, and degeneration in various socioeconomic groups.

Accessory scrotum: a case report

Abstract Another example is presented of a rare congenital abnormality: an accessory scrotum—its clinical and histological features are described.

Intensive combination chemotherapy for cancer of the oral cavity

Thirty advanced cases of cancer of the oral cavity were treated by intensive combination chemotherapy using bleomycin, methotrexate, 5‐fluorouracil, cyclophosphamide, and Oncovin administered over a period of 48 hours. Bleomycin was given as a continuous infusion and Oncovin was administered six hours prior to the administration of other drugs. A clinical response was obtained in 73.3% of the cases, a complete response in 33.3%, and a partial response in 40%. The toxicity was within acceptable limits.

Adrenal tumors: An experience of 10 years in a single surgical unit

INTRODUCTION Most of the adrenal masses are discovered incidentally by imaging techniques for reasons unrelated to adrenal diseases. Treatment is based on various factors such as, nature of adrenal mass, age of presentation, size of tumor, and the functional status of tumor. We report a series of 14 consecutive cases of adrenal tumors treated in a single surgical unit in our hospital. AIM The aim of this study was to evaluate the clinical profile and outcome of treatment of adrenal tumors treated in a surgical unit. MATERIALS AND METHODS It is a retrospective study data of 14 cases of adrenal tumors treated in a single surgical unit in University Hospital over 10 years have been analyzed. Various parameters such as gender, age, size of tumor, functional status, histopathology, type of management, and outcome have been reviewed. RESULTS A total of 14 patients with adrenal masses were seen over a 10 year period (1997-2006). All were referred cases, either from endocrinology or medicine wards. There were seven female and seven male patients. Mean age of patients was 48.6 years (range 14-60 years). Mean size of tumor was 8.0 cm (5.9 cm for benign tumors and 9.7 cm for malignant tumors). There were six cases of adrenal carcinoma, four cases of adrenal myelolipoma, two cases of pheochromocytoma, and one each case of adrenal hyperplasia and histoplasmosis. There were only two functional tumors. All, except two malignant cases were treated operatively. A total of 5 year survival was 100% in benign cases and 27% in malignant tumors. CONCLUSION Adrenal tumors need to be assessed for their functional status and malignant potential prior to treatment. Surgical excision is usually curative for benign lesion. Among malignant tumors the benefits of surgery depend on local extent and metastatic status of tumors.

Neurilemmoma of the parapharyngeal space

Neurilemmomas are rare neurogenic tumours and their parapharyngeal location is very uncommon, A case of neurilemmoma of this location is presented.

Cytohormonal Assessment of Ovarian Function Following Tubal Ligation

One hundred fifty postligation and 54 random cases matched for age and parity were studied. Vaginal cytologic samples and endometrial histologic samples were used for cytohormonal assessment of ovarian function. There was no indication of ovarian insufficiency following tubal ligation. The menstrual cycles were ovulatory. Menstrual disturbances were seen in 40.6% of the cases following tubal ligation. Cytohormonal comparison of these cases with that of dysfunctional uterine bleeding cases (who did not undergo tubal ligation) showed either similar or high maturation value. This may be due either to psychological stimulation or to low‐grade infection following tubal ligation. There was complete cytomorphologic correlation.

Fibrous dysplasia of the mastoid

A rare case of fibrous dysplasia involving the mastoid bone is reported. Its histopathological characteristics are also described.