Suzanne Ross Kesten | Researchain

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Featured researches published by Suzanne Ross Kesten.

Bioorganic & Medicinal Chemistry Letters | 2009

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH)

Douglas S. Johnson; Kay Ahn; Suzanne Ross Kesten; Scott E. Lazerwith; Yuntao Song; Mark Morris; Lorraine Kathleen Fay; Tracy Fay Gregory; Cory Michael Stiff; James B. Dunbar; Marya Liimatta; David Beidler; Sarah E. Smith; Tyzoon K. Nomanbhoy; Benjamin F. Cravatt

The synthesis and structure-activity relationships (SAR) of a series of benzothiophene piperazine and piperidine urea FAAH inhibitors is described. These compounds inhibit FAAH by covalently modifying the enzymes active site serine nucleophile. Activity-based protein profiling (ABPP) revealed that these urea inhibitors were completely selective for FAAH relative to other mammalian serine hydrolases. Several compounds showed in vivo activity in a rat complete Freunds adjuvant (CFA) model of inflammatory pain.

ACS Medicinal Chemistry Letters | 2011

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor.

Douglas S. Johnson; Cory Michael Stiff; Scott E. Lazerwith; Suzanne Ross Kesten; Lorraine Kathleen Fay; Mark Morris; David Beidler; Marya Liimatta; Sarah E. Smith; David T. Dudley; Nalini Sadagopan; Shobha N. Bhattachar; Stephen J. Kesten; Tyzoon K. Nomanbhoy; Benjamin F. Cravatt; Kay Ahn

Journal of Medicinal Chemistry | 1999

Design, Synthesis, and Evaluation of Chromen-2-ones as Potent and Selective Human Dopamine D4 Antagonists

Suzanne Ross Kesten; Thomas G. Heffner; Stephen J. Johnson; Thomas A. Pugsley; Jonathan Wright; Lawrence D. Wise

Archive | 1999

4-Benzyl piperidine alkylsulfoxide heterocycles and their use as subtype-selective NMDA receptor antagonists

Jonathan Wright; Suzanne Ross Kesten; Ravindra B. Upasani; Nancy C. Lan

Journal of Medicinal Chemistry | 1992

2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents

David B. Capps; James B. Dunbar; Suzanne Ross Kesten; Joan L. Shillis; Leslie M. Werbel; Jacqueline Plowman; Donald L. Ward

Archive | 2007

Biaryl ether urea compounds

Lorraine Kathleen Fay; Douglas S. Johnson; Suzanne Ross Kesten; Scott E. Lazerwith; Mark Anthony Morris; Cory Michael Stiff; Marvin Jay Meyers; Lijuan Jane Wang

Journal of Medicinal Chemistry | 2000

Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.

Anthony P. Guzikowski; Amir P. Tamiz; Manuel Acosta-Burruel; Soo Hong-Bae; Sui Xiong Cai; Jon E. Hawkinson; John F. W. Keana; Suzanne Ross Kesten; Christina T. Shipp; Minhtam Tran; Edward R. Whittemore; Richard M. Woodward; Jon Wright; Zhang-Lin Zhou

Journal of Medicinal Chemistry | 1998

Aminopyrimidines with High Affinity for Both Serotonin and Dopamine Receptors

David Juergen Wustrow; Thomas Richard Belliotti; Shelly Ann Glase; Suzanne Ross Kesten; Don Johnson; Norman L. Colbry; Ronald Rubin; Anthony C. Blackburn; Hyacinth Akunne; Ann E. Corbin; M. Duff Davis; Lynn M. Georgic; Steven Z. Whetzel; Kim Zoski; Thomas G. Heffner; Thomas A. Pugsley; Lawrence D. Wise

Archive | 1994

Naphthalamides as central nervous system agents

Shelly Ann Glase; Suzanne Ross Kesten; Lawrence D. Wise; Jonathan Wright

Journal of Medicinal Chemistry | 1994

The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-[(arylcyclohexenyl)alkyl]pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents

Jon Wright; Bradley William Caprathe; Dennis Michael Downing; Shelly Ann Glase; Thomas G. Heffner; Juan C. Jaen; Stephen J. Johnson; Suzanne Ross Kesten; Robert G. MacKenzie

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