Suzanne C. Segerstrom

Psychological Stress and the Human Immune System: A Meta-Analytic Study of 30 Years of Inquiry

The present report meta-analyzes more than 300 empirical articles describing a relationship between psychological stress and parameters of the immune system in human participants. Acute stressors (lasting minutes) were associated with potentially adaptive upregulation of some parameters of natural immunity and downregulation of some functions of specific immunity. Brief naturalistic stressors (such as exams) tended to suppress cellular immunity while preserving humoral immunity. Chronic stressors were associated with suppression of both cellular and humoral measures. Effects of event sequences varied according to the kind of event (trauma vs. loss). Subjective reports of stress generally did not associate with immune change. In some cases, physical vulnerability as a function of age or disease also increased vulnerability to immune change during stressors.

Dispositional Optimism and Coping: A Meta-Analytic Review

The relation between dispositional optimism and better adjustment to diverse stressors may be attributable to optimisms effects on coping strategies. A meta-analytic review (K = 50, N = 11,629) examined the impact of dispositional optimism on coping. Dispositional optimism was found to be positively associated with approach coping strategies aiming to eliminate, reduce, or manage stressors or emotions (r = .17), and negatively associated with avoidance coping strategies seeking to ignore, avoid, or withdraw from stressors or emotions (r = -.21). Effect sizes were larger for the distinction between approach and avoidance coping strategies than for that between problem and emotion-focused coping. Meta-analytic findings also indicate that optimists may adjust their coping strategies to meet the demands of the stressors at hand, and that the optimism-coping relationship is strongest in English-speaking samples.

Optimism is associated with mood, coping, and immune change in response to stress.

This study explored prospectively the effects of dispositional and situational optimism on mood (N = 90) and immune changes (N = 50) among law students in their first semester of study. Optimism was associated with better mood, higher numbers of helper T cells, and higher natural killer cell cytotoxicity. Avoidance coping partially accounted for the relationship between optimism and mood. Among the immune parameters, mood partially accounted for the optimism-helper T cell relationship, and perceived stress partially accounted for the optimism-cytotoxicity relationship. Individual differences in expectancies, appraisal, and mood may be important in understanding psychological and immune responses to stress.

Worry and Rumination: Repetitive Thought as a Concomitant and Predictor of Negative Mood

Worry and depressive rumination have both been described as unproductive, repetitive thought which contributes to anxiety or depression, respectively. It was hypothesized that repetitive thought, rather than its specific forms, is a general concomitant of negative mood. Study 1 was a cross-sectional test of the hypothesis. Repetitive thought was positively correlated with anxiety and depression in students (n = 110). In patients (n = 40), repetitive thought was positively correlated with anxiety and depression, and rumination was also specifically correlated with depression. Study 2 was a prospective test of the hypothesis. In students (n = 90), there were significant cross-sectional relationships between repetitive thought and both anxiety and depression. In addition, repetitive thought at least partially predicted maintenance of anxious symptoms. Phenomena such as goal interruption, failures of emotional processing, and information processing may lead to repetitive thought which increases negative mood states, including both anxiety and depression.

Heart Rate Variability Reflects Self-Regulatory Strength, Effort, and Fatigue

Experimental research reliably demonstrates that self-regulatory deficits are a consequence of prior self-regulatory effort. However, in naturalistic settings, although people know that they are sometimes vulnerable to saying, eating, or doing the wrong thing, they cannot accurately gauge their capacity to self-regulate at any given time. Because self-regulation and autonomic regulation colocalize in the brain, an autonomic measure, heart rate variability (HRV), could provide an index of self-regulatory strength and activity. During an experimental manipulation of self-regulation (eating carrots or cookies), HRV was elevated during high self-regulatory effort (eat carrots, resist cookies) compared with low self-regulatory effort (eat cookies, resist carrots). The experimental manipulation and higher HRV at baseline independently predicted persistence at a subsequent anagram task. HRV appears to index self-regulatory strength and effort, making it possible to study these phenomena in the field as well as the lab.

A Multidimensional Structure for Repetitive Thought: What's on Your Mind, and How, and How Much?

Although repetitive thought (RT) styles such as worry, rumination, and processing correlate positively, they have divergent effects on well-being, suggesting important dimensional variation. In Study 1, multidimensional scaling identified 2 dimensions--positive versus negative content valence and searching versus solving purpose--among students (N=978) who completed standard RT measures. In Study 2, students (N=100) sorted 25 descriptions of RT. Multidimensional scaling identified 4 dimensions, including valence and purpose. Content valence associated with valenced affect; solving associated with less aroused affect and less polarized appraisals of thought topics. In Study 3, valence and purpose of RT descriptions by women in a breast cancer prevention trial (N=62) predicted concurrent affect and psychological and physical well-being.

Optimism and Attentional Bias for Negative and Positive Stimuli

Optimism, or positive outcome expectancy, correlates with better psychological and physiological adjustment, in part because of conscious behavior such as coping. However, procedural, automatic, and unconscious processes also may affect adjustment. The emotional Stroop task was used to assess the relationships between optimism and unconscious attentional bias for positively valenced, negatively valenced, neutral current concern, and neutral control stimuli. Undergraduate students (n = 48) completed personality measures at the beginning of the semester and completed the Stroop task under separate cover. Optimism was associated with a greater attentional bias for positive stimuli relative to negative stimuli. Optimism also was associated with slower skin conductance response rates during negative stimuli. Unconscious attentional biases may contribute to the better adjustment associated with optimism.

Posttraumatic growth and PTSD symptomatology among colorectal cancer survivors: a 3‐month longitudinal examination of cognitive processing

Introduction: The experience of cancer can be understood as a psychosocial transition, producing both positive and negative outcomes. Cognitive processing may facilitate psychological adjustment.

Executive Functions, Self-Regulation, and Chronic Pain: A Review

BackgroundChronic pain conditions are complicated and challenging to live with. Capacity to adjust to such conditions may depend on the ability to self-regulate, that is, the ability to alter thoughts, feelings, and behaviors. Self-regulation appears to rely on executive cognitive functions, and the current review, therefore, sought to draw attention to the impact of self-regulatory capacity and executive functions on chronic pain.DiscussionChronic pain conditions present with complex interactions of cognitive, emotional, behavioral, and physiological components for which self-regulatory ability is crucial. The ability to self-regulate varies, and self-regulatory strength appears to be a limited resource that can be fatigued. The many challenges of chronic pain conditions could, therefore, tax self-regulatory strength, leading to self-regulatory deficits.ConclusionThe current review proposes a relationship among pain, self-regulatory capacity, self-regulatory demands, executive functions, and self-regulatory fatigue, suggesting that executive functions and self-regulatory deficits are indeed part of the etiology and maintenance of chronic pain conditions.

Engagement and Arousal: Optimism’s Effects During a Brief Stressor

Optimism is usually associated with better psychological and physiological adjustment to stressors, but some contradictory findings exist. The purpose of this study was to investigate how optimism could result in negative immunological changes following difficult stressors. Because optimists are likely to see positive outcomes as attainable, they may invest greater effort to achieve their goals. It is proposed that such engagement would be more physiologically demanding when pursuing difficult goals. Participants (N = 54) worked on 11 difficult or insoluble anagrams. Optimism when combined with high self-awareness increased time spent working on the anagrams and skin conductance and salivary cortisol during the recovery period. The results support the notion that the increased engagement that arises from optimism may lead to short-term physiological costs.